The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?
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Date
2017-12-01ICR Author
Author
Mansur, MB
Ford, AM
Emerenciano, M
Type
Journal Article
Metadata
Show full item recordAbstract
Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. Recent investigations have identified co-operating mutations in the RAS pathway and although the functional consequences of these mutations are not yet fully understood, aberrant regulation of RAS pathway signalling at both transcriptional and protein levels is observed. Studies investigating the efficacy of specific inhibitors of this pathway, e.g. MEK-inhibitors, have also achieved encouraging results. In this context, this mini-review summarizes the available data surrounding MLL-r infant ALL with RAS mutation in relation to other well-known features of this intriguing disease.
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Subject
Humans
Histone-Lysine N-Methyltransferase
Mitogen-Activated Protein Kinase Kinases
Gene Rearrangement
Mutation
Genes, ras
Myeloid-Lymphoid Leukemia Protein
fms-Like Tyrosine Kinase 3
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Research team
Biology of Childhood Leukaemia
Language
eng
Date accepted
2017-10-18
License start date
2017-12
Citation
Biochimica et biophysica acta. Reviews on cancer, 2017, 1868 (2), pp. 521 - 526
Publisher
ELSEVIER