Browsing by title
Now showing items 2387-2406 of 3939
-
A N-15 NMR investigation of a series of benzotriazinones and related antitumour heterocycles
(2002-04)A series of 3-substituted 1,2,3-benzotriazin-4-ones, 1 and 2, were synthesized by standard methods and the N-15 NMR spectra were recorded. All spectra were obtained using the natural abundance of the nitrogen-15 isotope. ... -
N-acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation
(LIPPINCOTT WILLIAMS & WILKINS, 2006-06)Background N-Acetyltransferases (NATs) and sulfotransferases (SULTs) are key phase 11 metabolizing enzymes that can be involved both in the detoxification and in the activation of many human promutagens and procarcinogens. ... -
N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast
(LIPPINCOTT WILLIAMS & WILKINS, 2001-07) -
Nanoneedle-Mediated Stimulation of Cell Mechanotransduction Machinery.
(2019-03-04)Biomaterial substrates can be engineered to present topographical signals to cells which, through interactions between the material and active components of the cell membrane, regulate key cellular processes and guide cell ... -
Nanostructures from Synthetic Genetic Polymers.
(2016-06)Nanoscale objects of increasing complexity can be constructed from DNA or RNA. However, the scope of potential applications could be enhanced by expanding beyond the moderate chemical diversity of natural nucleic acids. ... -
A narrow deletion of 7q is common to HCL, and SMZL, but not CLL
(BLACKWELL MUNKSGAARD, 2004-06)To further characterise the genetic background of the two closely related B-lymphocytic malignancies hairy cell leukaemia (HCL), and splenic marginal zone lymphoma (SMZL) we have identified characteristic copy number ... -
The National Cancer Institute Cohort Consortium: An International Pooling Collaboration of 58 Cohorts from 20 Countries.
(2018-11)Cohort studies have been central to the establishment of the known causes of cancer. To dissect cancer etiology in more detail-for instance, for personalized risk prediction and prevention, assessment of risks of subtypes ... -
National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection - recommendations from a UK consensus meeting.
(2018-07)OBJECTIVES:To identify areas of agreement and disagreement in the implementation of multi-parametric magnetic resonance imaging (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS:Fifteen UK experts ... -
The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer.
(2015-12)BACKGROUND:The management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity of rationally selected biomarker/targeted therapy combinations. ... -
Nationwide trends in the incidence and outcome of patients with gastrointestinal stromal tumour in the imatinib era.
(2018-07)BACKGROUND:The incidence, treatment and outcome of patients with newly diagnosed gastrointestinal stromal tumour (GIST) were studied in an era known for advances in diagnosis and treatment. METHODS:Nationwide population-based ... -
Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
(2017-02)Evolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in ... -
NCLs and ER: A stressful relationship
(2017)The Neuronal Ceroid Lipofuscinoses (NCLs, Batten disease) are a group of inherited neurodegenerative disorders with variable age of onset, characterized by the lysosomal accumulation of autofluorescent ceroid lipopigments. ... -
Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin.
(2019-10-15)Bioluminescence imaging (BLI) is ubiquitous in scientific research for the sensitive tracking of biological processes in small animal models. However, due to the attenuation of visible light by tissue, and the limited set ... -
Near-infrared photoimmunotherapy targeting EGFR-Shedding new light on glioblastoma treatment.
(2018-06)Glioblastomas (GBMs) are high-grade brain tumors, differentially driven by alterations (amplification, deletion or missense mutations) in the epidermal growth factor receptor (EGFR), that carry a poor prognosis of just ... -
Needle tract seeding following core biopsies in retroperitoneal sarcoma.
(2017-09)Retroperitoneal tumours often require a preoperative core needle biopsy to establish a histological diagnosis. Literature is scarce regarding the risk of biopsies in retroperitoneal sarcomas, so the aim of this study is ... -
Negative and positive regulation of HIF-1: A complex network
(ELSEVIER SCIENCE BV, 2005-07-25)Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis ... -
Neoadjuvant cisplatin and fluorouracil versus epirubicin, cisplatin, and capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): an open-label, randomised phase 3 trial.
(2017-09)BACKGROUND:Neoadjuvant chemotherapy before surgery improves survival compared with surgery alone for patients with oesophageal cancer. The OE05 trial assessed whether increasing the duration and intensity of neoadjuvant ...
