Browsing ICR Divisions by author "Houlston, Richard"
Now showing items 41-60 of 182
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Exploiting gene dependency to inform drug development for multiple myeloma.
Went, M; Hoang, PH; Law, PJ; Kaiser, MF; Houlston, RS (NATURE PORTFOLIO, 2022-07-26)Despite recent advances in therapy, multiple myeloma essentially remains an incurable malignancy. Targeting tumour-specific essential genes, which constitute a druggable dependency, potentially offers a strategy for ... -
Exploring causality in the association between circulating 25-hydroxyvitamin D and colorectal cancer risk: a large Mendelian randomisation study.
He, Y; Timofeeva, M; Farrington, SM; Vaughan-Shaw, P; Svinti, V; et al. (BMC, 2018-08-14)BACKGROUND: Whilst observational studies establish that lower plasma 25-hydroxyvitamin D (25-OHD) levels are associated with higher risk of colorectal cancer (CRC), establishing causality has proven challenging. Since ... -
Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis.
Li, W; Zhou, X; Yuan, S; Wang, L; Yu, L; et al. (AMER ASSOC CANCER RESEARCH, 2023-06-01)BACKGROUND: Human gut microbiome has complex relationships with the host, contributing to metabolism, immunity, and carcinogenesis. METHODS: Summary-level data for gut microbiota and metabolites were obtained from MiBioGen, ... -
Familial risks of acute myeloid leukemia, myelodysplastic syndromes, and myeloproliferative neoplasms.
Sud, A; Chattopadhyay, S; Thomsen, H; Sundquist, K; Sundquist, J; et al. (AMER SOC HEMATOLOGY, 2018-08-30) -
Five endometrial cancer risk loci identified through genome-wide association analysis.
Cheng, TH; Thompson, DJ; O'Mara, TA; Painter, JN; Glubb, DM; et al. (NATURE PORTFOLIO, 2016-06-01)We conducted a meta-analysis of three endometrial cancer genome-wide association studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and 37,144 controls of European ancestry. Genome-wide imputation ... -
Frequency of pathogenic germline variants in cancer susceptibility genes in 1336 renal cell carcinoma cases.
Yngvadottir, B; Andreou, A; Bassaganyas, L; Larionov, A; Cornish, AJ; et al. (OXFORD UNIV PRESS, 2022-08-25)Renal cell carcinoma (RCC) occurs in a number of cancer predisposition syndromes, but the genetic architecture of susceptibility to RCC is not well defined. We investigated the frequency of pathogenic and likely pathogenic ... -
Functional dissection of inherited non-coding variation influencing multiple myeloma risk.
Ajore, R; Niroula, A; Pertesi, M; Cafaro, C; Thodberg, M; et al. (NATURE PORTFOLIO, 2022-01-10)Thousands of non-coding variants have been associated with increased risk of human diseases, yet the causal variants and their mechanisms-of-action remain obscure. In an integrative study combining massively parallel ... -
Functional variants in DCAF4 associated with lung cancer risk in European populations.
Liu, H; Liu, Z; Wang, Y; Stinchcombe, TE; Owzar, K; et al. (OXFORD UNIV PRESS, 2017-05-01)Cullin-RING ubiquitin ligases (CRLs) responsible for substrate specificity of ubiquitination play a key role in cell-cycle control and DNA damage response. In this study, we assessed associations between 16 599 SNPs in 115 ... -
Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2.
Studd, JB; Vijayakrishnan, J; Yang, M; Migliorini, G; Paulsson, K; et al. (NATURE PORTFOLIO, 2017-03-03)Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. ... -
Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.
Went, M; Sud, A; Speedy, H; Sunter, NJ; Försti, A; et al. (NATURE PUBLISHING GROUP, 2018-12-21)The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma ... -
Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism.
Studd, JB; Yang, M; Li, Z; Vijayakrishnan, J; Lu, Y; et al. (SPRINGERNATURE, 2019-01-01)Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Genome-wide association studies have shown variation at 14q11.2 influences ALL risk. We sought to decipher causal variant(s) at 14q11.2 and the ... -
Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism.
Kandaswamy, R; Sava, GP; Speedy, HE; Beà, S; Martín-Subero, JI; et al. (CELL PRESS, 2016-08-23)Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which ... -
Genetic predisposition to chronic lymphocytic leukemia.
Law, PJ; Houlston, RS (LIPPINCOTT WILLIAMS & WILKINS, 2019-06-01) -
Genetic predisposition to mosaic Y chromosome loss in blood.
Thompson, DJ; Genovese, G; Halvardson, J; Ulirsch, JC; Wright, DJ; et al. (NATURE PORTFOLIO, 2019-11-28)Mosaic loss of chromosome Y (LOY) in circulating white blood cells is the most common form of clonal mosaicism1-5, yet our knowledge of the causes and consequences of this is limited. Here, using a computational approach, ... -
Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism.
Li, N; Johnson, DC; Weinhold, N; Kimber, S; Dobbins, SE; et al. (CELL PRESS, 2017-09-12)Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by ... -
Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.
Feng, Y; Wang, Y; Liu, H; Liu, Z; Mills, C; et al. (NATURE PORTFOLIO, 2017-04-11)The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. ... -
Genetic Variation in ABCC4 and CFTR and Acute Pancreatitis during Treatment of Pediatric Acute Lymphoblastic Leukemia.
Bartram, T; Schütte, P; Möricke, A; Houlston, RS; Ellinghaus, E; et al. (MDPI, 2021-10-20)BACKGROUND: Acute pancreatitis (AP) is a serious, mechanistically not entirely resolved side effect of L-asparaginase-containing treatment for acute lymphoblastic leukemia (ALL). To find new candidate variations for AP, ... -
Genetic variation in ST6GAL1 is a determinant of capecitabine and oxaliplatin induced hand-foot syndrome.
Watts, K; Wills, C; Madi, A; Palles, C; Maughan, TS; et al. (WILEY, 2022-09-15)Cancer patients treated with capecitabine and oxaliplatin (XELOX) often develop hand-foot syndrome (HFS) or palmar-plantar erythrodysesthesia. Genetic variation in ST6GAL1 is a risk factor for type-2 diabetes (T2D), a ... -
Genetically predicted physical activity levels are associated with lower colorectal cancer risk: a Mendelian randomisation study.
Zhang, X; Theodoratou, E; Li, X; Farrington, SM; Law, PJ; et al. (SPRINGERNATURE, 2021-03-30)BACKGROUND: We conducted a Mendelian randomisation (MR) study to investigate whether physical activity (PA) causes a reduction of colorectal cancer risk and to understand the contributions of effects mediated through changes ... -
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5.
Claus, EB; Cornish, AJ; Broderick, P; Schildkraut, JM; Dobbins, SE; et al. (OXFORD UNIV PRESS INC, 2018-10-09)BACKGROUND: Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only ...