Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2.
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Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. Here, we sought to determine how this region influences HD-ALL risk. We impute genotypes across the locus, finding the single nucleotide polymorphism rs7090445 highly associated with HD-ALL (P=1.54 × 10-38), and residing in a predicted enhancer element. We show this region physically interacts with the transcription start site of ARID5B, that alleles of rs7090445 have differential enhancer activity and influence RUNX3 binding. RUNX3 knock-down reduces ARID5B expression and rs7090445 enhancer activity. Individuals carrying the rs7090445-C risk allele also have reduced ARID5B expression. Finally, the rs7090445-C risk allele is preferentially retained in HD-ALL blasts consistent with inherited genetic variation contributing to arrest of normal lymphocyte development, facilitating leukaemic clonal expansion. These data provide evidence for a biological mechanism underlying hereditary risk of HD-ALL at 10q21.2.
Cell Line, Tumor
Chromosomes, Human, Pair 10
Genetic Predisposition to Disease
Sequence Analysis, RNA
Gene Expression Regulation, Leukemic
Polymorphism, Single Nucleotide
Core Binding Factor Alpha 3 Subunit
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Enhancer Elements, Genetic
Genome-Wide Association Study
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Nature communications, 2017, 8 pp. 14616 - ?
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by/4.0
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