Browsing Other ICR Research by author "Neidle, Stephen"
Now showing items 1-3 of 3
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Protein and drug interactions in the minor groove of DNA
Moravek, Z; Neidle, S; Schneider, B (2002-03-01)Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein-DNA and 14 drug-DNA complexes. It was found that only purine N3, pyrimidine O2, guanine N2 and ... -
Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands
Neidle, S (2001-05-01)Stabilisation of TG-and AG-containing antiparrallel DNA triplexes by triplex-binding ligands. We have used DNase I footprinting to examine the interaction of several tripler-binding ligands with antiparallel TG- and AG- ... -
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
Read, M; Harrison, RJ; Romagnoli, B; Tanious, FA; Gowan, SH; et al. (2001-04-24)The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ...