Now showing items 1-3 of 3

    • Magnetic Resonance Spectroscopy (MRS)-Based Methods for Examining Cancer Metabolism in Response to Oncogenic Kinase Drug Treatment. 

      Chung, Y-L (2017-01)
      Magnetic resonance spectroscopy (MRS) is an analytical technique that has been extensively used to examine reprogrammed metabolism and treatment response in cancer cells and solid tumors both in vivo and ex vivo. High-resolution ...
    • VHL-Mediated Regulation of CHCHD4 and Mitochondrial Function. 

      Briston, T; Stephen, JM; Thomas, LW; Esposito, C; Chung, Y-L; Syafruddin, SE; Turmaine, M; Maddalena, LA; Greef, B; Szabadkai, G; Maxwell, PH; Vanharanta, S; Ashcroft, M (2018-01)
      Dysregulated mitochondrial function is associated with the pathology of a wide range of diseases including renal disease and cancer. Thus, investigating regulators of mitochondrial function is of particular interest. ...
    • Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. 

      Bilanges, B; Alliouachene, S; Pearce, W; Morelli, D; Szabadkai, G; Chung, Y-L; Chicanne, G; Valet, C; Hill, JM; Voshol, PJ; Collinson, L; Peddie, C; Ali, K; Ghazaly, E; Rajeeve, V; Trichas, G; Srinivas, S; Chaussade, C; Salamon, RS; Backer, JM; Scudamore, CL; Whitehead, MA; Keaney, EP; Murphy, LO; Semple, RK; Payrastre, B; Tooze, SA; Vanhaesebroeck, B (2017-11-27)
      Vps34 PI3K is thought to be the main producer of phosphatidylinositol-3-monophosphate, a lipid that controls intracellular vesicular trafficking. The organismal impact of systemic inhibition of Vps34 kinase activity is not ...