Browsing Other ICR Research by author "Choudhary, Jyoti"
Now showing items 21-31 of 31
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Phosphorylation-Dependent Assembly of a 14-3-3 Mediated Signaling Complex during Red Blood Cell Invasion by Plasmodium falciparum Merozoites.
More, KR; Kaur, I; Giai Gianetto, Q; Invergo, BM; Chaze, T; et al. (AMER SOC MICROBIOLOGY, 2020-08-18)Red blood cell (RBC) invasion by Plasmodium merozoites requires multiple steps that are regulated by signaling pathways. Exposure of P. falciparum merozoites to the physiological signal of low K+, as found in blood plasma, ... -
Precision Medicine in Pancreatic Disease-Knowledge Gaps and Research Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.
Lowe, ME; Andersen, DK; Caprioli, RM; Choudhary, J; Cruz-Monserrate, Z; et al. (2019-11)A workshop on research gaps and opportunities for Precision Medicine in Pancreatic Disease was sponsored by the National Institute of Diabetes and Digestive Kidney Diseases on July 24, 2019, in Pittsburgh. The workshop ... -
Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression.
Chen, Y-J; Roumeliotis, TI; Chang, Y-H; Chen, C-T; Han, C-L; et al. (CELL PRESS, 2020-07-09)Lung cancer in East Asia is characterized by a high percentage of never-smokers, early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this demographically distinct disease, we performed a ... -
Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome
Abdi, A; Yu, L; Goulding, D; Rono, M; Bejon, P; et al. (2017-11-22)Background : Many pathogens secrete effector molecules to subvert host immune responses, to acquire nutrients, and/or to prepare host cells for invasion. One of the ways that effector molecules are secreted is through ... -
Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyan clinical isolate defines a core parasite secretome.
Abdi, A; Yu, L; Goulding, D; Rono, MK; Bejon, P; et al. (F1000 Research Ltd, 2017-11-22)BACKGROUND: Many pathogens secrete effector molecules to subvert host immune responses, to acquire nutrients, and/or to prepare host cells for invasion. One of the ways that effector molecules are secreted is through ... -
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines.
Cano-Gamez, E; Soskic, B; Roumeliotis, TI; So, E; Smyth, DJ; et al. (NATURE RESEARCH, 2020-04-14)Naïve CD4+ T cells coordinate the immune response by acquiring an effector phenotype in response to cytokines. However, the cytokine responses in memory T cells remain largely understudied. Here we use quantitative proteomics, ... -
Study of Plasmodium falciparum DHHC palmitoyl transferases identifies a role for PfDHHC9 in gametocytogenesis.
Tay, CL; Jones, ML; Hodson, N; Theron, M; Choudhary, JS; et al. (WILEY, 2016-11-01)Palmitoylation is the post-translational reversible addition of the acyl moiety, palmitate, to cysteine residues of proteins and is involved in regulating protein trafficking, localization, stability and function. The ... -
Sub-minute Phosphoregulation of Cell Cycle Systems during Plasmodium Gamete Formation.
Invergo, BM; Brochet, M; Yu, L; Choudhary, J; Beltrao, P; et al. (CELL PRESS, 2017-11-14)The transmission of malaria parasites to mosquitoes relies on the rapid induction of sexual reproduction upon their ingestion into a blood meal. Haploid female and male gametocytes become activated and emerge from their ... -
Targeted Feature Detection for Data-Dependent Shotgun Proteomics.
Weisser, H; Choudhary, JS (AMER CHEMICAL SOC, 2017-08-04)Label-free quantification of shotgun LC-MS/MS data is the prevailing approach in quantitative proteomics but remains computationally nontrivial. The central data analysis step is the detection of peptide-specific signal ... -
Transcriptome and proteome analysis of Salmonella enterica serovar Typhimurium systemic infection of wild type and immune-deficient mice.
Oshota, O; Conway, M; Fookes, M; Schreiber, F; Chaudhuri, RR; et al. (PUBLIC LIBRARY SCIENCE, 2017-08-10)Salmonella enterica are a threat to public health. Current vaccines are not fully effective. The ability to grow in infected tissues within phagocytes is required for S. enterica virulence in systemic disease. As the ... -
Widespread epigenomic, transcriptomic and proteomic differences between hip osteophytic and articular chondrocytes in osteoarthritis.
Steinberg, J; Brooks, RA; Southam, L; Bhatnagar, S; Roumeliotis, TI; et al. (OXFORD UNIV PRESS, 2018-08-01)OBJECTIVES: To identify molecular differences between chondrocytes from osteophytic and articular cartilage tissue from OA patients. METHODS: We investigated genes and pathways by combining genome-wide DNA methylation, RNA ...