Browsing Other ICR Research by title
Now showing items 151-170 of 1078
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c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3
(NATURE PUBLISHING GROUP, 2007-08-08)During T-cell development, thymocytes with intermediate avidity for antigen-MHC complexes are positively selected and then differentiate into functional cytotoxic and helper T cells. This process is controlled by signalling ... -
c-myb transcription is activated by protein kinase B (PKB) following interleukin 2 stimulation of T cells and is required for PKB-mediated protection from apoptosis
(AMER SOC MICROBIOLOGY, 2001-09)During T-cell activation, c-Myb is induced upon interleukin 2 (IL-2) stimulation and is required for correct proliferation of cells. In this paper, we provide evidence that IL-2-mediated induction of the c-myb gene occurs ... -
Calculation of x-ray spectra emerging from an x-ray tube. Part II. X-ray production and filtration in x-ray targets
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2007-06)A new approach to the calculation of the x-ray spectrum emerging from an x-ray tube is proposed. Theoretical results for the bremsstrahlung cross section appearing in the literature are summarized. Four different treatments ... -
Calibration of CT Hounsfield units for radiotherapy treatment planning of patients with metallic hip prostheses: the use of the extended CT-scale
(IOP PUBLISHING LTD, 2003-06-07)Heterogeneity corrections for radiotherapy dose calculations are based on the electron density of the disturbing heterogeneity. However, when CT planning a radiotherapy treatment, where metallic hip implants are present, ... -
Can self-management programmes change healthcare utilisation in COPD?: A systematic review and framework analysis.
Objective The study aims to evaluate the ability of self-management programmes to change the healthcare-seeking behaviours of people with Chronic Obstructive Pulmonary Disease (COPD), and any associations between programme ... -
Cancer across the tree of life: cooperation and cheating in multicellularity
(2015-07)Multicellularity is characterized by cooperation among cells for the development, maintenance and reproduction of the multicellular organism. Cancer can be viewed as cheating within this cooperative multicellular system. ... -
Cancer care in the developed world: A comparison of surgical oncology training programs
(Elsevier BV, 2018-01) -
Cancer epidemiology in the last century and the next decade
(MACMILLAN PUBLISHERS LTD, 2001-05-17)By the early 1980s, epidemiologists had identified many important causes of cancer. They had also proposed the ‘multi-stage’ model of cancer, although none of the hypothesized events in human carcinogenesis had then been ... -
Cancer genetics and reproduction
(ELSEVIER SCI LTD, 2010-02)Cancers of the reproductive organs (i.e., ovaries, uterus and testes), like other cancers, occur as a result of a multi-stage interaction of genetic and environmental factors. A small proportion of cancers of the reproductive ... -
Cancer survival is dependent on season of diagnosis and sunlight exposure
(WILEY-LISS, 2006-10-01)Sunlight is essential for the production of vitamin D in the body. Evidence exists to suggest that vitamin D metabolites may have a role in tumor growth suppression. In this large study, involving over a million cancer ... -
Cancer Variant Interpretation Group UK (CanVIG-UK): an exemplar national subspecialty multidisciplinary network.
(2020-12)Advances in technology have led to a massive expansion in the capacity for genomic analysis, with a commensurate fall in costs. The clinical indications for genomic testing have evolved markedly; the volume of clinical ... -
Carcinoma of the cervix and tobacco smoking: Collaborative reanalysis of individual data on 13,541 women with carcinoma of the cervix and 23,017 women without carcinoma of the cervix from 23 epidemiological studies - International collaboration of epidemiological studies of cervical cancer
(WILEY-LISS, 2006-03-15)Tobacco smoking has been classified as a cause of cervical cancer, but the effect of different patterns of smoking on risk is unclear. The International Collaboration of Epidemiological Studies of Cervical Cancer has brought ... -
Care of non-communicable diseases in emergencies
(Elsevier BV, 2017-01) -
Carfilzomib Enhances the Suppressive Effect of Ruxolitinib in Myelofibrosis
As the first FDA-approved tyrosine kinase inhibitor for treatment of patients with myelofibrosis (MF), ruxolitinib improves clinical symptoms but does not lead to eradication of the disease or significant reduction of the ... -
Catch my drift? Making sense of genomic intra-tumour heterogeneity.
(2017-04)The cancer genome is shaped by three components of the evolutionary process: mutation, selection and drift. While many studies have focused on the first two components, the role of drift in cancer evolution has received ... -
CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus
(NATURE PUBLISHING GROUP, 2005-08-25)Control of cell proliferation by Polycomb group proteins (PcG) is an important facet of cellular homeostasis and its disruption can promote tumorigenesis. We recently described CBX7 as a novel PcG protein controlling the ... -
CD25 Blockade Delays Regulatory T Cell Reconstitution and Does Not Prevent Graft-versus-Host Disease After Allogeneic Hematopoietic Cell Transplantation.
(2017-03)Daclizumab, a humanized monoclonal antibody, binds CD25 and blocks formation of the IL-2 receptor on T cells. A study of daclizumab as acute graft-versus-host disease (GVHD) prophylaxis after unrelated bone marrow ... -
Cell-surface receptors enable perception of extracellular cytokinins.
(2020-08-27)Cytokinins are mobile multifunctional plant hormones with roles in development and stress resilience. Although their Histidine Kinase receptors are substantially localised to the endoplasmic reticulum, cellular sites of ... -
Cell-type-specific visualisation and biochemical isolation of endogenous synaptic proteins in mice.
(2020-02)In recent years, the remarkable molecular complexity of synapses has been revealed, with over 1,000 proteins identified in the synapse proteome. Although it is known that different receptors and other synaptic proteins are ...
