Recent submissions
Now showing items 521-540 of 622
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DNA Damage Activates a Spatially Distinct Late Cytoplasmic Cell-Cycle Checkpoint Network Controlled by MK2-Mediated RNA Stabilization
(CELL PRESS, 2010-10-08)Following genotoxic stress, cells activate a complex kinase-based signaling network to arrest the cell cycle and initiate DNA repair. p53-defective tumor cells rewire their checkpoint response and become dependent on the ... -
Activation of Aurora-A Kinase by Protein Partner Binding and Phosphorylation Are Independent and Synergistic
(AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2012-01-06)Protein kinases are activated by phosphorylation and by the binding of activator proteins. The interplay of these two factors is incompletely understood. We applied energetic analysis to this question and characterized the ... -
The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
(PUBLIC LIBRARY SCIENCE, 2013-01-25)Telomerase is a multi-subunit enzyme that reverse transcribes telomere repeats onto the ends of linear eukaryotic chromosomes and is therefore critical for genome stability. S. cerevisiae telomerase activity is cell-cycle ... -
Does Body Contouring After Bariatric Weight Loss Enhance Quality of Life? A Systematic Review of QOL Studies.
(2018-10)Massive weight loss following bariatric surgery can result in excess tissue, manifesting as large areas of redundant skin that can be managed by body contouring surgery. This study aims to quantify the effects of body ... -
Optical photon transport in powdered-phosphor scintillators. Part II. Calculation of single-scattering transport parameters
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2013-04)Purpose: Monte Carlo methods based on the Boltzmann transport equation (BTE) have previously been used to model light transport in powdered-phosphor scintillator screens. Physically motivated guesses or, alternatively, the ... -
Optical photon transport in powdered-phosphor scintillators. Part 1. Multiple-scattering and validity of the Boltzmann transport equation
(AMER ASSOC PHYSICISTS MEDICINE AMER INST PHYSICS, 2013-04)Purpose: In Part 1 of this two-part work, predictions for light transport in powdered-phosphor screens are made, based on three distinct approaches. Predictions of geometrical optics-based ray tracing through an explicit ... -
Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage
(CELL PRESS, 2013-08-15)Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select functional properties. However, these attributes are not absolute and often overlap, leading to ... -
Second primary cancers in non-Hodgkin lymphoma: Bidirectional analyses suggesting role for immune dysfunction.
(WILEY, 2018-11-15)Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses. It is unlikely that prior therapy is solely responsible for SPC risk. To investigate risk of SPC after diagnosis of non-Hodgkin ... -
Unlocking the potential of retinoic acid in anticancer therapy
(NATURE PUBLISHING GROUP, 2014-11-25)All-trans-retinoic acid (ATRA) is a physiologically active metabolite of vitamin A. Its antitumour activities have been extensively studied in a variety of model systems and clinical trials; however, to date the only ... -
The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase
(NATURE PUBLISHING GROUP, 2015-06-04)Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ... -
Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
(BRITISH INST RADIOLOGY, 2001-06)The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between ... -
Kinetic energy of He atoms in liquid He-4-He-3 mixtures
(AMER PHYSICAL SOC, 2003-12)Deep inelastic neutron scattering measurements on liquid He-3-He-4 mixtures in the normal phase have been performed on the VESUVIO spectrometer at the ISIS pulsed neutron source at exchanged wave vectors of about qsimilar ... -
A comparison between cobalt and linear accelerator-based treatment plans for conformal and intensity-modulated radiotherapy
(BRITISH INST RADIOLOGY, 2008-04)The simplicity of cobalt units gives them the advantage ofreduced maintenance, running costs and downtime when compared with linear accelerators. However, treatments carried out on such units are typically limited to simple ... -
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter
(AMER SOC CLINICAL INVESTIGATION INC, 2010-08)The cytokine TGF-beta acts as a tumor suppressor in normal epithelial cells and during the early stages of tumorigenesis. During malignant progression, cancer cells can switch their response to TGF-beta and use this cytokine ... -
Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
(BIOMED CENTRAL LTD, 2014)The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer ... -
Breast reconstruction and post-mastectomy radiation practice
(BIOMED CENTRAL LTD, 2013-03-02)Purpose: The goal of this study was to explore the perspectives and practice of radiation oncologists who treat breast cancer patients who have had breast reconstruction. Methods: In 2010, an original electronic survey was ... -
Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.
(NATURE PUBLISHING GROUP, 2016-01-01)Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the bioinformatics tools 'expanding ploidy and allele frequency on nested subpopulations' (EXPANDS) and PyClone to detect ... -
Modeling the Subclonal Evolution of Cancer Cell Populations
(2018-02)Increasing evidence shows that tumor clonal architectures are often the consequence of a complex branching process, yet little is known about the expected dynamics and extent to which these divergent subclonal expansions ... -
Fate of the metabolically healthy obese-is this term a misnomer? A study from the Clinical Practice Research Datalink.
(2019-05)INTRODUCTION:The metabolically healthy obese (MHO) phenotype may express typical characteristics on long-term follow-up. Little is known about the initiation of this phenotypes and its future stability. AIM:The Clinical ...