Deciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine

View/ Open
Publication Date
2014ICR Author
Author
Hiley, C
de Bruin, EC
McGranahan, N
Swanton, C
Type
Other
Metadata
Show full item recordAbstract
The presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
Open access location
https://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-014-0453-8Collections
Licenseref URL
http://creativecommons.org/licenses/by/4.0/Version of record
Language
English
License start date
2014
Citation
GENOME BIOLOGY, 2014, 15
Publisher
BIOMED CENTRAL LTD