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dc.contributor.authorHiley, C
dc.contributor.authorde Bruin, EC
dc.contributor.authorMcGranahan, N
dc.contributor.authorSwanton, C
dc.date.accessioned2018-07-23T13:17:59Z
dc.date.issued2014
dc.identifier.citationGENOME BIOLOGY, 2014, 15
dc.identifier.issn1474-760X
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2113
dc.identifier.doi10.1186/s13059-014-0453-8
dc.description.abstractThe presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.
dc.languageeng
dc.language.isoeng
dc.publisherBIOMED CENTRAL LTD
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.titleDeciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicine
dc.typeOther
rioxxterms.versionofrecord10.1186/s13059-014-0453-8
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2014
rioxxterms.typeOther
dc.relation.isPartOfGENOME BIOLOGY
pubs.notesaffiliation: Swanton, C (Reprint Author), Lincolns Inn Fields, Canc Res UK London Res Inst, London WC2A 3LY, England. Hiley, Crispin; Swanton, Charles, Lincolns Inn Fields, Canc Res UK London Res Inst, London WC2A 3LY, England. Hiley, Crispin, Inst Canc Res, London SW7 3RP, England. de Bruin, Elza C.; McGranahan, Nicholas; Swanton, Charles, UCL, Inst Canc, London WC1E 6BT, England. McGranahan, Nicholas, UCL, Ctr Math & Phys Life Sci & Expt Biol CoMPLEX, London WC1E 6BT, England. article-number: 453 keywords-plus: CELL LUNG-CANCER; 21 BREAST CANCERS; TUMOR HETEROGENEITY; PROSTATE-CANCER; GENETIC-HETEROGENEITY; MOLECULAR-MECHANISMS; ACQUIRED-RESISTANCE; COLORECTAL-CANCER; PANCREATIC-CANCER; DRUG-RESISTANCE research-areas: Biotechnology & Applied Microbiology; Genetics & Heredity web-of-science-categories: Biotechnology & Applied Microbiology; Genetics & Heredity author-email: [email protected] orcid-numbers: McGranahan, Nicholas/0000-0001-9537-4045 Swanton, Charles/0000-0002-4299-3018 funding-acknowledgement: National Institute for Health Research Academic Clinical Fellowship; Cancer Research UK; Rosetrees Trust; EU [259303]; Prostate Cancer Foundation; European Research Council; Breast Cancer Research Foundation; National Institute for Health Research University College London Hospital Biomedical Research Centre; Cancer Research UK [17786, 19310] funding-text: ECdB is a Rosetrees Trust fellow, CH is funded by the National Institute for Health Research Academic Clinical Fellowship and CS is funded by Cancer Research UK, the Rosetrees Trust, EU FP7 (projects PREDICT and RESPONSIFY, ID: 259303), the Prostate Cancer Foundation, the European Research Council, the Breast Cancer Research Foundation, and is supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. number-of-cited-references: 69 times-cited: 83 usage-count-last-180-days: 2 usage-count-since-2013: 18 journal-iso: Genome Biol. doc-delivery-number: AW9UU unique-id: ISI:000346604100028 oa: gold da: 2018-07-23
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR
pubs.volume15
pubs.embargo.termsNot known
pubs.oa-locationhttps://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-014-0453-8
dc.contributor.icrauthorHiley, Crispinen


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