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dc.contributor.authorHiley, Cen_US
dc.contributor.authorde Bruin, ECen_US
dc.contributor.authorMcGranahan, Nen_US
dc.contributor.authorSwanton, Cen_US
dc.date.accessioned2018-07-23T13:17:59Z
dc.date.issued2014en_US
dc.identifier.citationGENOME BIOLOGY, 2014, 15en_US
dc.identifier.issn1474-760Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2113
dc.identifier.doi10.1186/s13059-014-0453-8en_US
dc.description.abstractThe presence of multiple subclones within tumors mandates understanding of longitudinal and spatial subclonal dynamics. Resolving the spatial and temporal heterogeneity of subclones with cancer driver events may offer insight into therapy response, tumor evolutionary histories and clinical trial design.en_US
dc.languageEnglishen_US
dc.language.isoEnglishen_US
dc.publisherBIOMED CENTRAL LTDen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleDeciphering intratumor heterogeneity and temporal acquisition of driver events to refine precision medicineen_US
dc.typeOther
rioxxterms.versionofrecord10.1186/s13059-014-0453-8en_US
rioxxterms.licenseref.startdate2014en_US
rioxxterms.typeotheren_US
dc.relation.isPartOfGENOME BIOLOGYen_US
pubs.notesaffiliation: Swanton, C (Reprint Author), Lincolns Inn Fields, Canc Res UK London Res Inst, London WC2A 3LY, England. Hiley, Crispin; Swanton, Charles, Lincolns Inn Fields, Canc Res UK London Res Inst, London WC2A 3LY, England. Hiley, Crispin, Inst Canc Res, London SW7 3RP, England. de Bruin, Elza C.; McGranahan, Nicholas; Swanton, Charles, UCL, Inst Canc, London WC1E 6BT, England. McGranahan, Nicholas, UCL, Ctr Math & Phys Life Sci & Expt Biol CoMPLEX, London WC1E 6BT, England. article-number: 453 keywords-plus: CELL LUNG-CANCER; 21 BREAST CANCERS; TUMOR HETEROGENEITY; PROSTATE-CANCER; GENETIC-HETEROGENEITY; MOLECULAR-MECHANISMS; ACQUIRED-RESISTANCE; COLORECTAL-CANCER; PANCREATIC-CANCER; DRUG-RESISTANCE research-areas: Biotechnology & Applied Microbiology; Genetics & Heredity web-of-science-categories: Biotechnology & Applied Microbiology; Genetics & Heredity author-email: Charles.swanton@cancer.org.uk orcid-numbers: McGranahan, Nicholas/0000-0001-9537-4045 Swanton, Charles/0000-0002-4299-3018 funding-acknowledgement: National Institute for Health Research Academic Clinical Fellowship; Cancer Research UK; Rosetrees Trust; EU [259303]; Prostate Cancer Foundation; European Research Council; Breast Cancer Research Foundation; National Institute for Health Research University College London Hospital Biomedical Research Centre; Cancer Research UK [17786, 19310] funding-text: ECdB is a Rosetrees Trust fellow, CH is funded by the National Institute for Health Research Academic Clinical Fellowship and CS is funded by Cancer Research UK, the Rosetrees Trust, EU FP7 (projects PREDICT and RESPONSIFY, ID: 259303), the Prostate Cancer Foundation, the European Research Council, the Breast Cancer Research Foundation, and is supported by the National Institute for Health Research University College London Hospital Biomedical Research Centre. number-of-cited-references: 69 times-cited: 83 usage-count-last-180-days: 2 usage-count-since-2013: 18 journal-iso: Genome Biol. doc-delivery-number: AW9UU unique-id: ISI:000346604100028 oa: gold da: 2018-07-23en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.volume15en_US
pubs.embargo.termsNot knownen_US
pubs.oa-locationhttps://genomebiology.biomedcentral.com/track/pdf/10.1186/s13059-014-0453-8en_US
dc.contributor.icrauthorHiley, Crispinen_US


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