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dc.contributor.authorJohnson, Nen_US
dc.contributor.authorDudbridge, Fen_US
dc.contributor.authorOrr, Nen_US
dc.contributor.authorGibson, Len_US
dc.contributor.authorJones, MEen_US
dc.contributor.authorSchoemaker, MJen_US
dc.contributor.authorFolkerd, EJen_US
dc.contributor.authorHaynes, BPen_US
dc.contributor.authorHopper, JLen_US
dc.contributor.authorSouthey, MCen_US
dc.contributor.authorDite, GSen_US
dc.contributor.authorApicella, Cen_US
dc.contributor.authorSchmidt, MKen_US
dc.contributor.authorBroeks, Aen_US
dc.contributor.authorVan't Veer, LJen_US
dc.contributor.authorAtsma, Fen_US
dc.contributor.authorMuir, Ken_US
dc.contributor.authorLophatananon, Aen_US
dc.contributor.authorFasching, PAen_US
dc.contributor.authorBeckmann, MWen_US
dc.contributor.authorEkici, ABen_US
dc.contributor.authorRenner, SPen_US
dc.contributor.authorSawyer, Een_US
dc.contributor.authorTomlinson, Ien_US
dc.contributor.authorKerin, Men_US
dc.contributor.authorMiller, Nen_US
dc.contributor.authorBurwinkel, Ben_US
dc.contributor.authorMarme, Fen_US
dc.contributor.authorSchneeweiss, Aen_US
dc.contributor.authorSohn, Cen_US
dc.contributor.authorGuénel, Pen_US
dc.contributor.authorTruong, Ten_US
dc.contributor.authorCordina, Een_US
dc.contributor.authorMenegaux, Fen_US
dc.contributor.authorBojesen, SEen_US
dc.contributor.authorNordestgaard, BGen_US
dc.contributor.authorFlyger, Hen_US
dc.contributor.authorMilne, Ren_US
dc.contributor.authorZamora, MPen_US
dc.contributor.authorArias Perez, JIen_US
dc.contributor.authorBenitez, Jen_US
dc.contributor.authorBernstein, Len_US
dc.contributor.authorAnton-Culver, Hen_US
dc.contributor.authorZiogas, Aen_US
dc.contributor.authorClarke Dur, Cen_US
dc.contributor.authorBrenner, Hen_US
dc.contributor.authorMüller, Hen_US
dc.contributor.authorArndt, Ven_US
dc.contributor.authorDieffenbach, AKen_US
dc.contributor.authorMeindl, Aen_US
dc.contributor.authorHeil, Jen_US
dc.contributor.authorBartram, CRen_US
dc.contributor.authorSchmutzler, RKen_US
dc.contributor.authorBrauch, Hen_US
dc.contributor.authorJustenhoven, Cen_US
dc.contributor.authorKo, YDen_US
dc.contributor.authorNevanlinna, Hen_US
dc.contributor.authorMuranen, TAen_US
dc.contributor.authorAittomäki, Ken_US
dc.contributor.authorBlomqvist, Cen_US
dc.contributor.authorMatsuo, Ken_US
dc.contributor.authorDörk, Ten_US
dc.contributor.authorBogdanova, NVen_US
dc.contributor.authorAntonenkova, NNen_US
dc.contributor.authorLindblom, Aen_US
dc.contributor.authorMannermaa, Aen_US
dc.contributor.authorKataja, Ven_US
dc.contributor.authorKosma, VMen_US
dc.contributor.authorHartikainen, JMen_US
dc.contributor.authorChenevix-Trench, Gen_US
dc.contributor.authorBeesley, Jen_US
dc.contributor.authorWu, AHen_US
dc.contributor.authorVan den Berg, Den_US
dc.contributor.authorTseng, CCen_US
dc.contributor.authorLambrechts, Den_US
dc.contributor.authorSmeets, Den_US
dc.contributor.authorNeven, Pen_US
dc.contributor.authorWildiers, Hen_US
dc.contributor.authorChang-Claude, Jen_US
dc.contributor.authorRudolph, Aen_US
dc.contributor.authorNickels, Sen_US
dc.contributor.authorFlesch-Janys, Den_US
dc.contributor.authorRadice, Pen_US
dc.contributor.authorPeterlongo, Pen_US
dc.contributor.authorBonanni, Ben_US
dc.contributor.authorPensotti, Ven_US
dc.contributor.authorCouch, FJen_US
dc.contributor.authorOlson, JEen_US
dc.contributor.authorWang, Xen_US
dc.contributor.authorFredericksen, Zen_US
dc.contributor.authorPankratz, VSen_US
dc.contributor.authorGiles, GGen_US
dc.contributor.authorSeveri, Gen_US
dc.contributor.authorBaglietto, Len_US
dc.contributor.authorHaiman, Cen_US
dc.contributor.authorSimard, Jen_US
dc.contributor.authorGoldberg, MSen_US
dc.contributor.authorLabrèche, Fen_US
dc.contributor.authorDumont, Men_US
dc.contributor.authorSoucy, Pen_US
dc.contributor.authorTeo, Sen_US
dc.contributor.authorYip, CHen_US
dc.contributor.authorPhuah, SYen_US
dc.contributor.authorCornes, BKen_US
dc.contributor.authorKristensen, VNen_US
dc.contributor.authorGrenaker Alnæs, Gen_US
dc.contributor.authorBørresen-Dale, ALen_US
dc.contributor.authorZheng, Wen_US
dc.contributor.authorWinqvist, Ren_US
dc.contributor.authorPylkäs, Ken_US
dc.contributor.authorJukkola-Vuorinen, Aen_US
dc.contributor.authorGrip, Men_US
dc.contributor.authorAndrulis, ILen_US
dc.contributor.authorKnight, JAen_US
dc.contributor.authorGlendon, Gen_US
dc.contributor.authorMulligan, AMen_US
dc.contributor.authorDevillee, Pen_US
dc.contributor.authorFigueroa, Jen_US
dc.contributor.authorChanock, SJen_US
dc.contributor.authorLissowska, Jen_US
dc.contributor.authorSherman, MEen_US
dc.contributor.authorHall, Pen_US
dc.contributor.authorSchoof, Nen_US
dc.contributor.authorHooning, Men_US
dc.contributor.authorHollestelle, Aen_US
dc.contributor.authorOldenburg, RAen_US
dc.contributor.authorTilanus-Linthorst, Men_US
dc.contributor.authorLiu, Jen_US
dc.contributor.authorCox, Aen_US
dc.contributor.authorBrock, IWen_US
dc.contributor.authorReed, MWen_US
dc.contributor.authorCross, SSen_US
dc.contributor.authorBlot, Wen_US
dc.contributor.authorSignorello, LBen_US
dc.contributor.authorPharoah, PDen_US
dc.contributor.authorDunning, AMen_US
dc.contributor.authorShah, Men_US
dc.contributor.authorKang, Den_US
dc.contributor.authorNoh, DYen_US
dc.contributor.authorPark, SKen_US
dc.contributor.authorChoi, JYen_US
dc.contributor.authorHartman, Men_US
dc.contributor.authorMiao, Hen_US
dc.contributor.authorLim, WYen_US
dc.contributor.authorTang, Aen_US
dc.contributor.authorHamann, Uen_US
dc.contributor.authorFörsti, Aen_US
dc.contributor.authorRüdiger, Ten_US
dc.contributor.authorUlmer, HUen_US
dc.contributor.authorJakubowska, Aen_US
dc.contributor.authorLubinski, Jen_US
dc.contributor.authorJaworska-Bieniek, Ken_US
dc.contributor.authorDurda, Ken_US
dc.contributor.authorSangrajrang, Sen_US
dc.contributor.authorGaborieau, Ven_US
dc.contributor.authorBrennan, Pen_US
dc.contributor.authorMcKay, Jen_US
dc.contributor.authorSlager, Sen_US
dc.contributor.authorToland, AEen_US
dc.contributor.authorVachon, Cen_US
dc.contributor.authorYannoukakos, Den_US
dc.contributor.authorShen, CYen_US
dc.contributor.authorYu, JCen_US
dc.contributor.authorHuang, CSen_US
dc.contributor.authorHou, MFen_US
dc.contributor.authorGonzález-Neira, Aen_US
dc.contributor.authorTessier, DCen_US
dc.contributor.authorVincent, Den_US
dc.contributor.authorBacot, Fen_US
dc.contributor.authorLuccarini, Cen_US
dc.contributor.authorDennis, Jen_US
dc.contributor.authorMichailidou, Ken_US
dc.contributor.authorBolla, MKen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorEaston, DFen_US
dc.contributor.authorGarcía-Closas, Men_US
dc.contributor.authorDowsett, Men_US
dc.contributor.authorAshworth, Aen_US
dc.contributor.authorSwerdlow, AJen_US
dc.contributor.authorPeto, Jen_US
dc.contributor.authordos Santos Silva, Ien_US
dc.contributor.authorFletcher, Oen_US
dc.date.accessioned2016-09-28T14:43:48Z
dc.date.issued2014-01en_US
dc.identifier.citationBreast cancer research : BCR, 2014, 16 (3), pp. R51 - ?en_US
dc.identifier.issn1465-5411en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/154
dc.identifier.eissn1465-542Xen_US
dc.identifier.doi10.1186/bcr3662en_US
dc.description.abstractWe have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and a modest reduction in risk of breast cancer in women age ≤50 years.We further investigated the association of rs10235235 with breast cancer risk in a large case control study of 47,346 cases and 47,570 controls from 52 studies participating in the Breast Cancer Association Consortium. Genotyping of rs10235235 was conducted using a custom Illumina Infinium array. Stratified analyses were conducted to determine whether this association was modified by age at diagnosis, ethnicity, age at menarche or tumor characteristics.We confirmed the association of rs10235235 with breast cancer risk for women of European ancestry but found no evidence that this association differed with age at diagnosis. Heterozygote and homozygote odds ratios (ORs) were OR = 0.98 (95% CI 0.94, 1.01; P = 0.2) and OR = 0.80 (95% CI 0.69, 0.93; P = 0.004), respectively (P(trend) = 0.02). There was no evidence of effect modification by tumor characteristics. rs10235235 was, however, associated with age at menarche in controls (P(trend) = 0.005) but not cases (P(trend) = 0.97). Consequently the association between rs10235235 and breast cancer risk differed according to age at menarche (P(het) = 0.02); the rare allele of rs10235235 was associated with a reduction in breast cancer risk for women who had their menarche age ≥15 years (OR(het) = 0.84, 95% CI 0.75, 0.94; OR(hom) = 0.81, 95% CI 0.51, 1.30; P(trend) = 0.002) but not for those who had their menarche age ≤11 years (OR(het) = 1.06, 95% CI 0.95, 1.19, OR(hom) = 1.07, 95% CI 0.67, 1.72; P(trend) = 0.29).To our knowledge rs10235235 is the first single nucleotide polymorphism to be associated with both breast cancer risk and age at menarche consistent with the well-documented association between later age at menarche and a reduction in breast cancer risk. These associations are likely mediated via an effect on circulating hormone levels.en_US
dc.formatElectronicen_US
dc.format.extentR51 - ?en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectGENICA (Gene Environment Interaction and Breast Cancer in Germany) Networken_US
dc.subjectkConFab Investigatorsen_US
dc.subjectAustralian Ovarian Cancer Study Groupen_US
dc.subjectHumansen_US
dc.subjectBreast Neoplasmsen_US
dc.subjectGenetic Predisposition to Diseaseen_US
dc.subjectReproductive Historyen_US
dc.subjectRisk Factorsen_US
dc.subjectAge Factorsen_US
dc.subjectAge of Onseten_US
dc.subjectPremenopauseen_US
dc.subjectMenarcheen_US
dc.subjectGenotypeen_US
dc.subjectPolymorphism, Single Nucleotideen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectEuropean Continental Ancestry Groupen_US
dc.subjectFemaleen_US
dc.subjectCytochrome P-450 CYP3Aen_US
dc.subjectGenetic Association Studiesen_US
dc.titleGenetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study.en_US
dc.typeJournal Article
dcterms.dateAccepted2014-04-24en_US
rioxxterms.versionofrecord10.1186/bcr3662en_US
rioxxterms.licenseref.startdate2014-01en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfBreast cancer research : BCRen_US
pubs.issue3en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Gene Function
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Molecular Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Endocrinology/Endocrinology (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Gene Function
pubs.volume16en_US
pubs.embargo.termsNot knownen_US
icr.researchteamComplex Trait Geneticsen_US
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamMolecular Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamEndocrinologyen_US
icr.researchteamGene Functionen_US
dc.contributor.icrauthorFletcher, Oliviaen_US
dc.contributor.icrauthorFolkerd, Elizabethen_US
dc.contributor.icrauthorSwerdlow, Anthonyen_US
dc.contributor.icrauthorSchoemaker, Minouken_US
dc.contributor.icrauthorJones, Michaelen_US
dc.contributor.icrauthorJohnson, Nicholaen_US
dc.contributor.icrauthorOrr, Nicholasen_US
dc.contributor.icrauthorAshworth, Alanen_US
dc.contributor.icrauthorDowsett, Mitchen_US
dc.contributor.icrauthorGarcia-Closas, Montserraten_US


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