Influence of obesity-related risk factors in the aetiology of glioma.
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Background Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. Methods Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. Results No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. Conclusions This study provides no evidence to implicate obesity-related factors as causes of glioma.
Diabetes Mellitus, Type 2
Genetic Predisposition to Disease
Body Mass Index
Polymorphism, Single Nucleotide
Genome-Wide Association Study
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British journal of cancer, 2018, 118 (7), pp. 1020 - 1027