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dc.contributor.authorKadhum, Men_US
dc.contributor.authorSmock, Een_US
dc.contributor.authorKhan, Aen_US
dc.contributor.authorFleming, Aen_US
dc.coverage.spatialEnglanden_US
dc.date.accessioned2018-04-17T09:02:21Z
dc.date.issued2017-09en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/28490266en_US
dc.identifier.citationJ Hand Surg Eur Vol, 2017, 42 (7), pp. 689 - 692en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/1646
dc.identifier.eissn2043-6289en_US
dc.identifier.doi10.1177/1753193417695996en_US
dc.description.abstractRadiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%. Salvage surgery was successful in all cases of disease progression post-radiotherapy. There were no reports of adverse wound healing problems associated with such surgery or radiotherapy-associated malignancy. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment. LEVEL OF EVIDENCE: II.en_US
dc.format.extent689 - 692en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectDupuytren’s contractureen_US
dc.subjectDupuytren’s diseaseen_US
dc.subjectSystematic reviewen_US
dc.subjectradiation therapyen_US
dc.subjectradiotherapyen_US
dc.subjectsurgeryen_US
dc.subjectDisease Progressionen_US
dc.subjectDupuytren Contractureen_US
dc.subjectHumansen_US
dc.subjectRadiotherapyen_US
dc.titleRadiotherapy in Dupuytren's disease: a systematic review of the evidence.en_US
dc.typeJournal Article
dcterms.dateAccepted2017-02-06en_US
rioxxterms.versionofrecord10.1177/1753193417695996en_US
rioxxterms.licenseref.startdate2017-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfJ Hand Surg Eur Volen_US
pubs.issue7en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.publication-statusPublisheden_US
pubs.volume42en_US
pubs.embargo.termsNot knownen_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorKhan, Aadilen_US


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