dc.contributor.author | Kadhum, M | |
dc.contributor.author | Smock, E | |
dc.contributor.author | Khan, A | |
dc.contributor.author | Fleming, A | |
dc.date.accessioned | 2018-04-17T09:02:21Z | |
dc.date.issued | 2017-09 | |
dc.identifier.citation | The Journal of hand surgery, European volume, 2017, 42 (7), pp. 689 - 692 | |
dc.identifier.issn | 1753-1934 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/1646 | |
dc.identifier.eissn | 2043-6289 | |
dc.identifier.doi | 10.1177/1753193417695996 | |
dc.description.abstract | Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%. Salvage surgery was successful in all cases of disease progression post-radiotherapy. There were no reports of adverse wound healing problems associated with such surgery or radiotherapy-associated malignancy. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment.Level of evidence II. | |
dc.format | Print-Electronic | |
dc.format.extent | 689 - 692 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.rights.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
dc.subject | Humans | |
dc.subject | Disease Progression | |
dc.subject | Radiotherapy | |
dc.subject | Dupuytren Contracture | |
dc.title | Radiotherapy in Dupuytren's disease: a systematic review of the evidence. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-02-06 | |
rioxxterms.versionofrecord | 10.1177/1753193417695996 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2017-09 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | The Journal of hand surgery, European volume | |
pubs.issue | 7 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy | |
pubs.publication-status | Published | |
pubs.volume | 42 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Targeted Therapy | en_US |
dc.contributor.icrauthor | Khan, Aadil | |