Radiotherapy in Dupuytren's disease: a systematic review of the evidence.
View/ Open
Date
2017-09ICR Author
Author
Kadhum, M
Smock, E
Khan, A
Fleming, A
Type
Journal Article
Metadata
Show full item recordAbstract
Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%. Salvage surgery was successful in all cases of disease progression post-radiotherapy. There were no reports of adverse wound healing problems associated with such surgery or radiotherapy-associated malignancy. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment.Level of evidence II.
Collections
Subject
Humans
Disease Progression
Radiotherapy
Dupuytren Contracture
Research team
Targeted Therapy
Language
eng
Date accepted
2017-02-06
License start date
2017-09
Citation
The Journal of hand surgery, European volume, 2017, 42 (7), pp. 689 - 692