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dc.contributor.authorOwen, Cen_US
dc.contributor.authorConstantinidou, Aen_US
dc.contributor.authorMiah, ABen_US
dc.contributor.authorThway, Ken_US
dc.contributor.authorFisher, Cen_US
dc.contributor.authorBenson, Cen_US
dc.contributor.authorZaidi, Sen_US
dc.contributor.authorMessiou, Cen_US
dc.contributor.authorVAN DER Graaf, WTAen_US
dc.contributor.authorJones, RLen_US
dc.coverage.spatialGreeceen_US
dc.date.accessioned2018-11-14T12:11:41Z
dc.date.issued2018-09en_US
dc.identifierhttps://www.ncbi.nlm.nih.gov/pubmed/30194178en_US
dc.identifier38/9/5275en_US
dc.identifier.citationAnticancer Res, 2018, 38 (9), pp. 5275 - 5282en_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2935
dc.identifier.eissn1791-7530en_US
dc.identifier.doi10.21873/anticanres.12853en_US
dc.description.abstractBACKGROUND/AIM: Synovial sarcoma is a soft tissue sarcoma that tends to affect young adults. There are few reports on primary synovial sarcoma of the thyroid and the aim of this study was to document the clinical and pathological features of synovial sarcoma occurring at this site. CASE PRESENTATION: A retrospective review of a prospectively maintained database was performed to identify patients with synovial sarcoma of the thyroid treated at the Royal Marsden Hospital between 2000 and 2017. Five patients were identified that underwent initial surgical management of localized disease. The mean age at presentation was 38 years, and male to female ratio was 4:1. In 3 out of 5 cases, the diagnosis of synovial sarcoma was made on the post-operative excision specimen. Two of these patients were treated at our institution on the development of metastatic disease. We conducted a literature review and identified 12 previously reported cases of synovial sarcoma of the thyroid. CONCLUSION: Synovial sarcoma of the thyroid is rare and can be challenging to diagnose. The clinical presentation is typically indistinguishable from that of thyroid cancer and most cases are diagnosed post-operatively on an excision specimen. The clinical and pathological features are similar to synovial sarcoma arising at other sites. In our experience, the rarity of the diagnosis can lead to difficulty in establishing the correct diagnosis and determining the appropriate treatment pathway. It is important that physicians are aware of this diagnosis to facilitate prompt referral to a specialist centre, for specialist follow-up and treatment which is different to the thyroid cancer pathway.en_US
dc.format.extent5275 - 5282en_US
dc.languageengen_US
dc.language.isoengen_US
dc.rights.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
dc.subjectSynovial sarcomaen_US
dc.subjectdiagnosisen_US
dc.subjectpathologyen_US
dc.subjecttherapyen_US
dc.subjectthyroiden_US
dc.subjectAdolescenten_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectDiagnosis, Differentialen_US
dc.subjectDisease Managementen_US
dc.subjectFemaleen_US
dc.subjectHumansen_US
dc.subjectMaleen_US
dc.subjectMiddle Ageden_US
dc.subjectNeoplasm Metastasisen_US
dc.subjectRetrospective Studiesen_US
dc.subjectSarcoma, Synovialen_US
dc.subjectThyroid Neoplasmsen_US
dc.titleSynovial Sarcoma of the Thyroid Gland, Diagnostic Pitfalls and Clinical Management.en_US
dc.typeJournal Article
dcterms.dateAccepted2018-08-21en_US
rioxxterms.versionofrecord10.21873/anticanres.12853en_US
rioxxterms.licenseref.startdate2018-09en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfAnticancer Resen_US
pubs.issue9en_US
pubs.notesNot knownen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Clinical Studies/Sarcoma Clinical Trials (R Jones)/Sarcoma Clinical Trials (R Jones) (hon.)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Targeted Therapy
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublisheden_US
pubs.volume38en_US
pubs.embargo.termsNot knownen_US
icr.researchteamSarcoma Clinical Trials (R Jones)en_US
icr.researchteamTargeted Therapyen_US
dc.contributor.icrauthorZaidi, Shane Haideren_US
dc.contributor.icrauthorJones, Robinen_US
dc.contributor.icrauthorMessiou, Christinaen_US


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