Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Cancer Biology
  • View item
  • Home
  • ICR Divisions
  • Cancer Biology
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Synovial Sarcoma of the Thyroid Gland, Diagnostic Pitfalls and Clinical Management.

Thumbnail
View/Open
Published version (192.0Kb)
Date
2018-09
ICR Author
Fisher, Cyril
Zaidi, Shane Haider
Messiou, Christina
Jones, Robin
Author
Owen, C
Constantinidou, A
Miah, AB
Thway, K
Fisher, C
Benson, C
Zaidi, S
Messiou, C
VAN DER Graaf, WTA
Jones, RL
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
Background/aim Synovial sarcoma is a soft tissue sarcoma that tends to affect young adults. There are few reports on primary synovial sarcoma of the thyroid and the aim of this study was to document the clinical and pathological features of synovial sarcoma occurring at this site.Case presentation A retrospective review of a prospectively maintained database was performed to identify patients with synovial sarcoma of the thyroid treated at the Royal Marsden Hospital between 2000 and 2017. Five patients were identified that underwent initial surgical management of localized disease. The mean age at presentation was 38 years, and male to female ratio was 4:1. In 3 out of 5 cases, the diagnosis of synovial sarcoma was made on the post-operative excision specimen. Two of these patients were treated at our institution on the development of metastatic disease. We conducted a literature review and identified 12 previously reported cases of synovial sarcoma of the thyroid.Conclusion Synovial sarcoma of the thyroid is rare and can be challenging to diagnose. The clinical presentation is typically indistinguishable from that of thyroid cancer and most cases are diagnosed post-operatively on an excision specimen. The clinical and pathological features are similar to synovial sarcoma arising at other sites. In our experience, the rarity of the diagnosis can lead to difficulty in establishing the correct diagnosis and determining the appropriate treatment pathway. It is important that physicians are aware of this diagnosis to facilitate prompt referral to a specialist centre, for specialist follow-up and treatment which is different to the thyroid cancer pathway.
URI
https://repository.icr.ac.uk/handle/internal/2935
DOI
https://doi.org/10.21873/anticanres.12853
Collections
  • Cancer Biology
  • Clinical Studies
  • Radiotherapy and Imaging
Subject
Humans
Sarcoma, Synovial
Thyroid Neoplasms
Neoplasm Metastasis
Diagnosis, Differential
Retrospective Studies
Adolescent
Adult
Aged
Middle Aged
Disease Management
Female
Male
Research team
Sarcoma Clinical Trials (R Jones)
Targeted Therapy
Language
eng
Date accepted
2018-08-21
License start date
2018-09
Citation
Anticancer research, 2018, 38 (9), pp. 5275 - 5282

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.