dc.contributor.author | Went, M | |
dc.contributor.author | Sud, A | |
dc.contributor.author | Speedy, H | |
dc.contributor.author | Sunter, NJ | |
dc.contributor.author | Försti, A | |
dc.contributor.author | Law, PJ | |
dc.contributor.author | Johnson, DC | |
dc.contributor.author | Mirabella, F | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Li, N | |
dc.contributor.author | Orlando, G | |
dc.contributor.author | Weinhold, N | |
dc.contributor.author | van Duin, M | |
dc.contributor.author | Chen, B | |
dc.contributor.author | Mitchell, JS | |
dc.contributor.author | Mansouri, L | |
dc.contributor.author | Juliusson, G | |
dc.contributor.author | Smedby, KE | |
dc.contributor.author | Jayne, S | |
dc.contributor.author | Majid, A | |
dc.contributor.author | Dearden, C | |
dc.contributor.author | Allsup, DJ | |
dc.contributor.author | Bailey, JR | |
dc.contributor.author | Pratt, G | |
dc.contributor.author | Pepper, C | |
dc.contributor.author | Fegan, C | |
dc.contributor.author | Rosenquist, R | |
dc.contributor.author | Kuiper, R | |
dc.contributor.author | Stephens, OW | |
dc.contributor.author | Bertsch, U | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Einsele, H | |
dc.contributor.author | Gregory, WM | |
dc.contributor.author | Hillengass, J | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Jackson, GH | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | Nickel, J | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | da Silva Filho, MI | |
dc.contributor.author | Thomsen, H | |
dc.contributor.author | Walker, BA | |
dc.contributor.author | Broyl, A | |
dc.contributor.author | Davies, FE | |
dc.contributor.author | Hansson, M | |
dc.contributor.author | Goldschmidt, H | |
dc.contributor.author | Dyer, MJS | |
dc.contributor.author | Kaiser, M | |
dc.contributor.author | Sonneveld, P | |
dc.contributor.author | Morgan, GJ | |
dc.contributor.author | Hemminki, K | |
dc.contributor.author | Nilsson, B | |
dc.contributor.author | Catovsky, D | |
dc.contributor.author | Allan, JM | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2019-01-02T14:07:33Z | |
dc.date.issued | 2018-12-21 | |
dc.identifier.citation | Blood cancer journal, 2018, 9 (1), pp. 1 - ? | |
dc.identifier.issn | 2044-5385 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2988 | |
dc.identifier.eissn | 2044-5385 | |
dc.identifier.doi | 10.1038/s41408-018-0162-8 | |
dc.description.abstract | The clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (Rg = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies. | |
dc.format | Electronic | |
dc.format.extent | 1 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Multiple Myeloma | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Case-Control Studies | |
dc.subject | Organ Specificity | |
dc.subject | Linkage Disequilibrium | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Quantitative Trait Loci | |
dc.subject | Databases, Genetic | |
dc.subject | Leukemia, Lymphocytic, Chronic, B-Cell | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Association Studies | |
dc.subject | Genetic Linkage | |
dc.title | Genetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-11-19 | |
rioxxterms.versionofrecord | 10.1038/s41408-018-0162-8 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2018-12-21 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Blood cancer journal | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group | |
pubs.organisational-group | /ICR/Students | |
pubs.organisational-group | /ICR/Students/PhD and MPhil | |
pubs.organisational-group | /ICR/Students/PhD and MPhil/16/17 Starting Cohort | |
pubs.publication-status | Published | |
pubs.volume | 9 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Myeloma Group | |
dc.contributor.icrauthor | Went, Molly | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Johnson, David | |
dc.contributor.icrauthor | Holroyd, Amy | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Kaiser, Martin | |
dc.contributor.icrauthor | Houlston, Richard | |