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dc.contributor.authorWent, M
dc.contributor.authorSud, A
dc.contributor.authorSpeedy, H
dc.contributor.authorSunter, NJ
dc.contributor.authorFörsti, A
dc.contributor.authorLaw, PJ
dc.contributor.authorJohnson, DC
dc.contributor.authorMirabella, F
dc.contributor.authorHolroyd, A
dc.contributor.authorLi, N
dc.contributor.authorOrlando, G
dc.contributor.authorWeinhold, N
dc.contributor.authorvan Duin, M
dc.contributor.authorChen, B
dc.contributor.authorMitchell, JS
dc.contributor.authorMansouri, L
dc.contributor.authorJuliusson, G
dc.contributor.authorSmedby, KE
dc.contributor.authorJayne, S
dc.contributor.authorMajid, A
dc.contributor.authorDearden, C
dc.contributor.authorAllsup, DJ
dc.contributor.authorBailey, JR
dc.contributor.authorPratt, G
dc.contributor.authorPepper, C
dc.contributor.authorFegan, C
dc.contributor.authorRosenquist, R
dc.contributor.authorKuiper, R
dc.contributor.authorStephens, OW
dc.contributor.authorBertsch, U
dc.contributor.authorBroderick, P
dc.contributor.authorEinsele, H
dc.contributor.authorGregory, WM
dc.contributor.authorHillengass, J
dc.contributor.authorHoffmann, P
dc.contributor.authorJackson, GH
dc.contributor.authorJöckel, K-H
dc.contributor.authorNickel, J
dc.contributor.authorNöthen, MM
dc.contributor.authorda Silva Filho, MI
dc.contributor.authorThomsen, H
dc.contributor.authorWalker, BA
dc.contributor.authorBroyl, A
dc.contributor.authorDavies, FE
dc.contributor.authorHansson, M
dc.contributor.authorGoldschmidt, H
dc.contributor.authorDyer, MJS
dc.contributor.authorKaiser, M
dc.contributor.authorSonneveld, P
dc.contributor.authorMorgan, GJ
dc.contributor.authorHemminki, K
dc.contributor.authorNilsson, B
dc.contributor.authorCatovsky, D
dc.contributor.authorAllan, JM
dc.contributor.authorHoulston, RS
dc.date.accessioned2019-01-02T14:07:33Z
dc.date.issued2018-12-21
dc.identifier.citationBlood cancer journal, 2018, 9 (1), pp. 1 - ?
dc.identifier.issn2044-5385
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/2988
dc.identifier.eissn2044-5385en_US
dc.identifier.doi10.1038/s41408-018-0162-8en_US
dc.description.abstractThe clustering of different types of B-cell malignancies in families raises the possibility of shared aetiology. To examine this, we performed cross-trait linkage disequilibrium (LD)-score regression of multiple myeloma (MM) and chronic lymphocytic leukaemia (CLL) genome-wide association study (GWAS) data sets, totalling 11,734 cases and 29,468 controls. A significant genetic correlation between these two B-cell malignancies was shown (R<sub>g</sub> = 0.4, P = 0.0046). Furthermore, four of the 45 known CLL risk loci were shown to associate with MM risk and five of the 23 known MM risk loci associate with CLL risk. By integrating eQTL, Hi-C and ChIP-seq data, we show that these pleiotropic risk loci are enriched for B-cell regulatory elements and implicate B-cell developmental genes. These data identify shared biological pathways influencing the development of CLL and, MM and further our understanding of the aetiological basis of these B-cell malignancies.
dc.formatElectronic
dc.format.extent1 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHumans
dc.subjectMultiple Myeloma
dc.subjectGenetic Predisposition to Disease
dc.subjectCase-Control Studies
dc.subjectOrgan Specificity
dc.subjectLinkage Disequilibrium
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectQuantitative Trait Loci
dc.subjectDatabases, Genetic
dc.subjectLeukemia, Lymphocytic, Chronic, B-Cell
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Association Studies
dc.subjectGenetic Linkage
dc.titleGenetic correlation between multiple myeloma and chronic lymphocytic leukaemia provides evidence for shared aetiology.
dc.typeJournal Article
dcterms.dateAccepted2018-11-19
rioxxterms.versionofrecord10.1038/s41408-018-0162-8
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2018-12-21en_US
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBlood cancer journal
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Myeloma Group
pubs.organisational-group/ICR/Students
pubs.organisational-group/ICR/Students/PhD and MPhil
pubs.organisational-group/ICR/Students/PhD and MPhil/16/17 Starting Cohort
pubs.publication-statusPublished
pubs.volume9en_US
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
icr.researchteamMyeloma Groupen_US
dc.contributor.icrauthorHolroyd, Amyen
dc.contributor.icrauthorWent, Mollyen
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorJohnson, Daviden
dc.contributor.icrauthorBroderick, Peteren
dc.contributor.icrauthorKaiser, Martinen
dc.contributor.icrauthorLaw, Philipen
dc.contributor.icrauthorSud, Amiten


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