Now showing items 1-15 of 15

    • Asparagine bioavailability governs metastasis in a model of breast cancer. 

      Knott, SRV; Wagenblast, E; Khan, S; Kim, SY; Soto, M; Wagner, M; Turgeon, M-O; Fish, L; Erard, N; Gable, AL; Maceli, AR; Dickopf, S; Papachristou, EK; D'Santos, CS; Carey, LA; Wilkinson, JE; Harrell, JC; Perou, CM; Goodarzi, H; Poulogiannis, G; Hannon, GJ (2018-02-07)
      Using a functional model of breast cancer heterogeneity, we previously showed that clonal sub-populations proficient at generating circulating tumour cells were not all equally capable of forming metastases at secondary ...
    • Decreased function of survival motor neuron protein impairs endocytic pathways. 

      Dimitriadi, M; Derdowski, A; Kalloo, G; Maginnis, MS; O'Hern, P; Bliska, B; Sorkaç, A; Nguyen, KCQ; Cook, SJ; Poulogiannis, G; Atwood, WJ; Hall, DH; Hart, AC (2016-07-11)
      Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of ...
    • Discovery of naturally occurring ESR1 mutations in breast cancer cell lines modelling endocrine resistance. 

      Martin, L-A; Ribas, R; Simigdala, N; Schuster, E; Pancholi, S; Tenev, T; Gellert, P; Buluwela, L; Harrod, A; Thornhill, A; Nikitorowicz-Buniak, J; Bhamra, A; Turgeon, M-O; Poulogiannis, G; Gao, Q; Martins, V; Hills, M; Garcia-Murillas, I; Fribbens, C; Patani, N; Li, Z; Sikora, MJ; Turner, N; Zwart, W; Oesterreich, S; Carroll, J; Ali, S; Dowsett, M (2017-11-30)
      Resistance to endocrine therapy remains a major clinical problem in breast cancer. Genetic studies highlight the potential role of estrogen receptor-α (ESR1) mutations, which show increased prevalence in the metastatic, ...
    • DNA Damage, Repair, and Cancer Metabolism. 

      Turgeon, M-O; Perry, NJS; Poulogiannis, G (2018-01)
      Although there has been a renewed interest in the field of cancer metabolism in the last decade, the link between metabolism and DNA damage/DNA repair in cancer has yet to be appreciably explored. In this review, we examine ...
    • Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment. 

      Ip, LRH; Poulogiannis, G; Viciano, FC; Sasaki, J; Kofuji, S; Spanswick, VJ; Hochhauser, D; Hartley, JA; Sasaki, T; Gewinner, CA (2015-04)
      Treatment options for ovarian cancer patients remain limited and overall survival is less than 50% despite recent clinical advances. The lipid phosphatase inositol polyphosphate 4-phosphatase type II (INPP4B) has been ...
    • Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. 

      van Weverwijk, A; Koundouros, N; Iravani, M; Ashenden, M; Gao, Q; Poulogiannis, G; Jungwirth, U; Isacke, CM (2019-06-20)
      The different stages of the metastatic cascade present distinct metabolic challenges to tumour cells and an altered tumour metabolism associated with successful metastatic colonisation provides a therapeutic vulnerability ...
    • Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids. 

      Koundouros, N; Karali, E; Tripp, A; Valle, A; Inglese, P; Perry, NJS; Magee, DJ; Anjomani Virmouni, S; Elder, GA; Tyson, AL; Dória, ML; van Weverwijk, A; Soares, RF; Isacke, CM; Nicholson, JK; Glen, RC; Takats, Z; Poulogiannis, G (2020-06-18)
      Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife ...
    • Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. 

      Tape, CJ; Ling, S; Dimitriadi, M; McMahon, KM; Worboys, JD; Leong, HS; Norrie, IC; Miller, CJ; Poulogiannis, G; Lauffenburger, DA; Jørgensen, C (2016-06)
    • Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation. 

      Tape, CJ; Ling, S; Dimitriadi, M; McMahon, KM; Worboys, JD; Leong, HS; Norrie, IC; Miller, CJ; Poulogiannis, G; Lauffenburger, DA; Jørgensen, C (2016-05)
      Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS(G12D)) also regulates tumor cell signaling via stromal cells. By combining cell-specific ...
    • PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. 

      Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Dimitriadi, M; Choo-Wing, R; Valle, A; Zheng, Y; Chiu, Y-H; Agnihotri, S; Zadeh, G; Asara, JM; Anastasiou, D; Arends, MJ; Cantley, LC; Poulogiannis, G (2017-03)
      PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all ...
    • PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. 

      Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Poulogiannis, G (2017-01)
      Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss ...
    • Perioperative events influence cancer recurrence risk after surgery. 

      Hiller, JG; Perry, NJ; Poulogiannis, G; Riedel, B; Sloan, EK (2018-04)
      Surgery is a mainstay treatment for patients with solid tumours. However, despite surgical resection with a curative intent and numerous advances in the effectiveness of (neo)adjuvant therapies, metastatic disease remains ...
    • Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer. 

      Koundouros, N; Poulogiannis, G (2018-01)
      Metabolic rewiring and the consequent production of reactive oxygen species (ROS) are necessary to promote tumorigenesis. At the nexus of these cellular processes is the aberrant regulation of oncogenic signaling cascades ...
    • Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). 

      Mardakheh, FK; Sailem, HZ; Kümper, S; Tape, CJ; McCully, RR; Paul, A; Anjomani-Virmouni, S; Jørgensen, C; Poulogiannis, G; Marshall, CJ; Bakal, C (2016-12)
      Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation ...
    • Reprogramming of fatty acid metabolism in cancer. 

      Koundouros, N; Poulogiannis, G (2020-01)
      A common feature of cancer cells is their ability to rewire their metabolism to sustain the production of ATP and macromolecules needed for cell growth, division and survival. In particular, the importance of altered fatty ...