dc.contributor.author | Jiang, X | |
dc.contributor.author | Finucane, HK | |
dc.contributor.author | Schumacher, FR | |
dc.contributor.author | Schmit, SL | |
dc.contributor.author | Tyrer, JP | |
dc.contributor.author | Han, Y | |
dc.contributor.author | Michailidou, K | |
dc.contributor.author | Lesseur, C | |
dc.contributor.author | Kuchenbaecker, KB | |
dc.contributor.author | Dennis, J | |
dc.contributor.author | Conti, DV | |
dc.contributor.author | Casey, G | |
dc.contributor.author | Gaudet, MM | |
dc.contributor.author | Huyghe, JR | |
dc.contributor.author | Albanes, D | |
dc.contributor.author | Aldrich, MC | |
dc.contributor.author | Andrew, AS | |
dc.contributor.author | Andrulis, IL | |
dc.contributor.author | Anton-Culver, H | |
dc.contributor.author | Antoniou, AC | |
dc.contributor.author | Antonenkova, NN | |
dc.contributor.author | Arnold, SM | |
dc.contributor.author | Aronson, KJ | |
dc.contributor.author | Arun, BK | |
dc.contributor.author | Bandera, EV | |
dc.contributor.author | Barkardottir, RB | |
dc.contributor.author | Barnes, DR | |
dc.contributor.author | Batra, J | |
dc.contributor.author | Beckmann, MW | |
dc.contributor.author | Benitez, J | |
dc.contributor.author | Benlloch, S | |
dc.contributor.author | Berchuck, A | |
dc.contributor.author | Berndt, SI | |
dc.contributor.author | Bickeböller, H | |
dc.contributor.author | Bien, SA | |
dc.contributor.author | Blomqvist, C | |
dc.contributor.author | Boccia, S | |
dc.contributor.author | Bogdanova, NV | |
dc.contributor.author | Bojesen, SE | |
dc.contributor.author | Bolla, MK | |
dc.contributor.author | Brauch, H | |
dc.contributor.author | Brenner, H | |
dc.contributor.author | Brenton, JD | |
dc.contributor.author | Brook, MN | |
dc.contributor.author | Brunet, J | |
dc.contributor.author | Brunnström, H | |
dc.contributor.author | Buchanan, DD | |
dc.contributor.author | Burwinkel, B | |
dc.contributor.author | Butzow, R | |
dc.contributor.author | Cadoni, G | |
dc.contributor.author | Caldés, T | |
dc.contributor.author | Caligo, MA | |
dc.contributor.author | Campbell, I | |
dc.contributor.author | Campbell, PT | |
dc.contributor.author | Cancel-Tassin, G | |
dc.contributor.author | Cannon-Albright, L | |
dc.contributor.author | Campa, D | |
dc.contributor.author | Caporaso, N | |
dc.contributor.author | Carvalho, AL | |
dc.contributor.author | Chan, AT | |
dc.contributor.author | Chang-Claude, J | |
dc.contributor.author | Chanock, SJ | |
dc.contributor.author | Chen, C | |
dc.contributor.author | Christiani, DC | |
dc.contributor.author | Claes, KBM | |
dc.contributor.author | Claessens, F | |
dc.contributor.author | Clements, J | |
dc.contributor.author | Collée, JM | |
dc.contributor.author | Correa, MC | |
dc.contributor.author | Couch, FJ | |
dc.contributor.author | Cox, A | |
dc.contributor.author | Cunningham, JM | |
dc.contributor.author | Cybulski, C | |
dc.contributor.author | Czene, K | |
dc.contributor.author | Daly, MB | |
dc.contributor.author | deFazio, A | |
dc.contributor.author | Devilee, P | |
dc.contributor.author | Diez, O | |
dc.contributor.author | Gago-Dominguez, M | |
dc.contributor.author | Donovan, JL | |
dc.contributor.author | Dörk, T | |
dc.contributor.author | Duell, EJ | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Dwek, M | |
dc.contributor.author | Eccles, DM | |
dc.contributor.author | Edlund, CK | |
dc.contributor.author | Edwards, DRV | |
dc.contributor.author | Ellberg, C | |
dc.contributor.author | Evans, DG | |
dc.contributor.author | Fasching, PA | |
dc.contributor.author | Ferris, RL | |
dc.contributor.author | Liloglou, T | |
dc.contributor.author | Figueiredo, JC | |
dc.contributor.author | Fletcher, O | |
dc.contributor.author | Fortner, RT | |
dc.contributor.author | Fostira, F | |
dc.contributor.author | Franceschi, S | |
dc.contributor.author | Friedman, E | |
dc.contributor.author | Gallinger, SJ | |
dc.contributor.author | Ganz, PA | |
dc.contributor.author | Garber, J | |
dc.contributor.author | García-Sáenz, JA | |
dc.contributor.author | Gayther, SA | |
dc.contributor.author | Giles, GG | |
dc.contributor.author | Godwin, AK | |
dc.contributor.author | Goldberg, MS | |
dc.contributor.author | Goldgar, DE | |
dc.contributor.author | Goode, EL | |
dc.contributor.author | Goodman, MT | |
dc.contributor.author | Goodman, G | |
dc.contributor.author | Grankvist, K | |
dc.contributor.author | Greene, MH | |
dc.contributor.author | Gronberg, H | |
dc.contributor.author | Gronwald, J | |
dc.contributor.author | Guénel, P | |
dc.contributor.author | Håkansson, N | |
dc.contributor.author | Hall, P | |
dc.contributor.author | Hamann, U | |
dc.contributor.author | Hamdy, FC | |
dc.contributor.author | Hamilton, RJ | |
dc.contributor.author | Hampe, J | |
dc.contributor.author | Haugen, A | |
dc.contributor.author | Heitz, F | |
dc.contributor.author | Herrero, R | |
dc.contributor.author | Hillemanns, P | |
dc.contributor.author | Hoffmeister, M | |
dc.contributor.author | Høgdall, E | |
dc.contributor.author | Hong, Y-C | |
dc.contributor.author | Hopper, JL | |
dc.contributor.author | Houlston, R | |
dc.contributor.author | Hulick, PJ | |
dc.contributor.author | Hunter, DJ | |
dc.contributor.author | Huntsman, DG | |
dc.contributor.author | Idos, G | |
dc.contributor.author | Imyanitov, EN | |
dc.contributor.author | Ingles, SA | |
dc.contributor.author | Isaacs, C | |
dc.contributor.author | Jakubowska, A | |
dc.contributor.author | James, P | |
dc.contributor.author | Jenkins, MA | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | Johansson, M | |
dc.contributor.author | John, EM | |
dc.contributor.author | Joshi, AD | |
dc.contributor.author | Kaneva, R | |
dc.contributor.author | Karlan, BY | |
dc.contributor.author | Kelemen, LE | |
dc.contributor.author | Kühl, T | |
dc.contributor.author | Khaw, K-T | |
dc.contributor.author | Khusnutdinova, E | |
dc.contributor.author | Kibel, AS | |
dc.contributor.author | Kiemeney, LA | |
dc.contributor.author | Kim, J | |
dc.contributor.author | Kjaer, SK | |
dc.contributor.author | Knight, JA | |
dc.contributor.author | Kogevinas, M | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Koutros, S | |
dc.contributor.author | Kristensen, VN | |
dc.contributor.author | Kupryjanczyk, J | |
dc.contributor.author | Lacko, M | |
dc.contributor.author | Lam, S | |
dc.contributor.author | Lambrechts, D | |
dc.contributor.author | Landi, MT | |
dc.contributor.author | Lazarus, P | |
dc.contributor.author | Le, ND | |
dc.contributor.author | Lee, E | |
dc.contributor.author | Lejbkowicz, F | |
dc.contributor.author | Lenz, H-J | |
dc.contributor.author | Leslie, G | |
dc.contributor.author | Lessel, D | |
dc.contributor.author | Lester, J | |
dc.contributor.author | Levine, DA | |
dc.contributor.author | Li, L | |
dc.contributor.author | Li, CI | |
dc.contributor.author | Lindblom, A | |
dc.contributor.author | Lindor, NM | |
dc.contributor.author | Liu, G | |
dc.contributor.author | Loupakis, F | |
dc.contributor.author | Lubiński, J | |
dc.contributor.author | Maehle, L | |
dc.contributor.author | Maier, C | |
dc.contributor.author | Mannermaa, A | |
dc.contributor.author | Marchand, LL | |
dc.contributor.author | Margolin, S | |
dc.contributor.author | May, T | |
dc.contributor.author | McGuffog, L | |
dc.contributor.author | Meindl, A | |
dc.contributor.author | Middha, P | |
dc.contributor.author | Miller, A | |
dc.contributor.author | Milne, RL | |
dc.contributor.author | MacInnis, RJ | |
dc.contributor.author | Modugno, F | |
dc.contributor.author | Montagna, M | |
dc.contributor.author | Moreno, V | |
dc.contributor.author | Moysich, KB | |
dc.contributor.author | Mucci, L | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Mulligan, AM | |
dc.contributor.author | Nathanson, KL | |
dc.contributor.author | Neal, DE | |
dc.contributor.author | Ness, AR | |
dc.contributor.author | Neuhausen, SL | |
dc.contributor.author | Nevanlinna, H | |
dc.contributor.author | Newcomb, PA | |
dc.contributor.author | Newcomb, LF | |
dc.contributor.author | Nielsen, FC | |
dc.contributor.author | Nikitina-Zake, L | |
dc.contributor.author | Nordestgaard, BG | |
dc.contributor.author | Nussbaum, RL | |
dc.contributor.author | Offit, K | |
dc.contributor.author | Olah, E | |
dc.contributor.author | Olama, AAA | |
dc.contributor.author | Olopade, OI | |
dc.contributor.author | Olshan, AF | |
dc.contributor.author | Olsson, H | |
dc.contributor.author | Osorio, A | |
dc.contributor.author | Pandha, H | |
dc.contributor.author | Park, JY | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Parsons, MT | |
dc.contributor.author | Pejovic, T | |
dc.contributor.author | Penney, KL | |
dc.contributor.author | Peters, WHM | |
dc.contributor.author | Phelan, CM | |
dc.contributor.author | Phipps, AI | |
dc.contributor.author | Plaseska-Karanfilska, D | |
dc.contributor.author | Pring, M | |
dc.contributor.author | Prokofyeva, D | |
dc.contributor.author | Radice, P | |
dc.contributor.author | Stefansson, K | |
dc.contributor.author | Ramus, SJ | |
dc.contributor.author | Raskin, L | |
dc.contributor.author | Rennert, G | |
dc.contributor.author | Rennert, HS | |
dc.contributor.author | van Rensburg, EJ | |
dc.contributor.author | Riggan, MJ | |
dc.contributor.author | Risch, HA | |
dc.contributor.author | Risch, A | |
dc.contributor.author | Roobol, MJ | |
dc.contributor.author | Rosenstein, BS | |
dc.contributor.author | Rossing, MA | |
dc.contributor.author | De Ruyck, K | |
dc.contributor.author | Saloustros, E | |
dc.contributor.author | Sandler, DP | |
dc.contributor.author | Sawyer, EJ | |
dc.contributor.author | Schabath, MB | |
dc.contributor.author | Schleutker, J | |
dc.contributor.author | Schmidt, MK | |
dc.contributor.author | Setiawan, VW | |
dc.contributor.author | Shen, H | |
dc.contributor.author | Siegel, EM | |
dc.contributor.author | Sieh, W | |
dc.contributor.author | Singer, CF | |
dc.contributor.author | Slattery, ML | |
dc.contributor.author | Sorensen, KD | |
dc.contributor.author | Southey, MC | |
dc.contributor.author | Spurdle, AB | |
dc.contributor.author | Stanford, JL | |
dc.contributor.author | Stevens, VL | |
dc.contributor.author | Stintzing, S | |
dc.contributor.author | Stone, J | |
dc.contributor.author | Sundfeldt, K | |
dc.contributor.author | Sutphen, R | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Tajara, EH | |
dc.contributor.author | Tangen, CM | |
dc.contributor.author | Tardon, A | |
dc.contributor.author | Taylor, JA | |
dc.contributor.author | Teare, MD | |
dc.contributor.author | Teixeira, MR | |
dc.contributor.author | Terry, MB | |
dc.contributor.author | Terry, KL | |
dc.contributor.author | Thibodeau, SN | |
dc.contributor.author | Thomassen, M | |
dc.contributor.author | Bjørge, L | |
dc.contributor.author | Tischkowitz, M | |
dc.contributor.author | Toland, AE | |
dc.contributor.author | Torres, D | |
dc.contributor.author | Townsend, PA | |
dc.contributor.author | Travis, RC | |
dc.contributor.author | Tung, N | |
dc.contributor.author | Tworoger, SS | |
dc.contributor.author | Ulrich, CM | |
dc.contributor.author | Usmani, N | |
dc.contributor.author | Vachon, CM | |
dc.contributor.author | Van Nieuwenhuysen, E | |
dc.contributor.author | Vega, A | |
dc.contributor.author | Aguado-Barrera, ME | |
dc.contributor.author | Wang, Q | |
dc.contributor.author | Webb, PM | |
dc.contributor.author | Weinberg, CR | |
dc.contributor.author | Weinstein, S | |
dc.contributor.author | Weissler, MC | |
dc.contributor.author | Weitzel, JN | |
dc.contributor.author | West, CML | |
dc.contributor.author | White, E | |
dc.contributor.author | Whittemore, AS | |
dc.contributor.author | Wichmann, H-E | |
dc.contributor.author | Wiklund, F | |
dc.contributor.author | Winqvist, R | |
dc.contributor.author | Wolk, A | |
dc.contributor.author | Woll, P | |
dc.contributor.author | Woods, M | |
dc.contributor.author | Wu, AH | |
dc.contributor.author | Wu, X | |
dc.contributor.author | Yannoukakos, D | |
dc.contributor.author | Zheng, W | |
dc.contributor.author | Zienolddiny, S | |
dc.contributor.author | Ziogas, A | |
dc.contributor.author | Zorn, KK | |
dc.contributor.author | Lane, JM | |
dc.contributor.author | Saxena, R | |
dc.contributor.author | Thomas, D | |
dc.contributor.author | Hung, RJ | |
dc.contributor.author | Diergaarde, B | |
dc.contributor.author | McKay, J | |
dc.contributor.author | Peters, U | |
dc.contributor.author | Hsu, L | |
dc.contributor.author | García-Closas, M | |
dc.contributor.author | Eeles, RA | |
dc.contributor.author | Chenevix-Trench, G | |
dc.contributor.author | Brennan, PJ | |
dc.contributor.author | Haiman, CA | |
dc.contributor.author | Simard, J | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Gruber, SB | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Price, AL | |
dc.contributor.author | Pasaniuc, B | |
dc.contributor.author | Amos, CI | |
dc.contributor.author | Kraft, P | |
dc.contributor.author | Lindström, S | |
dc.date.accessioned | 2019-01-29T12:42:08Z | |
dc.date.issued | 2019-01-25 | |
dc.identifier.citation | Nature communications, 2019, 10 (1), pp. 431 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3032 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-018-08054-4 | |
dc.description.abstract | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. | |
dc.format | Electronic | |
dc.format.extent | 431 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PORTFOLIO | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Humans | |
dc.subject | Breast Neoplasms | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Ovarian Neoplasms | |
dc.subject | Head and Neck Neoplasms | |
dc.subject | Lung Neoplasms | |
dc.subject | Prostatic Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Neoplasm Proteins | |
dc.subject | Case-Control Studies | |
dc.subject | Smoking | |
dc.subject | Mental Disorders | |
dc.subject | Inheritance Patterns | |
dc.subject | Phenotype | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | European Continental Ancestry Group | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Genome-Wide Association Study | |
dc.title | Shared heritability and functional enrichment across six solid cancers. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-12-10 | |
rioxxterms.versionofrecord | 10.1038/s41467-018-08054-4 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2019-01-25 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 10 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Functional Genetic Epidemiology | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Brook, Mark | |
dc.contributor.icrauthor | Fletcher, Olivia | |
dc.contributor.icrauthor | Houlston, Richard | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Eeles, Rosalind | |