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dc.contributor.authorJiang, X
dc.contributor.authorFinucane, HK
dc.contributor.authorSchumacher, FR
dc.contributor.authorSchmit, SL
dc.contributor.authorTyrer, JP
dc.contributor.authorHan, Y
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dc.contributor.authorLesseur, C
dc.contributor.authorKuchenbaecker, KB
dc.contributor.authorDennis, J
dc.contributor.authorConti, DV
dc.contributor.authorCasey, G
dc.contributor.authorGaudet, MM
dc.contributor.authorHuyghe, JR
dc.contributor.authorAlbanes, D
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dc.contributor.authorAndrew, AS
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dc.contributor.authorAnton-Culver, H
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dc.contributor.authorAntonenkova, NN
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dc.contributor.authorArun, BK
dc.contributor.authorBandera, EV
dc.contributor.authorBarkardottir, RB
dc.contributor.authorBarnes, DR
dc.contributor.authorBatra, J
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dc.contributor.authorBenlloch, S
dc.contributor.authorBerchuck, A
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dc.contributor.authorBien, SA
dc.contributor.authorBlomqvist, C
dc.contributor.authorBoccia, S
dc.contributor.authorBogdanova, NV
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dc.contributor.authorBrook, MN
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dc.contributor.authorBrunnström, H
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dc.contributor.authorCadoni, G
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dc.contributor.authorCampbell, I
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dc.contributor.authorClaes, KBM
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dc.contributor.authorGodwin, AK
dc.contributor.authorGoldberg, MS
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dc.contributor.authorGrankvist, K
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dc.contributor.authorKhusnutdinova, E
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dc.contributor.authorKiemeney, LA
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dc.contributor.authorKristensen, VN
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dc.contributor.authorMaehle, L
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dc.contributor.authorMiller, A
dc.contributor.authorMilne, RL
dc.contributor.authorMacInnis, RJ
dc.contributor.authorModugno, F
dc.contributor.authorMontagna, M
dc.contributor.authorMoreno, V
dc.contributor.authorMoysich, KB
dc.contributor.authorMucci, L
dc.contributor.authorMuir, K
dc.contributor.authorMulligan, AM
dc.contributor.authorNathanson, KL
dc.contributor.authorNeal, DE
dc.contributor.authorNess, AR
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
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dc.contributor.authorNordestgaard, BG
dc.contributor.authorNussbaum, RL
dc.contributor.authorOffit, K
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dc.contributor.authorOsorio, A
dc.contributor.authorPandha, H
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dc.contributor.authorPashayan, N
dc.contributor.authorParsons, MT
dc.contributor.authorPejovic, T
dc.contributor.authorPenney, KL
dc.contributor.authorPeters, WHM
dc.contributor.authorPhelan, CM
dc.contributor.authorPhipps, AI
dc.contributor.authorPlaseska-Karanfilska, D
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dc.contributor.authorProkofyeva, D
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dc.contributor.authorStefansson, K
dc.contributor.authorRamus, SJ
dc.contributor.authorRaskin, L
dc.contributor.authorRennert, G
dc.contributor.authorRennert, HS
dc.contributor.authorvan Rensburg, EJ
dc.contributor.authorRiggan, MJ
dc.contributor.authorRisch, HA
dc.contributor.authorRisch, A
dc.contributor.authorRoobol, MJ
dc.contributor.authorRosenstein, BS
dc.contributor.authorRossing, MA
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dc.contributor.authorTischkowitz, M
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dc.contributor.authorTownsend, PA
dc.contributor.authorTravis, RC
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dc.contributor.authorTworoger, SS
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dc.contributor.authorVan Nieuwenhuysen, E
dc.contributor.authorVega, A
dc.contributor.authorAguado-Barrera, ME
dc.contributor.authorWang, Q
dc.contributor.authorWebb, PM
dc.contributor.authorWeinberg, CR
dc.contributor.authorWeinstein, S
dc.contributor.authorWeissler, MC
dc.contributor.authorWeitzel, JN
dc.contributor.authorWest, CML
dc.contributor.authorWhite, E
dc.contributor.authorWhittemore, AS
dc.contributor.authorWichmann, H-E
dc.contributor.authorWiklund, F
dc.contributor.authorWinqvist, R
dc.contributor.authorWolk, A
dc.contributor.authorWoll, P
dc.contributor.authorWoods, M
dc.contributor.authorWu, AH
dc.contributor.authorWu, X
dc.contributor.authorYannoukakos, D
dc.contributor.authorZheng, W
dc.contributor.authorZienolddiny, S
dc.contributor.authorZiogas, A
dc.contributor.authorZorn, KK
dc.contributor.authorLane, JM
dc.contributor.authorSaxena, R
dc.contributor.authorThomas, D
dc.contributor.authorHung, RJ
dc.contributor.authorDiergaarde, B
dc.contributor.authorMcKay, J
dc.contributor.authorPeters, U
dc.contributor.authorHsu, L
dc.contributor.authorGarcía-Closas, M
dc.contributor.authorEeles, RA
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorBrennan, PJ
dc.contributor.authorHaiman, CA
dc.contributor.authorSimard, J
dc.contributor.authorEaston, DF
dc.contributor.authorGruber, SB
dc.contributor.authorPharoah, PDP
dc.contributor.authorPrice, AL
dc.contributor.authorPasaniuc, B
dc.contributor.authorAmos, CI
dc.contributor.authorKraft, P
dc.contributor.authorLindström, S
dc.date.accessioned2019-01-29T12:42:08Z
dc.date.issued2019-01-25
dc.identifier.citationNature communications, 2019, 10 (1), pp. 431 - ?
dc.identifier.issn2041-1723
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3032
dc.identifier.eissn2041-1723
dc.identifier.doi10.1038/s41467-018-08054-4
dc.description.abstractQuantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r g  = 0.57, p = 4.6 × 10 -8 ), breast and ovarian cancer (r g  = 0.24, p = 7 × 10 -5 ), breast and lung cancer (r g  = 0.18, p =1.5 × 10 -6 ) and breast and colorectal cancer (r g  = 0.15, p = 1.1 × 10 -4 ). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
dc.formatElectronic
dc.format.extent431 - ?
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectColorectal Neoplasms
dc.subjectOvarian Neoplasms
dc.subjectHead and Neck Neoplasms
dc.subjectLung Neoplasms
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectNeoplasm Proteins
dc.subjectCase-Control Studies
dc.subjectSmoking
dc.subjectMental Disorders
dc.subjectInheritance Patterns
dc.subjectPhenotype
dc.subjectPolymorphism, Single Nucleotide
dc.subjectEuropean Continental Ancestry Group
dc.subjectFemale
dc.subjectMale
dc.subjectGenome-Wide Association Study
dc.titleShared heritability and functional enrichment across six solid cancers.
dc.typeJournal Article
dcterms.dateAccepted2018-12-10
rioxxterms.versionofrecord10.1038/s41467-018-08054-4
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0
rioxxterms.licenseref.startdate2019-01-25
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature communications
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Functional Genetic Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume10
pubs.embargo.termsNot known
icr.researchteamFunctional Genetic Epidemiologyen_US
icr.researchteamAetiological Epidemiologyen_US
icr.researchteamCancer Genomicsen_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorFletcher, Oliviaen
dc.contributor.icrauthorSwerdlow, Anthonyen
dc.contributor.icrauthorBrook, Marken
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorEeles, Rosalinden


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