dc.contributor.author | Mardakheh, FK | |
dc.contributor.author | Sailem, HZ | |
dc.contributor.author | Kümper, S | |
dc.contributor.author | Tape, CJ | |
dc.contributor.author | McCully, RR | |
dc.contributor.author | Paul, A | |
dc.contributor.author | Anjomani-Virmouni, S | |
dc.contributor.author | Jørgensen, C | |
dc.contributor.author | Poulogiannis, G | |
dc.contributor.author | Marshall, CJ | |
dc.contributor.author | Bakal, C | |
dc.date.accessioned | 2016-11-25T09:58:56Z | |
dc.date.issued | 2016-12-20 | |
dc.identifier.citation | Molecular bioSystems, 2016, 13 (1), pp. 92 - 105 | |
dc.identifier.issn | 1742-206X | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/307 | |
dc.identifier.eissn | 1742-2051 | |
dc.identifier.doi | 10.1039/c6mb00701e | |
dc.description.abstract | Localisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation of two proteins can therefore be indicative of their functional association. We here present COLA, a proteomics based strategy coupled with a bioinformatics framework to detect protein-protein co-localisations on a global scale. COLA reveals functional interactions by matching proteins with significant similarity in their subcellular localisation signatures. The rapid nature of COLA allows mapping of interactome dynamics across different conditions or treatments with high precision. | |
dc.format | Print | |
dc.format.extent | 92 - 105 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | ROYAL SOC CHEMISTRY | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
dc.subject | Cell Line | |
dc.subject | Intracellular Space | |
dc.subject | Subcellular Fractions | |
dc.subject | Humans | |
dc.subject | Proteome | |
dc.subject | Chromatography, Liquid | |
dc.subject | Cell Fractionation | |
dc.subject | Cluster Analysis | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Protein Interaction Mapping | |
dc.subject | Proteomics | |
dc.subject | Protein Binding | |
dc.subject | Protein Transport | |
dc.subject | Mass Spectrometry | |
dc.subject | Protein Interaction Maps | |
dc.title | Proteomics profiling of interactome dynamics by colocalisation analysis (COLA). | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2016-11-01 | |
rioxxterms.versionofrecord | 10.1039/c6mb00701e | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2016-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Molecular bioSystems | |
pubs.issue | 1 | |
pubs.notes | No embargo | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Signalling & Cancer Metabolism | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Oncogene | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Cancer Biology/Signalling & Cancer Metabolism | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Closed research teams/Oncogene | |
pubs.publication-status | Published | |
pubs.volume | 13 | |
pubs.embargo.terms | No embargo | |
icr.researchteam | Dynamical Cell Systems | |
icr.researchteam | Signalling & Cancer Metabolism | |
icr.researchteam | Oncogene | |
dc.contributor.icrauthor | Poulogiannis, Georgios | |
dc.contributor.icrauthor | Bakal, Christopher | |