Show simple item record

dc.contributor.authorMardakheh, FKen_US
dc.contributor.authorSailem, HZen_US
dc.contributor.authorKümper, Sen_US
dc.contributor.authorTape, CJen_US
dc.contributor.authorMcCully, RRen_US
dc.contributor.authorPaul, Aen_US
dc.contributor.authorAnjomani-Virmouni, Sen_US
dc.contributor.authorJørgensen, Cen_US
dc.contributor.authorPoulogiannis, Gen_US
dc.contributor.authorMarshall, CJen_US
dc.contributor.authorBakal, Cen_US
dc.date.accessioned2016-11-25T09:58:56Z
dc.date.issued2016-12en_US
dc.identifier.citationMolecular bioSystems, 2016, 13 (1), pp. 92 - 105en_US
dc.identifier.issn1742-206Xen_US
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/307
dc.identifier.eissn1742-2051en_US
dc.identifier.doi10.1039/c6mb00701een_US
dc.description.abstractLocalisation and protein function are intimately linked in eukaryotes, as proteins are localised to specific compartments where they come into proximity of other functionally relevant proteins. Significant co-localisation of two proteins can therefore be indicative of their functional association. We here present COLA, a proteomics based strategy coupled with a bioinformatics framework to detect protein-protein co-localisations on a global scale. COLA reveals functional interactions by matching proteins with significant similarity in their subcellular localisation signatures. The rapid nature of COLA allows mapping of interactome dynamics across different conditions or treatments with high precision.en_US
dc.formatPrinten_US
dc.format.extent92 - 105en_US
dc.languageengen_US
dc.language.isoengen_US
dc.subjectCell Lineen_US
dc.subjectIntracellular Spaceen_US
dc.subjectSubcellular Fractionsen_US
dc.subjectHumansen_US
dc.subjectProteomeen_US
dc.subjectChromatography, Liquiden_US
dc.subjectCell Fractionationen_US
dc.subjectCluster Analysisen_US
dc.subjectSensitivity and Specificityen_US
dc.subjectProtein Interaction Mappingen_US
dc.subjectProteomicsen_US
dc.subjectProtein Bindingen_US
dc.subjectProtein Transporten_US
dc.subjectMass Spectrometryen_US
dc.subjectProtein Interaction Mapsen_US
dc.titleProteomics profiling of interactome dynamics by colocalisation analysis (COLA).en_US
dc.typeJournal Article
dcterms.dateAccepted2016-11-01en_US
rioxxterms.versionofrecord10.1039/c6mb00701een_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0en_US
rioxxterms.licenseref.startdate2016-12en_US
rioxxterms.typeJournal Article/Reviewen_US
dc.relation.isPartOfMolecular bioSystemsen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Dynamical Cell Systems
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Cancer Biology/Signalling & Cancer Metabolism
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Oncogene
pubs.publication-statusPublisheden_US
pubs.volume13en_US
pubs.embargo.termsNo embargoen_US
icr.researchteamDynamical Cell Systemsen_US
icr.researchteamSignalling & Cancer Metabolismen_US
icr.researchteamOncogeneen_US
dc.contributor.icrauthorTape, Christopheren_US
dc.contributor.icrauthorBakal, Christopheren_US
dc.contributor.icrauthorPoulogiannis, Georgiosen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record