dc.contributor.author | Lawler, M | |
dc.contributor.author | Alsina, D | |
dc.contributor.author | Adams, RA | |
dc.contributor.author | Anderson, AS | |
dc.contributor.author | Brown, G | |
dc.contributor.author | Fearnhead, NS | |
dc.contributor.author | Fenwick, SW | |
dc.contributor.author | Halloran, SP | |
dc.contributor.author | Hochhauser, D | |
dc.contributor.author | Hull, MA | |
dc.contributor.author | Koelzer, VH | |
dc.contributor.author | McNair, AGK | |
dc.contributor.author | Monahan, KJ | |
dc.contributor.author | Näthke, I | |
dc.contributor.author | Norton, C | |
dc.contributor.author | Novelli, MR | |
dc.contributor.author | Steele, RJC | |
dc.contributor.author | Thomas, AL | |
dc.contributor.author | Wilde, LM | |
dc.contributor.author | Wilson, RH | |
dc.contributor.author | Tomlinson, I | |
dc.contributor.author | Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative, | |
dc.date.accessioned | 2018-02-13T16:32:05Z | |
dc.date.accessioned | 2019-02-27T11:50:26Z | |
dc.date.issued | 2018-01-01 | |
dc.identifier.citation | Gut, 2018, 67 (1), pp. 179 - 193 | |
dc.identifier.issn | 0017-5749 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/3105 | |
dc.identifier.eissn | 1468-3288 | |
dc.identifier.doi | 10.1136/gutjnl-2017-315333 | |
dc.description.abstract | OBJECTIVE: Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. DESIGN: RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants. RESULTS: Fifteen critical RGs are summarised below: RG1: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; RG2: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; RG3: Pressing need for prevention trials; RG4: Lack of integration of different prevention approaches; RG5: Lack of optimal strategies for CRC screening; RG6: Lack of effective triage systems for invasive investigations; RG7: Imprecise pathological assessment of CRC; RG8: Lack of qualified personnel in genomics, data sciences and digital pathology; RG9: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; RG10: Need for novel technologies/interventions to improve curative outcomes; RG11: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; RG12: Lack of reliable biomarkers to guide stage IV treatment; RG13: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; RG14: Lack of coordination of CRC research/funding; RG15: Lack of effective communication between relevant stakeholders. CONCLUSION: Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years. | |
dc.format | Print | |
dc.format.extent | 179 - 193 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | BMJ PUBLISHING GROUP | |
dc.relation.replaces | https://repository.icr.ac.uk/handle/internal/1052 | |
dc.relation.replaces | internal/1052 | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | Bowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative | |
dc.subject | Humans | |
dc.subject | Colorectal Neoplasms | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Risk Factors | |
dc.subject | Evidence-Based Medicine | |
dc.subject | Biomedical Research | |
dc.subject | Early Detection of Cancer | |
dc.subject | Gene-Environment Interaction | |
dc.title | Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-10-25 | |
rioxxterms.versionofrecord | 10.1136/gutjnl-2017-315333 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc/4.0 | |
rioxxterms.licenseref.startdate | 2018-01 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Gut | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics | |
pubs.organisational-group | /ICR/Primary Group/Royal Marsden Clinical Units | |
pubs.publication-status | Published | |
pubs.volume | 67 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Translational Oncogenomics | |
dc.contributor.icrauthor | Marsden, | |
dc.contributor.icrauthor | Houlston, Richard | |
dc.contributor.icrauthor | Gerlinger, Marco | |