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dc.contributor.authorLawler, M
dc.contributor.authorAlsina, D
dc.contributor.authorAdams, RA
dc.contributor.authorAnderson, AS
dc.contributor.authorBrown, G
dc.contributor.authorFearnhead, NS
dc.contributor.authorFenwick, SW
dc.contributor.authorHalloran, SP
dc.contributor.authorHochhauser, D
dc.contributor.authorHull, MA
dc.contributor.authorKoelzer, VH
dc.contributor.authorMcNair, AGK
dc.contributor.authorMonahan, KJ
dc.contributor.authorNäthke, I
dc.contributor.authorNorton, C
dc.contributor.authorNovelli, MR
dc.contributor.authorSteele, RJC
dc.contributor.authorThomas, AL
dc.contributor.authorWilde, LM
dc.contributor.authorWilson, RH
dc.contributor.authorTomlinson, I
dc.contributor.authorBowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative
dc.date.accessioned2018-02-13T16:32:05Z
dc.date.accessioned2019-02-27T11:50:26Z
dc.date.issued2018-01
dc.identifier.citationGut, 2018, 67 (1), pp. 179 - 193
dc.identifier.issn0017-5749
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/3105
dc.identifier.eissn1468-3288
dc.identifier.doi10.1136/gutjnl-2017-315333
dc.description.abstractObjective Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes.Design RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working groups (WG) were constituted: discovery science; risk; prevention; early diagnosis and screening; pathology; curative treatment; stage IV disease; and living with and beyond CRC. A series of discussions led to development of draft papers by each WG, which were evaluated by a 20-strong patient panel. A final list of RGs and research recommendations (RR) was endorsed by all participants.Results Fifteen critical RGs are summarised below: <i>RG1</i>: Lack of realistic models that recapitulate tumour/tumour micro/macroenvironment; <i>RG2</i>: Insufficient evidence on precise contributions of genetic/environmental/lifestyle factors to CRC risk; <i>RG3</i>: Pressing need for prevention trials; <i>RG4</i>: Lack of integration of different prevention approaches; <i>RG5</i>: Lack of optimal strategies for CRC screening; <i>RG6</i>: Lack of effective triage systems for invasive investigations; <i>RG7</i>: Imprecise pathological assessment of CRC; <i>RG8</i>: Lack of qualified personnel in genomics, data sciences and digital pathology; <i>RG9</i>: Inadequate assessment/communication of risk, benefit and uncertainty of treatment choices; <i>RG10</i>: Need for novel technologies/interventions to improve curative outcomes; <i>RG11</i>: Lack of approaches that recognise molecular interplay between metastasising tumours and their microenvironment; <i>RG12</i>: Lack of reliable biomarkers to guide stage IV treatment; <i>RG13</i>: Need to increase understanding of health related quality of life (HRQOL) and promote residual symptom resolution; <i>RG14</i>: Lack of coordination of CRC research/funding; <i>RG15</i>: Lack of effective communication between relevant stakeholders.Conclusion Prioritising research activity and funding could have a significant impact on reducing CRC disease burden over the next 5 years.
dc.formatPrint
dc.format.extent179 - 193
dc.languageeng
dc.language.isoeng
dc.relation.replaceshttps://repository.icr.ac.uk/handle/internal/1052
dc.relation.replacesinternal/1052
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectBowel Cancer UK Critical Research Gaps in Colorectal Cancer Initiative
dc.subjectHumans
dc.subjectColorectal Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectRisk Factors
dc.subjectEvidence-Based Medicine
dc.subjectBiomedical Research
dc.subjectEarly Detection of Cancer
dc.subjectGene-Environment Interaction
dc.titleCritical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer.
dc.typeJournal Article
dcterms.dateAccepted2017-10-25
rioxxterms.versionofrecord10.1136/gutjnl-2017-315333
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc/4.0
rioxxterms.licenseref.startdate2018-01
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfGut
pubs.issue1
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Molecular Pathology/Translational Oncogenomics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume67en_US
pubs.embargo.termsNot known
icr.researchteamCancer Genomicsen_US
icr.researchteamTranslational Oncogenomicsen_US
dc.contributor.icrauthorMarsden,en
dc.contributor.icrauthorHoulston, Richarden
dc.contributor.icrauthorGerlinger, Marcoen


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