Prediction of chemotherapy benefit by EndoPredict in patients with breast cancer who received adjuvant endocrine therapy plus chemotherapy or endocrine therapy alone.
View/ Open
Date
2019-07-01ICR Author
Author
Sestak, I
Martín, M
Dubsky, P
Kronenwett, R
Rojo, F
Cuzick, J
Filipits, M
Ruiz, A
Gradishar, W
Soliman, H
Schwartzberg, L
Buus, R
Hlauschek, D
Rodríguez-Lescure, A
Gnant, M
Type
Journal Article
Metadata
Show full item recordAbstract
PURPOSE: EndoPredict (EPclin) is a prognostic test validated to inform decisions on adjuvant chemotherapy to endocrine therapy alone for patients with oestrogen receptor-positive, HER2-negative breast cancer. Here, we determine the performance of EPclin for estimating 10-year distant recurrence-free interval (DRFI) rates for those who received adjuvant endocrine therapy (ET) alone compared to those with chemotherapy plus endocrine therapy (ET + C). METHODS: A total of 3746 women were included in this joint analysis. 2630 patients received 5 years of ET alone (ABCSG-6/8, TransATAC) and 1116 patients received ET + C (GEICAM 2003-02/9906). The primary objective was to evaluate the ability of EPclin to provide an estimate of the 10-year DR rate as a continuous function of EPclin separately for ET alone and ET + C. Cox proportional hazard models were used for these analyses. RESULTS: EPclin was highly prognostic for DR in women who received ET alone (HR 2.79 (2.49-3.13), P < 0.0001) as well as in those who received ET + C (HR 2.27 (1.99-2.59), P < 0.0001). Women who received ET + C had significantly smaller increases in 10-year DR rates with the increasing EPclin score than those receiving ET alone (EPclin = 5; 12% ET + C vs. 20% ET alone). We observed a significant positive interaction between EPclin and treatment groups (P-interaction = 0.022). CONCLUSIONS: In this comparative non-randomised analysis, the rate of increase in DR with EPclin score was significantly reduced in women who received ET + C versus ET alone. Our indirect comparisons suggest that a high EPclin score can predict chemotherapy benefit in women with ER-positive, HER2-negative disease.
Collections
Subject
Humans
Breast Neoplasms
Cyclophosphamide
Fluorouracil
Doxorubicin
Receptor, erbB-2
Receptors, Estrogen
Antineoplastic Agents, Hormonal
Antineoplastic Combined Chemotherapy Protocols
Prognosis
Treatment Outcome
Combined Modality Therapy
Chemotherapy, Adjuvant
Proportional Hazards Models
Risk Assessment
Retrospective Studies
Predictive Value of Tests
Aged
Middle Aged
Female
Clinical Trials as Topic
Kaplan-Meier Estimate
Language
eng
Date accepted
2019-04-08
License start date
2019-07
Citation
Breast cancer research and treatment, 2019, 176 (2), pp. 377 - 386
Publisher
SPRINGER