GENCODE reference annotation for the human and mouse genomes.
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Date
2019-01-08Author
Frankish, A
Diekhans, M
Ferreira, A-M
Johnson, R
Jungreis, I
Loveland, J
Mudge, JM
Sisu, C
Wright, J
Armstrong, J
Barnes, I
Berry, A
Bignell, A
Carbonell Sala, S
Chrast, J
Cunningham, F
Di Domenico, T
Donaldson, S
Fiddes, IT
García Girón, C
Gonzalez, JM
Grego, T
Hardy, M
Hourlier, T
Hunt, T
Izuogu, OG
Lagarde, J
Martin, FJ
Martínez, L
Mohanan, S
Muir, P
Navarro, FCP
Parker, A
Pei, B
Pozo, F
Ruffier, M
Schmitt, BM
Stapleton, E
Suner, M-M
Sycheva, I
Uszczynska-Ratajczak, B
Xu, J
Yates, A
Zerbino, D
Zhang, Y
Aken, B
Choudhary, JS
Gerstein, M
Guigó, R
Hubbard, TJP
Kellis, M
Paten, B
Reymond, A
Tress, ML
Flicek, P
Type
Journal Article
Metadata
Show full item recordAbstract
The accurate identification and description of the genes in the human and mouse genomes is a fundamental requirement for high quality analysis of data informing both genome biology and clinical genomics. Over the last 15 years, the GENCODE consortium has been producing reference quality gene annotations to provide this foundational resource. The GENCODE consortium includes both experimental and computational biology groups who work together to improve and extend the GENCODE gene annotation. Specifically, we generate primary data, create bioinformatics tools and provide analysis to support the work of expert manual gene annotators and automated gene annotation pipelines. In addition, manual and computational annotation workflows use any and all publicly available data and analysis, along with the research literature to identify and characterise gene loci to the highest standard. GENCODE gene annotations are accessible via the Ensembl and UCSC Genome Browsers, the Ensembl FTP site, Ensembl Biomart, Ensembl Perl and REST APIs as well as https://www.gencodegenes.org.
Collections
Subject
Animals
Humans
Mice
Computational Biology
Genomics
Pseudogenes
Genome, Human
Internet
Software
Databases, Genetic
Molecular Sequence Annotation
Research team
Functional Proteomics Group
Language
eng
Date accepted
2018-10-08
License start date
2019-01
Citation
Nucleic acids research, 2019, 47 (D1), pp. D766 - D773
Publisher
OXFORD UNIV PRESS