Nipple-sparing mastectomy in women at high risk of developing breast cancer.
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Nipple-sparing mastectomy is a valuable addition to the options available for women at high risk of developing breast cancer. In this review, we summarize current knowledge about the high-risk genes, <i>BRCA1</i>, <i>BRCA2</i> and <i>TP53</i> and the associated guidelines with regard to risk-reducing surgery. We consider other genetic risks and high-risk lesions. We discuss the literature on bilateral mastectomy for breast cancer risk-reduction, and the results of nipple-sparing mastectomy in particular. Finally, we report on patient satisfaction with these procedures and the impact that nipple-sparing mastectomy may have on women at high-risk of breast cancer.
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Gland surgery, 2018, 7 (3), pp. 325 - 336