Measuring cancer evolution from the genome.
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Date
2017-01-01Author
Graham, TA
Sottoriva, A
Type
Journal Article
Metadata
Show full item recordAbstract
The temporal dynamics of cancer evolution remain elusive, because it is impractical to longitudinally observe cancers unperturbed by treatment. Consequently, our knowledge of how cancers grow largely derives from inferences made from a single point in time - the endpoint in the cancer's evolution, when it is removed from the body and studied in the laboratory. Fortuitously however, the cancer genome, by virtue of ongoing mutations that uniquely mark clonal lineages within the tumour, provides a rich, yet surreptitious, record of cancer development. In this review, we describe how a cancer's genome can be analysed to reveal the temporal history of mutation and selection, and discuss why both selective and neutral evolution feature prominently in carcinogenesis. We argue that selection in cancer can only be properly studied once we have some understanding of what the absence of selection looks like. We review the data describing punctuated evolution in cancer, and reason that punctuated phenotype evolution is consistent with both gradual and punctuated genome evolution. We conclude that, to map and predict evolutionary trajectories during carcinogenesis, it is critical to better understand the relationship between genotype change and phenotype change. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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Subject
Animals
Humans
Neoplasms
Genetic Predisposition to Disease
Genotype
Phenotype
Genetic Testing
Biological Evolution
Language
eng
Date accepted
2016-10-07
License start date
2017-01
Citation
The Journal of pathology, 2017, 241 (2), pp. 183 - 191
Publisher
WILEY-BLACKWELL