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The transformation of radiation oncology using real-time magnetic resonance guidance: A review.

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ICR Author
Harrington, Kevin
Author
Hall, WA
Paulson, ES
van der Heide, UA
Fuller, CD
Raaymakers, BW
Lagendijk, JJW
Li, XA
Jaffray, DA
Dawson, LA
Erickson, B
Verheij, M
Harrington, KJ
Sahgal, A
Lee, P
Parikh, PJ
Bassetti, MF
Robinson, CG
Minsky, BD
Choudhury, A
Tersteeg, RJHA
Schultz, CJ
MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium
Type
Journal Article
Metadata
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Abstract
Radiation therapy (RT) is an essential component of effective cancer care and is used across nearly all cancer types. The delivery of RT is becoming more precise through rapid advances in both computing and imaging. The direct integration of magnetic resonance imaging (MRI) with linear accelerators represents an exciting development with the potential to dramatically impact cancer research and treatment. These impacts extend beyond improved imaging and dose deposition. Real-time MRI-guided RT is actively transforming the work flows and capabilities of virtually every aspect of RT. It has the opportunity to change entirely the delivery methods and response assessments of numerous malignancies. This review intends to approach the topic of MRI-based RT guidance from a vendor neutral and international perspective. It also aims to provide an introduction to this topic targeted towards oncologists without a speciality focus in RT. Speciality implications, areas for physician education and research opportunities are identified as they are associated with MRI-guided RT. The uniquely disruptive implications of MRI-guided RT are discussed and placed in context. We further aim to describe and outline important future changes to the speciality of radiation oncology that will occur with MRI-guided RT. The impacts on RT caused by MRI guidance include target identification, RT planning, quality assurance, treatment delivery, training, clinical workflow, tumour response assessment and treatment scheduling. In addition, entirely novel research areas that may be enabled by MRI guidance are identified for future investigation.
URL
https://repository.icr.ac.uk/handle/internal/4446
Collections
  • Cancer Biology
  • Radiotherapy and Imaging
Licenseref URL
http://www.rioxx.net/licenses/all-rights-reserved
Version
AM
Version of record
10.1016/j.ejca.2019.07.021
Subject
MR Linac Atlantic Consortium and the ViewRay C2T2 Research Consortium
Humans
Magnetic Resonance Imaging
Radiation Oncology
Quality Assurance, Health Care
Radiotherapy, Image-Guided
Research team
Targeted Therapy
Language
eng
Date accepted
2019-07-16
Citation
European journal of cancer (Oxford, England : 1990), 2019, 122 pp. 42 - 52

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