Landscape of transcriptomic interactions between breast cancer and its microenvironment.
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Date
2019-07-15ICR Author
Author
Fox, NS
Haider, S
Harris, AL
Boutros, PC
Type
Journal Article
Metadata
Show full item recordAbstract
Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour's microenvironment. Despite this complexity, clinical genomic profiling is typically performed from bulk samples, without distinguishing TCs from TACs. To better understand TC-TAC interactions, we computationally distinguish their transcriptomes in 1780 primary breast tumours. We show that TC and TAC mRNA abundances are divergently associated with clinical phenotypes, including tumour subtypes and patient survival. These differences reflect distinct responses of TCs and TACs to specific somatic driver mutations, particularly TP53. These data further elucidate how the molecular interplay between breast tumours and their microenvironment drives aggressive tumour phenotypes.
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Subject
Humans
Breast Neoplasms
RNA, Messenger
Prognosis
Gene Expression Profiling
Female
Tumor Microenvironment
Biomarkers, Tumor
Clinical Decision-Making
Language
eng
Date accepted
2019-06-04
License start date
2019-07-15
Citation
Nature communications, 2019, 10 (1), pp. 3116 - ?
Publisher
NATURE PUBLISHING GROUP