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dc.contributor.authorVandersluis, AD
dc.contributor.authorGuy, DE
dc.contributor.authorKlotz, LH
dc.contributor.authorFleshner, NE
dc.contributor.authorKiss, A
dc.contributor.authorParker, C
dc.contributor.authorVenkateswaran, V
dc.date.accessioned2017-03-02T16:55:31Z
dc.date.issued2016-09
dc.identifier.citationProstate cancer and prostatic diseases, 2016, 19 (3), pp. 305 - 310
dc.identifier.issn1365-7852
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/467
dc.identifier.eissn1476-5608
dc.identifier.doi10.1038/pcan.2016.22
dc.description.abstractBackground Although much research has examined the relationship between lifestyle and prostate cancer (PCa) risk, few studies focus on the relationship between lifestyle and PCa progression. The present study examines this relationship among men initially diagnosed with low- to intermediate-risk PCa and managed with active surveillance (AS).Methods Men enrolled in two separate AS programs were recruited for this study. Data regarding clinical, demographic and lifestyle characteristics were collected. Results were then compared between men whose disease remained low- to intermediate-risk and men whose disease progressed.Results Demographic, clinical and physical characteristics were similar between comparative groups and cohorts, with the exception that age at the time of diagnosis and questionnaire was increased among men whose disease progressed. Lifestyle scores among men who remained low- to intermediate-risk were higher than those whose risk progressed; however, scores were only significant in one cohort on univariable analysis. On multivariable analysis, the only predictor of progression was age at diagnosis. Physical activity was consistently higher in both low risk groups, although this difference was insignificant. Consistent differences in other lifestyle variables were not observed.Conclusions Age remains an important predictor of PCa progression. Improving lifestyle characteristics among men initially managed with AS might help to reduce the risk of progression. Given the limitations of this study, more rigorous investigation is required to confirm whether lifestyle characteristics influence the progression of low- to intermediate-risk PCa.
dc.formatPrint-Electronic
dc.format.extent305 - 310
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectDisease Progression
dc.subjectPrognosis
dc.subjectPopulation Surveillance
dc.subjectOdds Ratio
dc.subjectRisk Factors
dc.subjectCohort Studies
dc.subjectFeeding Behavior
dc.subjectLife Style
dc.subjectTime Factors
dc.subjectAdult
dc.subjectAged
dc.subjectAged, 80 and over
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectNeoplasm Grading
dc.subjectSurveys and Questionnaires
dc.titleThe role of lifestyle characteristics on prostate cancer progression in two active surveillance cohorts.
dc.typeJournal Article
dcterms.dateAccepted2016-05-17
rioxxterms.versionofrecord10.1038/pcan.2016.22
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-09
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfProstate cancer and prostatic diseases
pubs.issue3
pubs.notes6 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume19
pubs.embargo.terms6 months
dc.contributor.icrauthorParker, Chris


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