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The role of lifestyle characteristics on prostate cancer progression in two active surveillance cohorts.

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Date
2016-09
ICR Author
Parker, Chris
Author
Vandersluis, AD
Guy, DE
Klotz, LH
Fleshner, NE
Kiss, A
Parker, C
Venkateswaran, V
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Type
Journal Article
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Abstract
Background Although much research has examined the relationship between lifestyle and prostate cancer (PCa) risk, few studies focus on the relationship between lifestyle and PCa progression. The present study examines this relationship among men initially diagnosed with low- to intermediate-risk PCa and managed with active surveillance (AS).Methods Men enrolled in two separate AS programs were recruited for this study. Data regarding clinical, demographic and lifestyle characteristics were collected. Results were then compared between men whose disease remained low- to intermediate-risk and men whose disease progressed.Results Demographic, clinical and physical characteristics were similar between comparative groups and cohorts, with the exception that age at the time of diagnosis and questionnaire was increased among men whose disease progressed. Lifestyle scores among men who remained low- to intermediate-risk were higher than those whose risk progressed; however, scores were only significant in one cohort on univariable analysis. On multivariable analysis, the only predictor of progression was age at diagnosis. Physical activity was consistently higher in both low risk groups, although this difference was insignificant. Consistent differences in other lifestyle variables were not observed.Conclusions Age remains an important predictor of PCa progression. Improving lifestyle characteristics among men initially managed with AS might help to reduce the risk of progression. Given the limitations of this study, more rigorous investigation is required to confirm whether lifestyle characteristics influence the progression of low- to intermediate-risk PCa.
URI
https://repository.icr.ac.uk/handle/internal/467
DOI
https://doi.org/10.1038/pcan.2016.22
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Subject
Humans
Prostatic Neoplasms
Disease Progression
Prognosis
Population Surveillance
Odds Ratio
Risk Factors
Cohort Studies
Feeding Behavior
Life Style
Time Factors
Adult
Aged
Aged, 80 and over
Middle Aged
Male
Neoplasm Grading
Surveys and Questionnaires
Language
eng
Date accepted
2016-05-17
License start date
2016-09
Citation
Prostate cancer and prostatic diseases, 2016, 19 (3), pp. 305 - 310

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