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dc.contributor.authorMazzinari, G
dc.contributor.authorSerpa Neto, A
dc.contributor.authorHemmes, SNT
dc.contributor.authorHedenstierna, G
dc.contributor.authorJaber, S
dc.contributor.authorHiesmayr, M
dc.contributor.authorHollmann, MW
dc.contributor.authorMills, GH
dc.contributor.authorVidal Melo, MF
dc.contributor.authorPearse, RM
dc.contributor.authorPutensen, C
dc.contributor.authorSchmid, W
dc.contributor.authorSevergnini, P
dc.contributor.authorWrigge, H
dc.contributor.authorCambronero, OD
dc.contributor.authorBall, L
dc.contributor.authorde Abreu, MG
dc.contributor.authorPelosi, P
dc.contributor.authorSchultz, MJ
dc.contributor.authorLAS VEGAS study–investigators
dc.contributor.authorPROtective VEntilation NETwork
dc.contributor.authorClinical Trial Network of the European Society of Anaesthesiology
dc.date.accessioned2022-05-13T12:40:22Z
dc.date.available2022-05-13T12:40:22Z
dc.date.issued2021-03-19
dc.identifier.citationBMC anesthesiology, 2021, 21 (1), pp. 84 - ?en
dc.identifier.issn1471-2253
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/5124
dc.identifier.eissn1471-2253en_US
dc.identifier.eissn1471-2253
dc.identifier.doi10.1186/s12871-021-01268-yen_US
dc.identifier.doi10.1186/s12871-021-01268-y
dc.description.abstract<h4>Background</h4>It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time-weighted average ΔP (ΔP<sub>TW</sub>) with PPCs. We also tested the association of ΔP<sub>TW</sub> with intraoperative adverse events.<h4>Methods</h4>Posthoc retrospective propensity score-weighted cohort analysis of patients undergoing open or closed abdominal surgery in the 'Local ASsessment of Ventilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events.<h4>Results</h4>The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔP<sub>TW</sub> was not different between groups. The association of ΔP<sub>TW</sub> with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P <  0.001 versus 1.05 [95%CI 1.05 to 1.05], P <  0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P <  0.001). The association of ΔP<sub>TW</sub> with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12- to 1.14], P <  0.001 versus 1.07 [95%CI 1.05 to 1.10], P <  0.001; risk difference 0.05 [95%CI 0.030.07], P <  0.001).<h4>Conclusions</h4>ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery.<h4>Trial registration</h4>LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223 ).en_US
dc.formatElectronicen_US
dc.format.extent84 - ?en_US
dc.languageengen_US
dc.language.isoengen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectLAS VEGAS study–investigatorsen_US
dc.subjectPROtective VEntilation NETworken_US
dc.subjectClinical Trial Network of the European Society of Anaesthesiologyen_US
dc.subjectAbdomenen_US
dc.subjectHumansen_US
dc.subjectLung Diseasesen_US
dc.subjectPostoperative Complicationsen_US
dc.subjectLaparoscopyen_US
dc.subjectRespiration, Artificialen_US
dc.subjectPositive-Pressure Respirationen_US
dc.subjectAnesthesia, Generalen_US
dc.subjectRetrospective Studiesen_US
dc.subjectCohort Studiesen_US
dc.subjectAdulten_US
dc.subjectAgeden_US
dc.subjectMiddle Ageden_US
dc.subjectFemaleen_US
dc.subjectMaleen_US
dc.subjectPropensity Scoreen_US
dc.titleThe Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients - a posthoc propensity score-weighted cohort analysis of the LAS VEGAS study.en
dc.typeJournal Article
dcterms.dateAccepted2021-01-25
rioxxterms.versionVoRen
rioxxterms.versionofrecord10.1186/s12871-021-01268-yen
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0en
rioxxterms.licenseref.startdate2021-03-19
dc.relation.isPartOfBMC anesthesiologyen_US
pubs.issue1en_US
pubs.notesNo embargoen_US
pubs.organisational-group/ICR
pubs.publication-statusPublisheden_US
pubs.volume21en_US
pubs.embargo.termsNo embargoen_US
dc.contributor.icrauthorTasoulis, Mariosen_US


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