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Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

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Date
2017-05
ICR Author
Gore, Martin
Orr, Nicholas
Eeles, Rosalind
Swerdlow, Anthony
Schoemaker, Minouk
Banerjee, Susana
Marsden,
Jones, Michael
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Author
Phelan, CM
Kuchenbaecker, KB
Tyrer, JP
Kar, SP
Lawrenson, K
Winham, SJ
Dennis, J
Pirie, A
Riggan, MJ
Chornokur, G
Earp, MA
Lyra, PC
Lee, JM
Coetzee, S
Beesley, J
McGuffog, L
Soucy, P
Dicks, E
Lee, A
Barrowdale, D
Lecarpentier, J
Leslie, G
Aalfs, CM
Aben, KKH
Adams, M
Adlard, J
Andrulis, IL
Anton-Culver, H
Antonenkova, N
AOCS study group
Aravantinos, G
Arnold, N
Arun, BK
Arver, B
Azzollini, J
Balmaña, J
Banerjee, SN
Barjhoux, L
Barkardottir, RB
Bean, Y
Beckmann, MW
Beeghly-Fadiel, A
Benitez, J
Bermisheva, M
Bernardini, MQ
Birrer, MJ
Bjorge, L
Black, A
Blankstein, K
Blok, MJ
Bodelon, C
Bogdanova, N
Bojesen, A
Bonanni, B
Borg, Å
Bradbury, AR
Brenton, JD
Brewer, C
Brinton, L
Broberg, P
Brooks-Wilson, A
Bruinsma, F
Brunet, J
Buecher, B
Butzow, R
Buys, SS
Caldes, T
Caligo, MA
Campbell, I
Cannioto, R
Carney, ME
Cescon, T
Chan, SB
Chang-Claude, J
Chanock, S
Chen, XQ
Chiew, Y-E
Chiquette, J
Chung, WK
Claes, KBM
Conner, T
Cook, LS
Cook, J
Cramer, DW
Cunningham, JM
D'Aloisio, AA
Daly, MB
Damiola, F
Damirovna, SD
Dansonka-Mieszkowska, A
Dao, F
Davidson, R
DeFazio, A
Delnatte, C
Doheny, KF
Diez, O
Ding, YC
Doherty, JA
Domchek, SM
Dorfling, CM
Dörk, T
Dossus, L
Duran, M
Dürst, M
Dworniczak, B
Eccles, D
Edwards, T
Eeles, R
Eilber, U
Ejlertsen, B
Ekici, AB
Ellis, S
Elvira, M
EMBRACE Study
Eng, KH
Engel, C
Evans, DG
Fasching, PA
Ferguson, S
Ferrer, SF
Flanagan, JM
Fogarty, ZC
Fortner, RT
Fostira, F
Foulkes, WD
Fountzilas, G
Fridley, BL
Friebel, TM
Friedman, E
Frost, D
Ganz, PA
Garber, J
García, MJ
Garcia-Barberan, V
Gehrig, A
GEMO Study Collaborators
Gentry-Maharaj, A
Gerdes, A-M
Giles, GG
Glasspool, R
Glendon, G
Godwin, AK
Goldgar, DE
Goranova, T
Gore, M
Greene, MH
Gronwald, J
Gruber, S
Hahnen, E
Haiman, CA
Håkansson, N
Hamann, U
Hansen, TVO
Harrington, PA
Harris, HR
Hauke, J
HEBON Study
Hein, A
Henderson, A
Hildebrandt, MAT
Hillemanns, P
Hodgson, S
Høgdall, CK
Høgdall, E
Hogervorst, FBL
Holland, H
Hooning, MJ
Hosking, K
Huang, R-Y
Hulick, PJ
Hung, J
Hunter, DJ
Huntsman, DG
Huzarski, T
Imyanitov, EN
Isaacs, C
Iversen, ES
Izatt, L
Izquierdo, A
Jakubowska, A
James, P
Janavicius, R
Jernetz, M
Jensen, A
Jensen, UB
John, EM
Johnatty, S
Jones, ME
Kannisto, P
Karlan, BY
Karnezis, A
Kast, K
KConFab Investigators
Kennedy, CJ
Khusnutdinova, E
Kiemeney, LA
Kiiski, JI
Kim, S-W
Kjaer, SK
Köbel, M
Kopperud, RK
Kruse, TA
Kupryjanczyk, J
Kwong, A
Laitman, Y
Lambrechts, D
Larrañaga, N
Larson, MC
Lazaro, C
Le, ND
Le Marchand, L
Lee, JW
Lele, SB
Leminen, A
Leroux, D
Lester, J
Lesueur, F
Levine, DA
Liang, D
Liebrich, C
Lilyquist, J
Lipworth, L
Lissowska, J
Lu, KH
Lubinński, J
Luccarini, C
Lundvall, L
Mai, PL
Mendoza-Fandiño, G
Manoukian, S
Massuger, LFAG
May, T
Mazoyer, S
McAlpine, JN
McGuire, V
McLaughlin, JR
McNeish, I
Meijers-Heijboer, H
Meindl, A
Menon, U
Mensenkamp, AR
Merritt, MA
Milne, RL
Mitchell, G
Modugno, F
Moes-Sosnowska, J
Moffitt, M
Montagna, M
Moysich, KB
Mulligan, AM
Musinsky, J
Nathanson, KL
Nedergaard, L
Ness, RB
Neuhausen, SL
Nevanlinna, H
Niederacher, D
Nussbaum, RL
Odunsi, K
Olah, E
Olopade, OI
Olsson, H
Olswold, C
O'Malley, DM
Ong, K-R
Onland-Moret, NC
OPAL study group
Orr, N
Orsulic, S
Osorio, A
Palli, D
Papi, L
Park-Simon, T-W
Paul, J
Pearce, CL
Pedersen, IS
Peeters, PHM
Peissel, B
Peixoto, A
Pejovic, T
Pelttari, LM
Permuth, JB
Peterlongo, P
Pezzani, L
Pfeiler, G
Phillips, K-A
Piedmonte, M
Pike, MC
Piskorz, AM
Poblete, SR
Pocza, T
Poole, EM
Poppe, B
Porteous, ME
Prieur, F
Prokofyeva, D
Pugh, E
Pujana, MA
Pujol, P
Radice, P
Rantala, J
Rappaport-Fuerhauser, C
Rennert, G
Rhiem, K
Rice, P
Richardson, A
Robson, M
Rodriguez, GC
Rodríguez-Antona, C
Romm, J
Rookus, MA
Rossing, MA
Rothstein, JH
Rudolph, A
Runnebaum, IB
Salvesen, HB
Sandler, DP
Schoemaker, MJ
Senter, L
Setiawan, VW
Severi, G
Sharma, P
Shelford, T
Siddiqui, N
Side, LE
Sieh, W
Singer, CF
Sobol, H
Song, H
Southey, MC
Spurdle, AB
Stadler, Z
Steinemann, D
Stoppa-Lyonnet, D
Sucheston-Campbell, LE
Sukiennicki, G
Sutphen, R
Sutter, C
Swerdlow, AJ
Szabo, CI
Szafron, L
Tan, YY
Taylor, JA
Tea, M-K
Teixeira, MR
Teo, S-H
Terry, KL
Thompson, PJ
Thomsen, LCV
Thull, DL
Tihomirova, L
Tinker, AV
Tischkowitz, M
Tognazzo, S
Toland, AE
Tone, A
Trabert, B
Travis, RC
Trichopoulou, A
Tung, N
Tworoger, SS
van Altena, AM
Van Den Berg, D
van der Hout, AH
van der Luijt, RB
Van Heetvelde, M
Van Nieuwenhuysen, E
van Rensburg, EJ
Vanderstichele, A
Varon-Mateeva, R
Vega, A
Edwards, DV
Vergote, I
Vierkant, RA
Vijai, J
Vratimos, A
Walker, L
Walsh, C
Wand, D
Wang-Gohrke, S
Wappenschmidt, B
Webb, PM
Weinberg, CR
Weitzel, JN
Wentzensen, N
Whittemore, AS
Wijnen, JT
Wilkens, LR
Wolk, A
Woo, M
Wu, X
Wu, AH
Yang, H
Yannoukakos, D
Ziogas, A
Zorn, KK
Narod, SA
Easton, DF
Amos, CI
Schildkraut, JM
Ramus, SJ
Ottini, L
Goodman, MT
Park, SK
Kelemen, LE
Risch, HA
Thomassen, M
Offit, K
Simard, J
Schmutzler, RK
Hazelett, D
Monteiro, AN
Couch, FJ
Berchuck, A
Chenevix-Trench, G
Goode, EL
Sellers, TA
Gayther, SA
Antoniou, AC
Pharoah, PDP
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Type
Journal Article
Metadata
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Abstract
To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
URI
https://repository.icr.ac.uk/handle/internal/599
DOI
https://doi.org/10.1038/ng.3826
Collections
  • Breast Cancer Research
  • Genetics and Epidemiology
  • Radiotherapy and Imaging
Subject
AOCS study group
EMBRACE Study
GEMO Study Collaborators
HEBON Study
KConFab Investigators
OPAL study group
Humans
Neoplasms, Glandular and Epithelial
Ovarian Neoplasms
Genetic Predisposition to Disease
Telomere-Binding Proteins
BRCA1 Protein
BRCA2 Protein
Risk Factors
Genotype
Mutation
Polymorphism, Single Nucleotide
Alleles
Female
Meta-Analysis as Topic
Genome-Wide Association Study
Genetic Loci
Carcinoma, Ovarian Epithelial
Research team
Complex Trait Genetics
Aetiological Epidemiology
Oncogenetics
Language
eng
Date accepted
2017-03-03
License start date
2017-05
Citation
Nature genetics, 2017, 49 (5), pp. 680 - 691

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