Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.

Phelan, CM; Kuchenbaecker, KB; Tyrer, JP; Kar, SP; Lawrenson, K; Winham, SJ; Dennis, J; Pirie, A; Riggan, MJ; Chornokur, G; Earp, MA; Lyra, PC; Lee, JM; Coetzee, S; Beesley, J; McGuffog, L; Soucy, P; Dicks, E; Lee, A; Barrowdale, D; Lecarpentier, J; Leslie, G; Aalfs, CM; Aben, KKH; Adams, M; Adlard, J; Andrulis, IL; Anton-Culver, H; Antonenkova, N; AOCS study group; Aravantinos, G; Arnold, N; Arun, BK; Arver, B; Azzollini, J; Balmaña, J; Banerjee, SN; Barjhoux, L; Barkardottir, RB; Bean, Y; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bermisheva, M; Bernardini, MQ; Birrer, MJ; Bjorge, L; Black, A; Blankstein, K; Blok, MJ; Bodelon, C; Bogdanova, N; Bojesen, A; Bonanni, B; Borg, Å; Bradbury, AR; Brenton, JD; Brewer, C; Brinton, L; Broberg, P; Brooks-Wilson, A; Bruinsma, F; Brunet, J; Buecher, B; Butzow, R; Buys, SS; Caldes, T; Caligo, MA; Campbell, I; Cannioto, R; Carney, ME; Cescon, T; Chan, SB; Chang-Claude, J; Chanock, S; Chen, XQ; Chiew, Y-E; Chiquette, J; Chung, WK; Claes, KBM; Conner, T; Cook, LS; Cook, J; Cramer, DW; Cunningham, JM; D'Aloisio, AA; Daly, MB; Damiola, F; Damirovna, SD; Dansonka-Mieszkowska, A; Dao, F; Davidson, R; DeFazio, A; Delnatte, C; Doheny, KF; Diez, O; Ding, YC; Doherty, JA; Domchek, SM; Dorfling, CM; Dörk, T; Dossus, L; Duran, M; Dürst, M; Dworniczak, B; Eccles, D; Edwards, T; Eeles, R; Eilber, U; Ejlertsen, B; Ekici, AB; Ellis, S; Elvira, M; EMBRACE Study; Eng, KH; Engel, C; Evans, DG; Fasching, PA; Ferguson, S; Ferrer, SF; Flanagan, JM; Fogarty, ZC; Fortner, RT; Fostira, F; Foulkes, WD; Fountzilas, G; Fridley, BL; Friebel, TM; Friedman, E; Frost, D; Ganz, PA; Garber, J; García, MJ; Garcia-Barberan, V; Gehrig, A; GEMO Study Collaborators; Gentry-Maharaj, A; Gerdes, A-M; Giles, GG; Glasspool, R; Glendon, G; Godwin, AK; Goldgar, DE; Goranova, T; Gore, M; Greene, MH; Gronwald, J; Gruber, S; Hahnen, E; Haiman, CA; Håkansson, N; Hamann, U; Hansen, TVO; Harrington, PA; Harris, HR; Hauke, J; HEBON Study; Hein, A; Henderson, A; Hildebrandt, MAT; Hillemanns, P; Hodgson, S; Høgdall, CK; Høgdall, E; Hogervorst, FBL; Holland, H; Hooning, MJ; Hosking, K; Huang, R-Y; Hulick, PJ; Hung, J; Hunter, DJ; Huntsman, DG; Huzarski, T; Imyanitov, EN; Isaacs, C; Iversen, ES; Izatt, L; Izquierdo, A; Jakubowska, A; James, P; Janavicius, R; Jernetz, M; Jensen, A; Jensen, UB; John, EM; Johnatty, S; Jones, ME; Kannisto, P; Karlan, BY; Karnezis, A; Kast, K; KConFab Investigators; Kennedy, CJ; Khusnutdinova, E; Kiemeney, LA; Kiiski, JI; Kim, S-W; Kjaer, SK; Köbel, M; Kopperud, RK; Kruse, TA; Kupryjanczyk, J; Kwong, A; Laitman, Y; Lambrechts, D; Larrañaga, N; Larson, MC; Lazaro, C; Le, ND; Le Marchand, L; Lee, JW; Lele, SB; Leminen, A; Leroux, D; Lester, J; Lesueur, F; Levine, DA; Liang, D; Liebrich, C; Lilyquist, J; Lipworth, L; Lissowska, J; Lu, KH; Lubinński, J; Luccarini, C; Lundvall, L; Mai, PL; Mendoza-Fandiño, G; Manoukian, S; Massuger, LFAG; May, T; Mazoyer, S; McAlpine, JN; McGuire, V; McLaughlin, JR; McNeish, I; Meijers-Heijboer, H; Meindl, A; Menon, U; Mensenkamp, AR; Merritt, MA; Milne, RL; Mitchell, G; Modugno, F; Moes-Sosnowska, J; Moffitt, M; Montagna, M; Moysich, KB; Mulligan, AM; Musinsky, J; Nathanson, KL; Nedergaard, L; Ness, RB; Neuhausen, SL; Nevanlinna, H; Niederacher, D; Nussbaum, RL; Odunsi, K; Olah, E; Olopade, OI; Olsson, H; Olswold, C; O'Malley, DM; Ong, K-R; Onland-Moret, NC; OPAL study group; Orr, N; Orsulic, S; Osorio, A; Palli, D; Papi, L; Park-Simon, T-W; Paul, J; Pearce, CL; Pedersen, IS; Peeters, PHM; Peissel, B; Peixoto, A; Pejovic, T; Pelttari, LM; Permuth, JB; Peterlongo, P; Pezzani, L; Pfeiler, G; Phillips, K-A; Piedmonte, M; Pike, MC; Piskorz, AM; Poblete, SR; Pocza, T; Poole, EM; Poppe, B; Porteous, ME; Prieur, F; Prokofyeva, D; Pugh, E; Pujana, MA; Pujol, P; Radice, P; Rantala, J; Rappaport-Fuerhauser, C; Rennert, G; Rhiem, K; Rice, P; Richardson, A; Robson, M; Rodriguez, GC; Rodríguez-Antona, C; Romm, J; Rookus, MA; Rossing, MA; Rothstein, JH; Rudolph, A; Runnebaum, IB; Salvesen, HB; Sandler, DP; Schoemaker, MJ; Senter, L; Setiawan, VW; Severi, G; Sharma, P; Shelford, T; Siddiqui, N; Side, LE; Sieh, W; Singer, CF; Sobol, H; Song, H; Southey, MC; Spurdle, AB; Stadler, Z; Steinemann, D; Stoppa-Lyonnet, D; Sucheston-Campbell, LE; Sukiennicki, G; Sutphen, R; Sutter, C; Swerdlow, AJ; Szabo, CI; Szafron, L; Tan, YY; Taylor, JA; Tea, M-K; Teixeira, MR; Teo, S-H; Terry, KL; Thompson, PJ; Thomsen, LCV; Thull, DL; Tihomirova, L; Tinker, AV; Tischkowitz, M; Tognazzo, S; Toland, AE; Tone, A; Trabert, B; Travis, RC; Trichopoulou, A; Tung, N; Tworoger, SS; van Altena, AM; Van Den Berg, D; van der Hout, AH; van der Luijt, RB; Van Heetvelde, M; Van Nieuwenhuysen, E; van Rensburg, EJ; Vanderstichele, A; Varon-Mateeva, R; Vega, A; Edwards, DV; Vergote, I; Vierkant, RA; Vijai, J; Vratimos, A; Walker, L; Walsh, C; Wand, D; Wang-Gohrke, S; Wappenschmidt, B; Webb, PM; Weinberg, CR; Weitzel, JN; Wentzensen, N; Whittemore, AS; Wijnen, JT; Wilkens, LR; Wolk, A; Woo, M; Wu, X; Wu, AH; Yang, H; Yannoukakos, D; Ziogas, A; Zorn, KK; Narod, SA; Easton, DF; Amos, CI; Schildkraut, JM; Ramus, SJ; Ottini, L; Goodman, MT; Park, SK; Kelemen, LE; Risch, HA; Thomassen, M; Offit, K; Simard, J; Schmutzler, RK; Hazelett, D; Monteiro, AN; Couch, FJ; Berchuck, A; Chenevix-Trench, G; Goode, EL; Sellers, TA; Gayther, SA; Antoniou, AC; Pharoah, PDP

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Publication Date

2017-05

ICR Author

Author

Phelan, CM

Kuchenbaecker, KB

Tyrer, JP

Kar, SP

Lawrenson, K

Winham, SJ

Dennis, J

Pirie, A

Riggan, MJ

Chornokur, G

Earp, MA

Lyra, PC

Lee, JM

Coetzee, S

Beesley, J

McGuffog, L

Soucy, P

Dicks, E

Lee, A

Barrowdale, D

Lecarpentier, J

Leslie, G

Aalfs, CM

Aben, KKH

Adams, M

Adlard, J

Andrulis, IL

Anton-Culver, H

Antonenkova, N

AOCS study group

Aravantinos, G

Arnold, N

Arun, BK

Arver, B

Azzollini, J

Balmaña, J

Banerjee, SN

Barjhoux, L

Barkardottir, RB

Bean, Y

Beckmann, MW

Beeghly-Fadiel, A

Benitez, J

Bermisheva, M

Bernardini, MQ

Birrer, MJ

Bjorge, L

Black, A

Blankstein, K

Blok, MJ

Bodelon, C

Bogdanova, N

Bojesen, A

Bonanni, B

Borg, Å

Bradbury, AR

Brenton, JD

Brewer, C

Brinton, L

Broberg, P

Brooks-Wilson, A

Bruinsma, F

Brunet, J

Buecher, B

Butzow, R

Buys, SS

Caldes, T

Caligo, MA

Campbell, I

Cannioto, R

Carney, ME

Cescon, T

Chan, SB

Chang-Claude, J

Chanock, S

Chen, XQ

Chiew, Y-E

Chiquette, J

Chung, WK

Claes, KBM

Conner, T

Cook, LS

Cook, J

Cramer, DW

Cunningham, JM

D'Aloisio, AA

Daly, MB

Damiola, F

Damirovna, SD

Dansonka-Mieszkowska, A

Dao, F

Davidson, R

DeFazio, A

Delnatte, C

Doheny, KF

Diez, O

Ding, YC

Doherty, JA

Domchek, SM

Dorfling, CM

Dörk, T

Dossus, L

Duran, M

Dürst, M

Dworniczak, B

Eccles, D

Edwards, T

Eeles, R

Eilber, U

Ejlertsen, B

Ekici, AB

Ellis, S

Elvira, M

EMBRACE Study

Eng, KH

Engel, C

Evans, DG

Fasching, PA

Ferguson, S

Ferrer, SF

Flanagan, JM

Fogarty, ZC

Fortner, RT

Fostira, F

Foulkes, WD

Fountzilas, G

Fridley, BL

Friebel, TM

Friedman, E

Frost, D

Ganz, PA

Garber, J

García, MJ

Garcia-Barberan, V

Gehrig, A

GEMO Study Collaborators

Gentry-Maharaj, A

Gerdes, A-M

Giles, GG

Glasspool, R

Glendon, G

Godwin, AK

Goldgar, DE

Goranova, T

Gore, M

Greene, MH

Gronwald, J

Gruber, S

Hahnen, E

Haiman, CA

Håkansson, N

Hamann, U

Hansen, TVO

Harrington, PA

Harris, HR

Hauke, J

HEBON Study

Hein, A

Henderson, A

Hildebrandt, MAT

Hillemanns, P

Hodgson, S

Høgdall, CK

Høgdall, E

Hogervorst, FBL

Holland, H

Hooning, MJ

Hosking, K

Huang, R-Y

Hulick, PJ

Hung, J

Hunter, DJ

Huntsman, DG

Huzarski, T

Imyanitov, EN

Isaacs, C

Iversen, ES

Izatt, L

Izquierdo, A

Jakubowska, A

James, P

Janavicius, R

Jernetz, M

Jensen, A

Jensen, UB

John, EM

Johnatty, S

Jones, ME

Kannisto, P

Karlan, BY

Karnezis, A

Kast, K

KConFab Investigators

Kennedy, CJ

Khusnutdinova, E

Kiemeney, LA

Kiiski, JI

Kim, S-W

Kjaer, SK

Köbel, M

Kopperud, RK

Kruse, TA

Kupryjanczyk, J

Kwong, A

Laitman, Y

Lambrechts, D

Larrañaga, N

Larson, MC

Lazaro, C

Le, ND

Le Marchand, L

Lee, JW

Lele, SB

Leminen, A

Leroux, D

Lester, J

Lesueur, F

Levine, DA

Liang, D

Liebrich, C

Lilyquist, J

Lipworth, L

Lissowska, J

Lu, KH

Lubinński, J

Luccarini, C

Lundvall, L

Mai, PL

Mendoza-Fandiño, G

Manoukian, S

Massuger, LFAG

May, T

Mazoyer, S

McAlpine, JN

McGuire, V

McLaughlin, JR

McNeish, I

Meijers-Heijboer, H

Meindl, A

Menon, U

Mensenkamp, AR

Merritt, MA

Milne, RL

Mitchell, G

Modugno, F

Moes-Sosnowska, J

Moffitt, M

Montagna, M

Moysich, KB

Mulligan, AM

Musinsky, J

Nathanson, KL

Nedergaard, L

Ness, RB

Neuhausen, SL

Nevanlinna, H

Niederacher, D

Nussbaum, RL

Odunsi, K

Olah, E

Olopade, OI

Olsson, H

Olswold, C

O'Malley, DM

Ong, K-R

Onland-Moret, NC

OPAL study group

Orr, N

Orsulic, S

Osorio, A

Palli, D

Papi, L

Park-Simon, T-W

Paul, J

Pearce, CL

Pedersen, IS

Peeters, PHM

Peissel, B

Peixoto, A

Pejovic, T

Pelttari, LM

Permuth, JB

Peterlongo, P

Pezzani, L

Pfeiler, G

Phillips, K-A

Piedmonte, M

Pike, MC

Piskorz, AM

Poblete, SR

Pocza, T

Poole, EM

Poppe, B

Porteous, ME

Prieur, F

Prokofyeva, D

Pugh, E

Pujana, MA

Pujol, P

Radice, P

Rantala, J

Rappaport-Fuerhauser, C

Rennert, G

Rhiem, K

Rice, P

Richardson, A

Robson, M

Rodriguez, GC

Rodríguez-Antona, C

Romm, J

Rookus, MA

Rossing, MA

Rothstein, JH

Rudolph, A

Runnebaum, IB

Salvesen, HB

Sandler, DP

Schoemaker, MJ

Senter, L

Setiawan, VW

Severi, G

Sharma, P

Shelford, T

Siddiqui, N

Side, LE

Sieh, W

Singer, CF

Sobol, H

Song, H

Southey, MC

Spurdle, AB

Stadler, Z

Steinemann, D

Stoppa-Lyonnet, D

Sucheston-Campbell, LE

Sukiennicki, G

Sutphen, R

Sutter, C

Swerdlow, AJ

Szabo, CI

Szafron, L

Tan, YY

Taylor, JA

Tea, M-K

Teixeira, MR

Teo, S-H

Terry, KL

Thompson, PJ

Thomsen, LCV

Thull, DL

Tihomirova, L

Tinker, AV

Tischkowitz, M

Tognazzo, S

Toland, AE

Tone, A

Trabert, B

Travis, RC

Trichopoulou, A

Tung, N

Tworoger, SS

van Altena, AM

Van Den Berg, D

van der Hout, AH

van der Luijt, RB

Van Heetvelde, M

Van Nieuwenhuysen, E

van Rensburg, EJ

Vanderstichele, A

Varon-Mateeva, R

Vega, A

Edwards, DV

Vergote, I

Vierkant, RA

Vijai, J

Vratimos, A

Walker, L

Walsh, C

Wand, D

Wang-Gohrke, S

Wappenschmidt, B

Webb, PM

Weinberg, CR

Weitzel, JN

Wentzensen, N

Whittemore, AS

Wijnen, JT

Wilkens, LR

Wolk, A

Woo, M

Wu, X

Wu, AH

Yang, H

Yannoukakos, D

Ziogas, A

Zorn, KK

Narod, SA

Easton, DF

Amos, CI

Schildkraut, JM

Ramus, SJ

Ottini, L

Goodman, MT

Park, SK

Kelemen, LE

Risch, HA

Thomassen, M

Offit, K

Simard, J

Schmutzler, RK

Hazelett, D

Monteiro, AN

Couch, FJ

Berchuck, A

Chenevix-Trench, G

Goode, EL

Sellers, TA

Gayther, SA

Antoniou, AC

Pharoah, PDP

Type

Journal Article

Metadata

Show full item record

Abstract

To identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.

URL

https://repository.icr.ac.uk/handle/internal/599

Collections

Licenseref URL

http://www.rioxx.net/licenses/all-rights-reserved

Version of record

10.1038/ng.3826

Subject

AOCS study group

EMBRACE Study

GEMO Study Collaborators

HEBON Study

KConFab Investigators

OPAL study group

Humans

Neoplasms, Glandular and Epithelial

Ovarian Neoplasms

Genetic Predisposition to Disease

Telomere-Binding Proteins

BRCA1 Protein

BRCA2 Protein

Risk Factors

Genotype

Mutation

Polymorphism, Single Nucleotide

Alleles

Female

Meta-Analysis as Topic

Genome-Wide Association Study

Genetic Loci

Carcinoma, Ovarian Epithelial

Research team

Complex Trait Genetics

Aetiological Epidemiology

Oncogenetics

Language

eng

Date accepted

2017-03-03

License start date

2017-05

Citation

Nature genetics, 2017, 49 (5), pp. 680 - 691

Publications Repository

Publications Repository