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dc.contributor.authorPhelan, CM
dc.contributor.authorKuchenbaecker, KB
dc.contributor.authorTyrer, JP
dc.contributor.authorKar, SP
dc.contributor.authorLawrenson, K
dc.contributor.authorWinham, SJ
dc.contributor.authorDennis, J
dc.contributor.authorPirie, A
dc.contributor.authorRiggan, MJ
dc.contributor.authorChornokur, G
dc.contributor.authorEarp, MA
dc.contributor.authorLyra, PC
dc.contributor.authorLee, JM
dc.contributor.authorCoetzee, S
dc.contributor.authorBeesley, J
dc.contributor.authorMcGuffog, L
dc.contributor.authorSoucy, P
dc.contributor.authorDicks, E
dc.contributor.authorLee, A
dc.contributor.authorBarrowdale, D
dc.contributor.authorLecarpentier, J
dc.contributor.authorLeslie, G
dc.contributor.authorAalfs, CM
dc.contributor.authorAben, KKH
dc.contributor.authorAdams, M
dc.contributor.authorAdlard, J
dc.contributor.authorAndrulis, IL
dc.contributor.authorAnton-Culver, H
dc.contributor.authorAntonenkova, N
dc.contributor.authorAOCS study group,
dc.contributor.authorAravantinos, G
dc.contributor.authorArnold, N
dc.contributor.authorArun, BK
dc.contributor.authorArver, B
dc.contributor.authorAzzollini, J
dc.contributor.authorBalmaña, J
dc.contributor.authorBanerjee, SN
dc.contributor.authorBarjhoux, L
dc.contributor.authorBarkardottir, RB
dc.contributor.authorBean, Y
dc.contributor.authorBeckmann, MW
dc.contributor.authorBeeghly-Fadiel, A
dc.contributor.authorBenitez, J
dc.contributor.authorBermisheva, M
dc.contributor.authorBernardini, MQ
dc.contributor.authorBirrer, MJ
dc.contributor.authorBjorge, L
dc.contributor.authorBlack, A
dc.contributor.authorBlankstein, K
dc.contributor.authorBlok, MJ
dc.contributor.authorBodelon, C
dc.contributor.authorBogdanova, N
dc.contributor.authorBojesen, A
dc.contributor.authorBonanni, B
dc.contributor.authorBorg, Å
dc.contributor.authorBradbury, AR
dc.contributor.authorBrenton, JD
dc.contributor.authorBrewer, C
dc.contributor.authorBrinton, L
dc.contributor.authorBroberg, P
dc.contributor.authorBrooks-Wilson, A
dc.contributor.authorBruinsma, F
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dc.contributor.authorBuecher, B
dc.contributor.authorButzow, R
dc.contributor.authorBuys, SS
dc.contributor.authorCaldes, T
dc.contributor.authorCaligo, MA
dc.contributor.authorCampbell, I
dc.contributor.authorCannioto, R
dc.contributor.authorCarney, ME
dc.contributor.authorCescon, T
dc.contributor.authorChan, SB
dc.contributor.authorChang-Claude, J
dc.contributor.authorChanock, S
dc.contributor.authorChen, XQ
dc.contributor.authorChiew, Y-E
dc.contributor.authorChiquette, J
dc.contributor.authorChung, WK
dc.contributor.authorClaes, KBM
dc.contributor.authorConner, T
dc.contributor.authorCook, LS
dc.contributor.authorCook, J
dc.contributor.authorCramer, DW
dc.contributor.authorCunningham, JM
dc.contributor.authorD'Aloisio, AA
dc.contributor.authorDaly, MB
dc.contributor.authorDamiola, F
dc.contributor.authorDamirovna, SD
dc.contributor.authorDansonka-Mieszkowska, A
dc.contributor.authorDao, F
dc.contributor.authorDavidson, R
dc.contributor.authorDeFazio, A
dc.contributor.authorDelnatte, C
dc.contributor.authorDoheny, KF
dc.contributor.authorDiez, O
dc.contributor.authorDing, YC
dc.contributor.authorDoherty, JA
dc.contributor.authorDomchek, SM
dc.contributor.authorDorfling, CM
dc.contributor.authorDörk, T
dc.contributor.authorDossus, L
dc.contributor.authorDuran, M
dc.contributor.authorDürst, M
dc.contributor.authorDworniczak, B
dc.contributor.authorEccles, D
dc.contributor.authorEdwards, T
dc.contributor.authorEeles, R
dc.contributor.authorEilber, U
dc.contributor.authorEjlertsen, B
dc.contributor.authorEkici, AB
dc.contributor.authorEllis, S
dc.contributor.authorElvira, M
dc.contributor.authorEMBRACE Study,
dc.contributor.authorEng, KH
dc.contributor.authorEngel, C
dc.contributor.authorEvans, DG
dc.contributor.authorFasching, PA
dc.contributor.authorFerguson, S
dc.contributor.authorFerrer, SF
dc.contributor.authorFlanagan, JM
dc.contributor.authorFogarty, ZC
dc.contributor.authorFortner, RT
dc.contributor.authorFostira, F
dc.contributor.authorFoulkes, WD
dc.contributor.authorFountzilas, G
dc.contributor.authorFridley, BL
dc.contributor.authorFriebel, TM
dc.contributor.authorFriedman, E
dc.contributor.authorFrost, D
dc.contributor.authorGanz, PA
dc.contributor.authorGarber, J
dc.contributor.authorGarcía, MJ
dc.contributor.authorGarcia-Barberan, V
dc.contributor.authorGehrig, A
dc.contributor.authorGEMO Study Collaborators,
dc.contributor.authorGentry-Maharaj, A
dc.contributor.authorGerdes, A-M
dc.contributor.authorGiles, GG
dc.contributor.authorGlasspool, R
dc.contributor.authorGlendon, G
dc.contributor.authorGodwin, AK
dc.contributor.authorGoldgar, DE
dc.contributor.authorGoranova, T
dc.contributor.authorGore, M
dc.contributor.authorGreene, MH
dc.contributor.authorGronwald, J
dc.contributor.authorGruber, S
dc.contributor.authorHahnen, E
dc.contributor.authorHaiman, CA
dc.contributor.authorHåkansson, N
dc.contributor.authorHamann, U
dc.contributor.authorHansen, TVO
dc.contributor.authorHarrington, PA
dc.contributor.authorHarris, HR
dc.contributor.authorHauke, J
dc.contributor.authorHEBON Study,
dc.contributor.authorHein, A
dc.contributor.authorHenderson, A
dc.contributor.authorHildebrandt, MAT
dc.contributor.authorHillemanns, P
dc.contributor.authorHodgson, S
dc.contributor.authorHøgdall, CK
dc.contributor.authorHøgdall, E
dc.contributor.authorHogervorst, FBL
dc.contributor.authorHolland, H
dc.contributor.authorHooning, MJ
dc.contributor.authorHosking, K
dc.contributor.authorHuang, R-Y
dc.contributor.authorHulick, PJ
dc.contributor.authorHung, J
dc.contributor.authorHunter, DJ
dc.contributor.authorHuntsman, DG
dc.contributor.authorHuzarski, T
dc.contributor.authorImyanitov, EN
dc.contributor.authorIsaacs, C
dc.contributor.authorIversen, ES
dc.contributor.authorIzatt, L
dc.contributor.authorIzquierdo, A
dc.contributor.authorJakubowska, A
dc.contributor.authorJames, P
dc.contributor.authorJanavicius, R
dc.contributor.authorJernetz, M
dc.contributor.authorJensen, A
dc.contributor.authorJensen, UB
dc.contributor.authorJohn, EM
dc.contributor.authorJohnatty, S
dc.contributor.authorJones, ME
dc.contributor.authorKannisto, P
dc.contributor.authorKarlan, BY
dc.contributor.authorKarnezis, A
dc.contributor.authorKast, K
dc.contributor.authorKConFab Investigators,
dc.contributor.authorKennedy, CJ
dc.contributor.authorKhusnutdinova, E
dc.contributor.authorKiemeney, LA
dc.contributor.authorKiiski, JI
dc.contributor.authorKim, S-W
dc.contributor.authorKjaer, SK
dc.contributor.authorKöbel, M
dc.contributor.authorKopperud, RK
dc.contributor.authorKruse, TA
dc.contributor.authorKupryjanczyk, J
dc.contributor.authorKwong, A
dc.contributor.authorLaitman, Y
dc.contributor.authorLambrechts, D
dc.contributor.authorLarrañaga, N
dc.contributor.authorLarson, MC
dc.contributor.authorLazaro, C
dc.contributor.authorLe, ND
dc.contributor.authorLe Marchand, L
dc.contributor.authorLee, JW
dc.contributor.authorLele, SB
dc.contributor.authorLeminen, A
dc.contributor.authorLeroux, D
dc.contributor.authorLester, J
dc.contributor.authorLesueur, F
dc.contributor.authorLevine, DA
dc.contributor.authorLiang, D
dc.contributor.authorLiebrich, C
dc.contributor.authorLilyquist, J
dc.contributor.authorLipworth, L
dc.contributor.authorLissowska, J
dc.contributor.authorLu, KH
dc.contributor.authorLubinński, J
dc.contributor.authorLuccarini, C
dc.contributor.authorLundvall, L
dc.contributor.authorMai, PL
dc.contributor.authorMendoza-Fandiño, G
dc.contributor.authorManoukian, S
dc.contributor.authorMassuger, LFAG
dc.contributor.authorMay, T
dc.contributor.authorMazoyer, S
dc.contributor.authorMcAlpine, JN
dc.contributor.authorMcGuire, V
dc.contributor.authorMcLaughlin, JR
dc.contributor.authorMcNeish, I
dc.contributor.authorMeijers-Heijboer, H
dc.contributor.authorMeindl, A
dc.contributor.authorMenon, U
dc.contributor.authorMensenkamp, AR
dc.contributor.authorMerritt, MA
dc.contributor.authorMilne, RL
dc.contributor.authorMitchell, G
dc.contributor.authorModugno, F
dc.contributor.authorMoes-Sosnowska, J
dc.contributor.authorMoffitt, M
dc.contributor.authorMontagna, M
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dc.contributor.authorMusinsky, J
dc.contributor.authorNathanson, KL
dc.contributor.authorNedergaard, L
dc.contributor.authorNess, RB
dc.contributor.authorNeuhausen, SL
dc.contributor.authorNevanlinna, H
dc.contributor.authorNiederacher, D
dc.contributor.authorNussbaum, RL
dc.contributor.authorOdunsi, K
dc.contributor.authorOlah, E
dc.contributor.authorOlopade, OI
dc.contributor.authorOlsson, H
dc.contributor.authorOlswold, C
dc.contributor.authorO'Malley, DM
dc.contributor.authorOng, K-R
dc.contributor.authorOnland-Moret, NC
dc.contributor.authorOPAL study group,
dc.contributor.authorOrr, N
dc.contributor.authorOrsulic, S
dc.contributor.authorOsorio, A
dc.contributor.authorPalli, D
dc.contributor.authorPapi, L
dc.contributor.authorPark-Simon, T-W
dc.contributor.authorPaul, J
dc.contributor.authorPearce, CL
dc.contributor.authorPedersen, IS
dc.contributor.authorPeeters, PHM
dc.contributor.authorPeissel, B
dc.contributor.authorPeixoto, A
dc.contributor.authorPejovic, T
dc.contributor.authorPelttari, LM
dc.contributor.authorPermuth, JB
dc.contributor.authorPeterlongo, P
dc.contributor.authorPezzani, L
dc.contributor.authorPfeiler, G
dc.contributor.authorPhillips, K-A
dc.contributor.authorPiedmonte, M
dc.contributor.authorPike, MC
dc.contributor.authorPiskorz, AM
dc.contributor.authorPoblete, SR
dc.contributor.authorPocza, T
dc.contributor.authorPoole, EM
dc.contributor.authorPoppe, B
dc.contributor.authorPorteous, ME
dc.contributor.authorPrieur, F
dc.contributor.authorProkofyeva, D
dc.contributor.authorPugh, E
dc.contributor.authorPujana, MA
dc.contributor.authorPujol, P
dc.contributor.authorRadice, P
dc.contributor.authorRantala, J
dc.contributor.authorRappaport-Fuerhauser, C
dc.contributor.authorRennert, G
dc.contributor.authorRhiem, K
dc.contributor.authorRice, P
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dc.contributor.authorRodriguez, GC
dc.contributor.authorRodríguez-Antona, C
dc.contributor.authorRomm, J
dc.contributor.authorRookus, MA
dc.contributor.authorRossing, MA
dc.contributor.authorRothstein, JH
dc.contributor.authorRudolph, A
dc.contributor.authorRunnebaum, IB
dc.contributor.authorSalvesen, HB
dc.contributor.authorSandler, DP
dc.contributor.authorSchoemaker, MJ
dc.contributor.authorSenter, L
dc.contributor.authorSetiawan, VW
dc.contributor.authorSeveri, G
dc.contributor.authorSharma, P
dc.contributor.authorShelford, T
dc.contributor.authorSiddiqui, N
dc.contributor.authorSide, LE
dc.contributor.authorSieh, W
dc.contributor.authorSinger, CF
dc.contributor.authorSobol, H
dc.contributor.authorSong, H
dc.contributor.authorSouthey, MC
dc.contributor.authorSpurdle, AB
dc.contributor.authorStadler, Z
dc.contributor.authorSteinemann, D
dc.contributor.authorStoppa-Lyonnet, D
dc.contributor.authorSucheston-Campbell, LE
dc.contributor.authorSukiennicki, G
dc.contributor.authorSutphen, R
dc.contributor.authorSutter, C
dc.contributor.authorSwerdlow, AJ
dc.contributor.authorSzabo, CI
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dc.contributor.authorWappenschmidt, B
dc.contributor.authorWebb, PM
dc.contributor.authorWeinberg, CR
dc.contributor.authorWeitzel, JN
dc.contributor.authorWentzensen, N
dc.contributor.authorWhittemore, AS
dc.contributor.authorWijnen, JT
dc.contributor.authorWilkens, LR
dc.contributor.authorWolk, A
dc.contributor.authorWoo, M
dc.contributor.authorWu, X
dc.contributor.authorWu, AH
dc.contributor.authorYang, H
dc.contributor.authorYannoukakos, D
dc.contributor.authorZiogas, A
dc.contributor.authorZorn, KK
dc.contributor.authorNarod, SA
dc.contributor.authorEaston, DF
dc.contributor.authorAmos, CI
dc.contributor.authorSchildkraut, JM
dc.contributor.authorRamus, SJ
dc.contributor.authorOttini, L
dc.contributor.authorGoodman, MT
dc.contributor.authorPark, SK
dc.contributor.authorKelemen, LE
dc.contributor.authorRisch, HA
dc.contributor.authorThomassen, M
dc.contributor.authorOffit, K
dc.contributor.authorSimard, J
dc.contributor.authorSchmutzler, RK
dc.contributor.authorHazelett, D
dc.contributor.authorMonteiro, AN
dc.contributor.authorCouch, FJ
dc.contributor.authorBerchuck, A
dc.contributor.authorChenevix-Trench, G
dc.contributor.authorGoode, EL
dc.contributor.authorSellers, TA
dc.contributor.authorGayther, SA
dc.contributor.authorAntoniou, AC
dc.contributor.authorPharoah, PDP
dc.date.accessioned2017-04-13T11:11:15Z
dc.date.issued2017-05-01
dc.identifier.citationNature genetics, 2017, 49 (5), pp. 680 - 691
dc.identifier.issn1061-4036
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/599
dc.identifier.eissn1546-1718
dc.identifier.doi10.1038/ng.3826
dc.description.abstractTo identify common alleles associated with different histotypes of epithelial ovarian cancer (EOC), we pooled data from multiple genome-wide genotyping projects totaling 25,509 EOC cases and 40,941 controls. We identified nine new susceptibility loci for different EOC histotypes: six for serous EOC histotypes (3q28, 4q32.3, 8q21.11, 10q24.33, 18q11.2 and 22q12.1), two for mucinous EOC (3q22.3 and 9q31.1) and one for endometrioid EOC (5q12.3). We then performed meta-analysis on the results for high-grade serous ovarian cancer with the results from analysis of 31,448 BRCA1 and BRCA2 mutation carriers, including 3,887 mutation carriers with EOC. This identified three additional susceptibility loci at 2q13, 8q24.1 and 12q24.31. Integrated analyses of genes and regulatory biofeatures at each locus predicted candidate susceptibility genes, including OBFC1, a new candidate susceptibility gene for low-grade and borderline serous EOC.
dc.formatPrint-Electronic
dc.format.extent680 - 691
dc.languageeng
dc.language.isoeng
dc.publisherNATURE PORTFOLIO
dc.rights.urihttps://www.rioxx.net/licenses/all-rights-reserved
dc.subjectAOCS study group
dc.subjectEMBRACE Study
dc.subjectGEMO Study Collaborators
dc.subjectHEBON Study
dc.subjectKConFab Investigators
dc.subjectOPAL study group
dc.subjectHumans
dc.subjectNeoplasms, Glandular and Epithelial
dc.subjectOvarian Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectTelomere-Binding Proteins
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectRisk Factors
dc.subjectGenotype
dc.subjectMutation
dc.subjectPolymorphism, Single Nucleotide
dc.subjectAlleles
dc.subjectFemale
dc.subjectMeta-Analysis as Topic
dc.subjectGenome-Wide Association Study
dc.subjectGenetic Loci
dc.subjectCarcinoma, Ovarian Epithelial
dc.titleIdentification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer.
dc.typeJournal Article
dcterms.dateAccepted2017-03-03
rioxxterms.versionofrecord10.1038/ng.3826
rioxxterms.licenseref.urihttps://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2017-05
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfNature genetics
pubs.issue5
pubs.notes6 months
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR/Primary Group/Royal Marsden Clinical Units
pubs.publication-statusPublished
pubs.volume49
pubs.embargo.terms6 months
icr.researchteamComplex Trait Genetics
icr.researchteamAetiological Epidemiology
icr.researchteamOncogenetics
dc.contributor.icrauthorEeles, Rosalind
dc.contributor.icrauthorJones, Michael
dc.contributor.icrauthorSchoemaker, Minouk
dc.contributor.icrauthorSwerdlow, Anthony


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