Publications Repository

Publications Repository

View item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Integrated MRI-guided radiotherapy - opportunities and challenges.

Thumbnail
View/Open
Accepted version (1.026Mb)
Date
2022-04-19
ICR Author
Tree, Alison
Author
Keall, PJ
Brighi, C
Glide-Hurst, C
Liney, G
Liu, PZY
Lydiard, S
Paganelli, C
Pham, T
Shan, S
Tree, AC
van der Heide, UA
Waddington, DEJ
Whelan, B
Show allShow less
Type
Journal Article
Metadata
Show full item record
Abstract
MRI can help to categorize tissues as malignant or non-malignant both anatomically and functionally, with a high level of spatial and temporal resolution. This non-invasive imaging modality has been integrated with radiotherapy in devices that can differentially target the most aggressive and resistant regions of tumours. The past decade has seen the clinical deployment of treatment devices that combine imaging with targeted irradiation, making the aspiration of integrated MRI-guided radiotherapy (MRIgRT) a reality. The two main clinical drivers for the adoption of MRIgRT are the ability to image anatomical changes that occur before and during treatment in order to adapt the treatment approach, and to image and target the biological features of each tumour. Using motion management and biological targeting, the radiation dose delivered to the tumour can be adjusted during treatment to improve the probability of tumour control, while simultaneously reducing the radiation delivered to non-malignant tissues, thereby reducing the risk of treatment-related toxicities. The benefits of this approach are expected to increase survival and quality of life. In this Review, we describe the current state of MRIgRT, and the opportunities and challenges of this new radiotherapy approach.
URI
https://repository.icr.ac.uk/handle/internal/5163
DOI
https://doi.org/10.1038/s41571-022-00631-3
https://doi.org/10.1038/s41571-022-00631-3
 
Collections
  • Other ICR Research
Language
eng
Date accepted
2022-03-31
License start date
2022-04-19
Citation
Nature reviews. Clinical oncology, 2022

Browse

All of ICR repositoryICR DivisionsBy issue dateAuthorsTitlesPublication TypesThis collectionBy issue dateAuthorsTitlesPublication Types
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.