Low-grade serous ovarian cancer: expert consensus report on the state of the science.
Date
2023-09-04ICR Author
Author
Grisham, RN
Slomovitz, BM
Andrews, N
Banerjee, S
Brown, J
Carey, MS
Chui, H
Coleman, RL
Fader, AN
Gaillard, S
Gourley, C
Sood, AK
Monk, BJ
Moore, KN
Ray-Coquard, I
Shih, I-M
Westin, SN
Wong, K-K
Gershenson, DM
Type
Journal Article
Metadata
Show full item recordAbstract
Compared with high-grade serous carcinoma, low-grade serous carcinoma of the ovary or peritoneum is a less frequent epithelial ovarian cancer type that is poorly sensitive to chemotherapy and affects younger women, many of whom endure years of ineffective treatments and poor quality of life. The pathogenesis of this disease and its management remain incompletely understood. However, recent advances in the molecular characterization of the disease and identification of novel targeted therapies with activity in low-grade serous carcinoma offer the promise of improved outcomes. To update clinicians regarding recent scientific and clinical trial advancements and discuss unanswered questions related to low-grade serous carcinoma diagnosis and treatment, a panel of experts convened for a workshop in October 2022 to develop a consensus document addressing pathology, translational research, epidemiology and risk, clinical management, and ongoing research. In addition, the patient perspective was discussed. The recommendations developed by this expert panel-presented in this consensus document-will guide practitioners in all settings regarding the clinical management of women with low-grade serous carcinoma and discuss future opportunities to improve research and patient care.
Collections
Subject
Cystadenocarcinoma, Serous
Ovarian Cancer
Pathology
Humans
Female
Consensus
Quality of Life
Peritoneal Neoplasms
Carcinoma, Ovarian Epithelial
Cystadenocarcinoma, Papillary
Cystadenocarcinoma, Serous
Ovarian Neoplasms
Language
eng
Date accepted
2023-07-24
License start date
2023-09-04
Citation
International Journal of Gynecological Cancer, 2023, 33 (9), pp. 1331 - 1344
Publisher
BMJ PUBLISHING GROUP