dc.contributor.author | Sud, A | |
dc.contributor.author | Thomsen, H | |
dc.contributor.author | Law, PJ | |
dc.contributor.author | Försti, A | |
dc.contributor.author | Filho, MIDS | |
dc.contributor.author | Holroyd, A | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Orlando, G | |
dc.contributor.author | Lenive, O | |
dc.contributor.author | Wright, L | |
dc.contributor.author | Cooke, R | |
dc.contributor.author | Easton, D | |
dc.contributor.author | Pharoah, P | |
dc.contributor.author | Dunning, A | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | PRACTICAL consortium, | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | Strandmann, EPV | |
dc.contributor.author | Lightfoot, T | |
dc.contributor.author | Kane, E | |
dc.contributor.author | Roman, E | |
dc.contributor.author | Lake, A | |
dc.contributor.author | Montgomery, D | |
dc.contributor.author | Jarrett, RF | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Engert, A | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Hemminki, K | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2017-12-01T12:18:22Z | |
dc.date.issued | 2017-12-01 | |
dc.identifier.citation | Nature communications, 2017, 8 (1), pp. 1892 - ? | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/961 | |
dc.identifier.eissn | 2041-1723 | |
dc.identifier.doi | 10.1038/s41467-017-00320-1 | |
dc.description.abstract | Several susceptibility loci for classical Hodgkin lymphoma have been reported. However, much of the heritable risk is unknown. Here, we perform a meta-analysis of two existing genome-wide association studies, a new genome-wide association study, and replication totalling 5,314 cases and 16,749 controls. We identify risk loci for all classical Hodgkin lymphoma at 6q22.33 (rs9482849, P = 1.52 × 10-8) and for nodular sclerosis Hodgkin lymphoma at 3q28 (rs4459895, P = 9.43 × 10-17), 6q23.3 (rs6928977, P = 4.62 × 10-11), 10p14 (rs3781093, P = 9.49 × 10-13), 13q34 (rs112998813, P = 4.58 × 10-8) and 16p13.13 (rs34972832, P = 2.12 × 10-8). Additionally, independent loci within the HLA region are observed for nodular sclerosis Hodgkin lymphoma (rs9269081, HLA-DPB1*03:01, Val86 in HLA-DRB1) and mixed cellularity Hodgkin lymphoma (rs1633096, rs13196329, Val86 in HLA-DRB1). The new and established risk loci localise to areas of active chromatin and show an over-representation of transcription factor binding for determinants of B-cell development and immune response. | |
dc.format | Electronic | |
dc.format.extent | 1892 - ? | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | NATURE PUBLISHING GROUP | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | |
dc.subject | PRACTICAL consortium | |
dc.subject | Humans | |
dc.subject | Hodgkin Disease | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Alleles | |
dc.subject | Genome-Wide Association Study | |
dc.subject | HLA-DRB1 Chains | |
dc.subject | HLA-DP beta-Chains | |
dc.title | Genome-wide association study of classical Hodgkin lymphoma identifies key regulators of disease susceptibility. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2017-06-20 | |
rioxxterms.versionofrecord | 10.1038/s41467-017-00320-1 | |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by/4.0 | |
rioxxterms.licenseref.startdate | 2017-12 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Nature communications | |
pubs.issue | 1 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 8 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Houlston, Richard | |