CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
View/ Open
Date
2017-07-26Author
Bridgett, S
Campbell, J
Lord, CJ
Ryan, CJ
Type
Journal Article
Metadata
Show full item recordAbstract
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
Collections
Subject
Cell Line, Tumor
Humans
Neoplasms
Genetic Predisposition to Disease
RNA, Small Interfering
Gene Expression Profiling
Genomics
Genotype
Systems Integration
Software
Health Resources
Genetic Testing
Clustered Regularly Interspaced Short Palindromic Repeats
Datasets as Topic
Precision Medicine
Research team
Gene Function
Language
eng
Date accepted
2017-06-08
License start date
2017-07-12
Citation
Cell systems, 2017, 5 (1), pp. 82 - 86.e3
Publisher
CELL PRESS