Browsing Other ICR Research by author "Kelland, Lloyd"
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High levels of the MDM2 oncogene in paediatric rhabdomyosarcoma cell lines may confer multidrug resistance
Cocker, HA; Hobbs, SM; Tiffin, N; Pritchard-Jones, K; Pinkerton, CR; et al. (2001-11-30)The MDM2 protein is known to be overexpressed in some sarcomas including rhabdomyosarcoma. However, the extent to which the MDM2 protein influences sensitivity to chemotherapeutic drugs is unclear. We have analysed this ... -
Short tandem repeat profiling provides an international reference standard for human cell lines
Masters, JR; Thomson, JA; Daly-Burns, B; Reid, YA; Dirks, WG; et al. (NATL ACAD SCIENCES, 2001-07-03)Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species ... -
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
Read, M; Harrison, RJ; Romagnoli, B; Tanious, FA; Gowan, SH; et al. (2001-04-24)The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ... -
Variation in RNA expression and genomic DNA content acquired during cell culture
Hiorns, LR; Bradshaw, TD; Skelton, LA; Yu, Q; Kelland, LR; et al. (NATURE PUBLISHING GROUP, 2004-02-26)Specific chromosomal abnormalities are increasingly recognised to be associated with particular tumour subtypes. These cytogenetic abnormalities define the sites of specific genes, the alteration of which is implicated in ...