Browsing Other ICR Research by author "Behrens, Axel"
Now showing items 1-16 of 16
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Are There Specific Cancer Stem Cell Markers?
Lan, L; Behrens, A (AMER ASSOC CANCER RESEARCH, 2023-01-18)The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise ... -
Cep55 promotes cytokinesis of neural progenitors but is dispensable for most mammalian cell divisions.
Tedeschi, A; Almagro, J; Renshaw, MJ; Messal, HA; Behrens, A; et al. (NATURE PUBLISHING GROUP, 2020-04-08)In mammalian cell lines, the endosomal sorting complex required for transport (ESCRT)-III mediates abscission, the process that physically separates daughter cells and completes cell division. Cep55 protein is regarded as ... -
Deficient adaptation to centrosome duplication defects in neural progenitors causes microcephaly and subcortical heterotopias.
González-Martínez, J; Cwetsch, AW; Martínez-Alonso, D; López-Sainz, LR; Almagro, J; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2021-08-23)Congenital microcephaly (MCPH) is a neurodevelopmental disease associated with mutations in genes encoding proteins involved in centrosomal and chromosomal dynamics during mitosis. Detailed MCPH pathogenesis at the cellular ... -
Dual-view oblique plane microscopy (dOPM).
Sparks, H; Dent, L; Bakal, C; Behrens, A; Salbreux, G; et al. (OPTICAL SOC AMER, 2020-12-01)We present a new folded dual-view oblique plane microscopy (OPM) technique termed dOPM that enables two orthogonal views of the sample to be obtained by translating a pair of tilted mirrors in refocussing space. Using a ... -
High expression of vinculin predicts poor prognosis and distant metastasis and associates with influencing tumor-associated NK cell infiltration and epithelial-mesenchymal transition in gastric cancer.
Li, H; Wang, C; Lan, L; Behrens, A; Tomaschko, M; et al. (IMPACT JOURNALS LLC, 2021-02-01)In the process of epithelial-mesenchymal transition (EMT), epithelial cancer cells transdifferentiate into mesenchymal-like cells with high motility and aggressiveness, resulting in the spread of tumor cells. Immune cells ... -
An intrinsic temporal order of c-JUN N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment.
Waudby, CA; Alvarez-Teijeiro, S; Josue Ruiz, E; Suppinger, S; Pinotsis, N; et al. (Springer Science and Business Media LLC, 2022-10-17)Protein phosphorylation is a major regulatory mechanism of cellular signalling. The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the ... -
LUBAC determines chemotherapy resistance in squamous cell lung cancer.
Ruiz, EJ; Diefenbacher, ME; Nelson, JK; Sancho, R; Pucci, F; et al. (ROCKEFELLER UNIV PRESS, 2019-02-04)Lung squamous cell carcinoma (LSCC) and adenocarcinoma (LADC) are the most common lung cancer subtypes. Molecular targeted treatments have improved LADC patient survival but are largely ineffective in LSCC. The tumor ... -
MEKK3 coordinates with FBW7 to regulate WDR62 stability and neurogenesis.
Xu, D; Yao, M; Wang, Y; Yuan, L; Hoeck, JD; et al. (PUBLIC LIBRARY SCIENCE, 2018-12-01)Mutations of WD repeat domain 62 (WDR62) lead to autosomal recessive primary microcephaly (MCPH), and down-regulation of WDR62 expression causes the loss of neural progenitor cells (NPCs). However, how WDR62 is regulated ... -
Proteasomal degradation of the tumour suppressor FBW7 requires branched ubiquitylation by TRIP12.
Khan, OM; Almagro, J; Nelson, JK; Horswell, S; Encheva, V; et al. (NATURE RESEARCH, 2021-04-06)The tumour suppressor FBW7 is a substrate adaptor for the E3 ubiquitin ligase complex SKP1-CUL1-F-box (SCF), that targets several oncoproteins for proteasomal degradation. FBW7 is widely mutated and FBW7 protein levels are ... -
The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer.
Khan, OM; Carvalho, J; Spencer-Dene, B; Mitter, R; Frith, D; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2018-04-02)The tumor suppressor FBW7 targets oncoproteins such as c-MYC for ubiquitylation and is mutated in several human cancers. We noted that in a substantial percentage of colon cancers, FBW7 protein is undetectable despite the ... -
The deubiquitylase USP9X controls ribosomal stalling.
Clancy, A; Heride, C; Pinto-Fernández, A; Elcocks, H; Kallinos, A; et al. (ROCKEFELLER UNIV PRESS, 2021-03-01)When a ribosome stalls during translation, it runs the risk of collision with a trailing ribosome. Such an encounter leads to the formation of a stable di-ribosome complex, which needs to be resolved by a dedicated machinery. ... -
The Jun-dependent axon regeneration gene program: Jun promotes regeneration over plasticity.
Mason, MRJ; van Erp, S; Wolzak, K; Behrens, A; Raivich, G; et al. (OXFORD UNIV PRESS, 2022-04-22)The regeneration-associated gene (RAG) expression program is activated in injured peripheral neurons after axotomy and enables long-distance axon re-growth. Over 1000 genes are regulated, and many transcription factors are ... -
The roles of intratumour heterogeneity in the biology and treatment of pancreatic ductal adenocarcinoma.
Evan, T; Wang, VM-Y; Behrens, A (SPRINGERNATURE, 2022-10-14)Intratumour heterogeneity (ITH) has become an important focus of cancer research in recent years. ITH describes the cellular variation that enables tumour evolution, including tumour progression, metastasis and resistance ... -
Tissue architecture in tumor initiation and progression.
Almagro, J; Messal, HA; Elosegui-Artola, A; van Rheenen, J; Behrens, A (CELL PRESS, 2022-06-01)The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the ... -
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, HA; Alt, S; Ferreira, RMM; Gribben, C; Wang, VM-Y; et al. (NATURE PUBLISHING GROUP, 2019-02-07)Tubular epithelia are a basic building block of organs and a common site of cancer occurrence1-4. During tumorigenesis, transformed cells overproliferate and epithelial architecture is disrupted. However, the biophysical ... -
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz, EJ; Pinto-Fernandez, A; Turnbull, AP; Lan, L; Charlton, TM; et al. (eLIFE SCIENCES PUBL LTD, 2021-10-12)Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient's 5-year survival rate is less than 5%. The ...