Browsing Other ICR Research by author "Greber, Basil"

Now showing items 1-6 of 6

    • 2.5 Å-resolution structure of human CDK-activating kinase bound to the clinical inhibitor ICEC0942. 

      Greber, BJ; Remis, J; Ali, S; Nogales, E (CELL PRESS, 2021-02-16)
      The human CDK-activating kinase (CAK), composed of CDK7, cyclin H, and MAT1, is involved in the control of transcription initiation and the cell cycle. Because of these activities, it has been identified as a promising ...

    • Insertion of the Biogenesis Factor Rei1 Probes the Ribosomal Tunnel during 60S Maturation. 

      Greber, BJ; Gerhardy, S; Leitner, A; Leibundgut, M; Salem, M; et al. (CELL PRESS, 2016-01-14)
      Eukaryotic ribosome biogenesis depends on several hundred assembly factors to produce functional 40S and 60S ribosomal subunits. The final phase of 60S subunit biogenesis is cytoplasmic maturation, which includes the ...

    • Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome. 

      Greber, BJ; Bieri, P; Leibundgut, M; Leitner, A; Aebersold, R; et al. (AMER ASSOC ADVANCEMENT SCIENCE, 2015-04-17)
      Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded membrane proteins that are critical for mitochondrial function. Here we present the complete atomic structure of the porcine 55S mitoribosome ...

    • The complete structure of the human TFIIH core complex. 

      Greber, BJ; Toso, DB; Fang, J; Nogales, E (ELIFE SCIENCES PUBLICATIONS LTD, 2019-03-12)
      Transcription factor IIH (TFIIH) is a heterodecameric protein complex critical for transcription initiation by RNA polymerase II and nucleotide excision DNA repair. The TFIIH core complex is sufficient for its repair ...

    • The cryo-electron microscopy structure of human transcription factor IIH. 

      Greber, BJ; Nguyen, THD; Fang, J; Afonine, PV; Adams, PD; et al. (NATURE PUBLISHING GROUP, 2017-09-21)
      Human transcription factor IIH (TFIIH) is part of the general transcriptional machinery required by RNA polymerase II for the initiation of eukaryotic gene transcription. Composed of ten subunits that add up to a molecular ...

    • The cryoelectron microscopy structure of the human CDK-activating kinase. 

      Greber, BJ; Perez-Bertoldi, JM; Lim, K; Iavarone, AT; Toso, DB; et al. (NATL ACAD SCIENCES, 2020-09-15)
      The human CDK-activating kinase (CAK), a complex composed of cyclin-dependent kinase (CDK) 7, cyclin H, and MAT1, is a critical regulator of transcription initiation and the cell cycle. It acts by phosphorylating the ...