Browsing Other ICR Research by title
Now showing items 453-472 of 612
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The reproductive ecology drivers of egg attendance in amphibians.
(WILEY, 2022-10-01)Parental care is extremely diverse but, despite much research, why parental care evolves is poorly understood. Here we address this outstanding question using egg attendance, the simplest and most common care form in many ... -
Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer.
(CELL PRESS, 2019-07-02)Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancers. Despite its efficacy, ∼40% of women relapse with ET-resistant (ETR) disease. A global transcription analysis in ETR cells ... -
Resolving genetic heterogeneity in cancer.
(NATURE PUBLISHING GROUP, 2019-07-01)To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the genetic landscape of most cancer types, and ... -
Results from London Regional Clinical Genetics services over a 5-year period on germline TP53 testing in women diagnosed with breast cancer at <30 years.
(BMJ PUBLISHING GROUP, 2022-06-01)BACKGROUND: The most common cancer diagnosed in germline TP53 pathogenic variant (PV) carriers is premenopausal breast cancer. An increased rate of breast tumour HER2 positivity has been reported in this group. Screening ... -
Retrospective analysis of North West London healthcare utilisation by children during the COVID-19 pandemic.
(BMJ PUBLISHING GROUP, 2022-01-01)OBJECTIVE: To explore the impact of the measures taken to combat COVID-19 on the patterns of acute illness in children presenting to primary and secondary care for North West London. DESIGN/SETTING/PARTICIPANTS: Retrospective ... -
Reusable respirators as personal protective equipment during ENT surgery.
(CAMBRIDGE UNIV PRESS, 2020-08-01)BACKGROUND: Robust personal protective equipment is essential in preventing the transmission of coronavirus disease 2019 to head and neck surgeons who are routinely involved in aerosol generating procedures. OBJECTIVE: ... -
Review: The HSP90 molecular chaperone—an enigmatic ATPase
(Wiley, 2016-08-01)<jats:title>ABSTRACT</jats:title><jats:p>The HSP90 molecular chaperone is involved in the activation and cellular stabilization of a range of ‘client’ proteins, of which oncogenic protein kinases and nuclear steroid hormone ... -
Rheo-optics of concentrated kaolinite suspensions
(ELSEVIER SCIENCE BV, 1996-06-14) -
Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome.
(AMER ASSOC ADVANCEMENT SCIENCE, 2015-04-17)Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded membrane proteins that are critical for mitochondrial function. Here we present the complete atomic structure of the porcine 55S mitoribosome ... -
Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20-44 years: the UK National Case-Control Study of Cervical Cancer
(2003-12-01)We report results on risk factors for invasive squamous cell and adenocarcinomas of the cervix in women aged 20-44 years from the UK National Case-Control Study of Cervical Cancer, including 180 women with adenocarcinoma, ... -
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults.
(NATURE PORTFOLIO, 2023-12-01)Over one million European children undergo computed tomography (CT) scans annually. Although moderate- to high-dose ionizing radiation exposure is an established risk factor for hematological malignancies, risks at CT ... -
Risk of second primary cancer among women in the Kaiser Permanente Breast Cancer Survivors Cohort.
(BMC, 2023-05-03)BACKGROUND: Breast cancer survivors are living longer due to early detection and advances in treatment and are at increased risk for second primary cancers. Comprehensive evaluation of second cancer risk among patients ... -
Roles of cancer associated fibroblasts in squamous cell carcinoma
(Institute of Cancer Research (University Of London), 2021-03-31)Cancer associated fibroblasts (CAFs) play a key role in the tumour microenvironment (TME) of squamous cell carcinoma. Influenced by cues from cancer cells, CAFS remodel the extracellular matrix and secrete cytokines and ... -
RORγt+ Innate Lymphoid Cells Promote Lymph Node Metastasis of Breast Cancers.
(AMER ASSOC CANCER RESEARCH, 2017-03-01)Cancer cells tend to metastasize first to tumor-draining lymph nodes, but the mechanisms mediating cancer cell invasion into the lymphatic vasculature remain little understood. Here, we show that in the human breast tumor ... -
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex.
(Springer Science and Business Media LLC, 2018-04-16)The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such as mTOR. However, the mechanism by which this ... -
Safety and Feasibility of Surgery for Oropharyngeal Cancers During the SARS-CoV-2-Pandemic.
(FRONTIERS MEDIA SA, 2021-03-24) -
Safety of intrauterine devices in MRI.
(2018-01)Objectives The paucity of safety information on intrauterine devices (IUD) for magnetic resonance imaging (MRI) examinations is clinically relevant. The aim of this study is to evaluate the MRI safety of clinically used ...