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Protein and drug interactions in the minor groove of DNA
(2002-03-01)
Interactions between proteins, drugs, water and B-DNA minor groove have been analyzed in crystal structures of 60 protein-DNA and 14 drug-DNA complexes. It was found that only purine N3, pyrimidine O2, guanine N2 and ...
Demonstration of correlations between clinical and physical image quality measures in chest and lumbar spine screen-film radiography
(BRITISH INST RADIOLOGY, 2001-06)
The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between ...
Short tandem repeat profiling provides an international reference standard for human cell lines
(NATL ACAD SCIENCES, 2001-07-03)
Cross-contamination between cell lines is a longstanding and frequent cause of scientific misrepresentation. Estimates from national testing services indicate that up to 36% of cell lines are of a different origin or species ...
Occupational, domestic and environmental mesothelioma risks in the British population: a case-control study
(NATURE PUBLISHING GROUP, 2009-03-31)
We obtained lifetime occupational and residential histories by telephone interview with 622 mesothelioma patients (512 men, 110 women) and 1420 population controls. Odds ratios (ORs) were converted to lifetime risk (LR) ...
Kinetic energy of He atoms in liquid He-4-He-3 mixtures
(AMER PHYSICAL SOC, 2003-12)
Deep inelastic neutron scattering measurements on liquid He-3-He-4 mixtures in the normal phase have been performed on the VESUVIO spectrometer at the ISIS pulsed neutron source at exchanged wave vectors of about qsimilar ...
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
(2001-04-24)
The telomerase enzyme is a potential therapeutic target in many human cancers. A series of potent inhibitors has been designed by computer modeling, which exploit the unique structural features of quadruplex DNA, These ...
Comparative genomics in chicken and Pekin duck using FISH mapping and microarray analysis
(BIOMED CENTRAL LTD, 2009-08)
Background: The availability of the complete chicken (Gallus gallus) genome sequence as well as a large number of chicken probes for fluorescent in-situ hybridization (FISH) and microarray resources facilitate comparative ...
Functional characterization of E- and P-cadherin in invasive breast cancer cells
(BIOMED CENTRAL LTD, 2009-03-03)
Background: Alterations in the cadherin-catenin adhesion complexes are involved in tumor initiation, progression and metastasis. However, the functional implication of distinct cadherin types in breast cancer biology is ...
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
(COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2007-11-01)
Oncogenic mutations of the MLL histone methyltransferase confer an unusual ability to transform non-self-renewing myeloid progenitors into leukemia stem cells (LSCs) by mechanisms that remain poorly defined. Misregulation ...