dc.contributor.author | Sud, A | |
dc.contributor.author | Thomsen, H | |
dc.contributor.author | Orlando, G | |
dc.contributor.author | Försti, A | |
dc.contributor.author | Law, PJ | |
dc.contributor.author | Broderick, P | |
dc.contributor.author | Cooke, R | |
dc.contributor.author | Hariri, F | |
dc.contributor.author | Pastinen, T | |
dc.contributor.author | Easton, DF | |
dc.contributor.author | Pharoah, PDP | |
dc.contributor.author | Dunning, AM | |
dc.contributor.author | Peto, J | |
dc.contributor.author | Canzian, F | |
dc.contributor.author | Eeles, R | |
dc.contributor.author | Kote-Jarai, Z | |
dc.contributor.author | Muir, K | |
dc.contributor.author | Pashayan, N | |
dc.contributor.author | Campa, D | |
dc.contributor.author | PRACTICAL Consortium, | |
dc.contributor.author | Hoffmann, P | |
dc.contributor.author | Nöthen, MM | |
dc.contributor.author | Jöckel, K-H | |
dc.contributor.author | von Strandmann, EP | |
dc.contributor.author | Swerdlow, AJ | |
dc.contributor.author | Engert, A | |
dc.contributor.author | Orr, N | |
dc.contributor.author | Hemminki, K | |
dc.contributor.author | Houlston, RS | |
dc.date.accessioned | 2018-08-21T10:29:55Z | |
dc.date.issued | 2018-11-08 | |
dc.identifier.citation | Blood, 2018, 132 (19), pp. 2040 - 2052 | |
dc.identifier.issn | 0006-4971 | |
dc.identifier.uri | https://repository.icr.ac.uk/handle/internal/2360 | |
dc.identifier.eissn | 1528-0020 | |
dc.identifier.doi | 10.1182/blood-2018-06-855296 | |
dc.description.abstract | To further our understanding of inherited susceptibility to Hodgkin lymphoma (HL), we performed a meta-analysis of 7 genome-wide association studies totaling 5325 HL cases and 22 423 control patients. We identify 5 new HL risk loci at 6p21.31 (rs649775; P = 2.11 × 10-10), 6q23.3 (rs1002658; P = 2.97 × 10-8), 11q23.1 (rs7111520; P = 1.44 × 10-11), 16p11.2 (rs6565176; P = 4.00 × 10-8), and 20q13.12 (rs2425752; P = 2.01 × 10-8). Integration of gene expression, histone modification, and in situ promoter capture Hi-C data at the 5 new and 13 known risk loci implicates dysfunction of the germinal center reaction, disrupted T-cell differentiation and function, and constitutive NF-κB activation as mechanisms of predisposition. These data provide further insights into the genetic susceptibility and biology of HL. | |
dc.format | Print-Electronic | |
dc.format.extent | 2040 - 2052 | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | AMER SOC HEMATOLOGY | |
dc.rights.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
dc.subject | PRACTICAL Consortium | |
dc.subject | Germinal Center | |
dc.subject | T-Lymphocytes | |
dc.subject | Cell Line, Tumor | |
dc.subject | Humans | |
dc.subject | Hodgkin Disease | |
dc.subject | Genetic Predisposition to Disease | |
dc.subject | NF-kappa B | |
dc.subject | Immunity | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Histone Code | |
dc.subject | Polymorphism, Single Nucleotide | |
dc.subject | Promoter Regions, Genetic | |
dc.subject | Genome-Wide Association Study | |
dc.subject | Genetic Loci | |
dc.title | Genome-wide association study implicates immune dysfunction in the development of Hodgkin lymphoma. | |
dc.type | Journal Article | |
dcterms.dateAccepted | 2018-08-19 | |
rioxxterms.versionofrecord | 10.1182/blood-2018-06-855296 | |
rioxxterms.licenseref.uri | https://www.rioxx.net/licenses/under-embargo-all-rights-reserved | |
rioxxterms.licenseref.startdate | 2018-11 | |
rioxxterms.type | Journal Article/Review | |
dc.relation.isPartOf | Blood | |
pubs.issue | 19 | |
pubs.notes | Not known | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.organisational-group | /ICR | |
pubs.organisational-group | /ICR/Primary Group | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Breast Cancer Research/Complex Trait Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Aetiological Epidemiology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Cancer Genomics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Molecular Pathology/Molecular & Population Genetics | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging | |
pubs.organisational-group | /ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics | |
pubs.publication-status | Published | |
pubs.volume | 132 | |
pubs.embargo.terms | Not known | |
icr.researchteam | Complex Trait Genetics | |
icr.researchteam | Aetiological Epidemiology | |
icr.researchteam | Cancer Genomics | |
icr.researchteam | Molecular & Population Genetics | |
icr.researchteam | Oncogenetics | |
dc.contributor.icrauthor | Sud, Amit | |
dc.contributor.icrauthor | Orlando, Giulia | |
dc.contributor.icrauthor | Law, Philip | |
dc.contributor.icrauthor | Broderick, Peter | |
dc.contributor.icrauthor | Eeles, Rosalind | |
dc.contributor.icrauthor | Kote-Jarai, Zsofia | |
dc.contributor.icrauthor | Swerdlow, Anthony | |
dc.contributor.icrauthor | Houlston, Richard | |