Publications Repository

Publications Repository

View Item 
  •   Home
  • ICR Divisions
  • Other ICR Research
  • View Item
  • Home
  • ICR Divisions
  • Other ICR Research
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Measuring Clonal Evolution in Cancer with Genomics.

Thumbnail
View/Open
Accepted version (343.4Kb)
Publication Date
2019-08
ICR Author
Sottoriva, Andrea
Author
Williams, MJ
Sottoriva, A
Graham, TA
Type
Journal Article
Metadata
Show full item record
Abstract
Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal cell number. Viewed through the lens of evolutionary biology, the transformation of normal cells into malignant cells is evolution in action. Evolution continues throughout cancer growth, progression, treatment resistance, and disease relapse, driven by adaptation to changes in the cancer's environment, and intratumor heterogeneity is an inevitable consequence of this evolutionary process. Genomics provides a powerful means to characterize tumor evolution, enabling quantitative measurement of evolving clones across space and time. In this review, we discuss concepts and approaches to quantify and measure this evolutionary process in cancer using genomics.
URL
https://repository.icr.ac.uk/handle/internal/3494
Collections
  • Other ICR Research
Licenseref URL
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Version of record
10.1146/annurev-genom-083117-021712
Subject
Humans
Neoplasms
Sequence Analysis, DNA
Genomics
Mutation
Models, Genetic
High-Throughput Nucleotide Sequencing
Clonal Evolution
Language
eng
Date accepted
2019-05-06
License start date
2019-08
Citation
Annual review of genomics and human genetics, 2019, 20 pp. 309 - 329

Browse

All of ICR repositoryICR DivisionsIssue dateAuthorsTitlesSubjectsThis collectionIssue dateAuthorsTitlesSubjects

Statistics

Most popular itemsStatistics by countryMost popular authors
  • Login
  • Registered office: The Institute of Cancer Research, 123 Old Brompton Road, London, SW7 3RP
    A Charity, Not for Profit. Company Limited by Guarantee.
    Registered in England No. 534147. VAT Registration No. GB 849 0581 02.