Measuring Clonal Evolution in Cancer with Genomics.
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Date
2019-08-31Author
Williams, MJ
Sottoriva, A
Graham, TA
Type
Journal Article
Metadata
Show full item recordAbstract
Cancers originate from somatic cells in the human body that have accumulated genetic alterations. These mutations modify the phenotype of the cells, allowing them to escape the homeostatic regulation that maintains normal cell number. Viewed through the lens of evolutionary biology, the transformation of normal cells into malignant cells is evolution in action. Evolution continues throughout cancer growth, progression, treatment resistance, and disease relapse, driven by adaptation to changes in the cancer's environment, and intratumor heterogeneity is an inevitable consequence of this evolutionary process. Genomics provides a powerful means to characterize tumor evolution, enabling quantitative measurement of evolving clones across space and time. In this review, we discuss concepts and approaches to quantify and measure this evolutionary process in cancer using genomics.
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Subject
Humans
Neoplasms
Sequence Analysis, DNA
Genomics
Mutation
Models, Genetic
High-Throughput Nucleotide Sequencing
Clonal Evolution
Language
eng
Date accepted
2019-05-06
License start date
2019-08
Citation
Annual review of genomics and human genetics, 2019, 20 pp. 309 - 329
Publisher
ANNUAL REVIEWS