Functional versus non-functional intratumor heterogeneity in cancer.
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Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.
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Evolutionary Genomics & Modelling
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Molecular & cellular oncology, 2016, 3 (4), pp. e1162897 - ?