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Functional versus non-functional intratumor heterogeneity in cancer.

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Publication Date
2016-07
ICR Author
Sottoriva, Andrea
Author
Williams, MJ
Werner, B
Graham, TA
Sottoriva, A
Type
Journal Article
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Abstract
Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.
URL
https://repository.icr.ac.uk/handle/internal/443
Collections
  • Molecular Pathology
Version of record
10.1080/23723556.2016.1162897
Research team
Evolutionary Genomics & Modelling
Language
eng
Date accepted
2016-03-02
License start date
2016-07
Citation
Molecular & cellular oncology, 2016, 3 (4), pp. e1162897 - ?

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