Functional versus non-functional intratumor heterogeneity in cancer.
View/ Open
Date
2016-07ICR Author
Author
Williams, MJ
Werner, B
Graham, TA
Sottoriva, A
Type
Journal Article
Metadata
Show full item recordAbstract
Next-generation sequencing data from human cancers are often difficult to interpret within the context of tumor evolution. We developed a mathematical model describing the accumulation of mutations under neutral evolutionary dynamics and showed that 323/904 cancers (∼30%) from multiple types were consistent with the neutral model of tumor evolution.
Collections
Language
eng
Date accepted
2016-03-02
License start date
2016-07
Citation
Molecular & cellular oncology, 2016, 3 (4), pp. e1162897 - ?