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dc.contributor.authorMikropoulos, C
dc.contributor.authorSelkirk, CGH
dc.contributor.authorSaya, S
dc.contributor.authorBancroft, E
dc.contributor.authorVertosick, E
dc.contributor.authorDadaev, T
dc.contributor.authorBrendler, C
dc.contributor.authorPage, E
dc.contributor.authorDias, A
dc.contributor.authorEvans, DG
dc.contributor.authorRothwell, J
dc.contributor.authorMaehle, L
dc.contributor.authorAxcrona, K
dc.contributor.authorRichardson, K
dc.contributor.authorEccles, D
dc.contributor.authorJensen, T
dc.contributor.authorOsther, PJ
dc.contributor.authorvan Asperen, CJ
dc.contributor.authorVasen, H
dc.contributor.authorKiemeney, LA
dc.contributor.authorRingelberg, J
dc.contributor.authorCybulski, C
dc.contributor.authorWokolorczyk, D
dc.contributor.authorHart, R
dc.contributor.authorGlover, W
dc.contributor.authorLam, J
dc.contributor.authorTaylor, L
dc.contributor.authorSalinas, M
dc.contributor.authorFeliubadaló, L
dc.contributor.authorOldenburg, R
dc.contributor.authorCremers, R
dc.contributor.authorVerhaegh, G
dc.contributor.authorvan Zelst-Stams, WA
dc.contributor.authorOosterwijk, JC
dc.contributor.authorCook, J
dc.contributor.authorRosario, DJ
dc.contributor.authorBuys, SS
dc.contributor.authorConner, T
dc.contributor.authorDomchek, S
dc.contributor.authorPowers, J
dc.contributor.authorAusems, MG
dc.contributor.authorTeixeira, MR
dc.contributor.authorMaia, S
dc.contributor.authorIzatt, L
dc.contributor.authorSchmutzler, R
dc.contributor.authorRhiem, K
dc.contributor.authorFoulkes, WD
dc.contributor.authorBoshari, T
dc.contributor.authorDavidson, R
dc.contributor.authorRuijs, M
dc.contributor.authorHelderman-van den Enden, AT
dc.contributor.authorAndrews, L
dc.contributor.authorWalker, L
dc.contributor.authorSnape, K
dc.contributor.authorHenderson, A
dc.contributor.authorJobson, I
dc.contributor.authorLindeman, GJ
dc.contributor.authorLiljegren, A
dc.contributor.authorHarris, M
dc.contributor.authorAdank, MA
dc.contributor.authorKirk, J
dc.contributor.authorTaylor, A
dc.contributor.authorSusman, R
dc.contributor.authorChen-Shtoyerman, R
dc.contributor.authorPachter, N
dc.contributor.authorSpigelman, A
dc.contributor.authorSide, L
dc.contributor.authorZgajnar, J
dc.contributor.authorMora, J
dc.contributor.authorBrewer, C
dc.contributor.authorGadea, N
dc.contributor.authorBrady, AF
dc.contributor.authorGallagher, D
dc.contributor.authorvan Os, T
dc.contributor.authorDonaldson, A
dc.contributor.authorStefansdottir, V
dc.contributor.authorBarwell, J
dc.contributor.authorJames, PA
dc.contributor.authorMurphy, D
dc.contributor.authorFriedman, E
dc.contributor.authorNicolai, N
dc.contributor.authorGreenhalgh, L
dc.contributor.authorObeid, E
dc.contributor.authorMurthy, V
dc.contributor.authorCopakova, L
dc.contributor.authorMcGrath, J
dc.contributor.authorTeo, S-H
dc.contributor.authorStrom, S
dc.contributor.authorKast, K
dc.contributor.authorLeongamornlert, DA
dc.contributor.authorChamberlain, A
dc.contributor.authorPope, J
dc.contributor.authorNewlin, AC
dc.contributor.authorAaronson, N
dc.contributor.authorArdern-Jones, A
dc.contributor.authorBangma, C
dc.contributor.authorCastro, E
dc.contributor.authorDearnaley, D
dc.contributor.authorEyfjord, J
dc.contributor.authorFalconer, A
dc.contributor.authorFoster, CS
dc.contributor.authorGronberg, H
dc.contributor.authorHamdy, FC
dc.contributor.authorJohannsson, O
dc.contributor.authorKhoo, V
dc.contributor.authorLubinski, J
dc.contributor.authorGrindedal, EM
dc.contributor.authorMcKinley, J
dc.contributor.authorShackleton, K
dc.contributor.authorMitra, AV
dc.contributor.authorMoynihan, C
dc.contributor.authorRennert, G
dc.contributor.authorSuri, M
dc.contributor.authorTricker, K
dc.contributor.authorIMPACT study collaborators
dc.contributor.authorMoss, S
dc.contributor.authorKote-Jarai, Z
dc.contributor.authorVickers, A
dc.contributor.authorLilja, H
dc.contributor.authorHelfand, BT
dc.contributor.authorEeles, RA
dc.date.accessioned2018-01-11T14:28:43Z
dc.date.issued2018-01-04
dc.identifier.citationBritish journal of cancer, 2018, 118 (2), pp. 266 - 276
dc.identifier.issn0007-0920
dc.identifier.urihttps://repository.icr.ac.uk/handle/internal/993
dc.identifier.eissn1532-1827
dc.identifier.doi10.1038/bjc.2017.429
dc.description.abstractBACKGROUND:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. RESULTS:1634 participants had ⩾3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml-l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. CONCLUSIONS:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
dc.formatPrint-Electronic
dc.format.extent266 - 276
dc.languageeng
dc.language.isoeng
dc.rights.urihttps://creativecommons.org/licenses/by/4.0
dc.subjectIMPACT study collaborators
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectGenetic Predisposition to Disease
dc.subjectKallikreins
dc.subjectProstate-Specific Antigen
dc.subjectBRCA1 Protein
dc.subjectBRCA2 Protein
dc.subjectLogistic Models
dc.subjectGerm-Line Mutation
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectMale
dc.subjectEarly Detection of Cancer
dc.subjectNeoplasm Grading
dc.titleProstate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.
dc.typeJournal Article
dcterms.dateAccepted2017-11-06
rioxxterms.versionofrecord10.1038/bjc.2017.429
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-sa/4.0
rioxxterms.licenseref.startdate2018-01-04
rioxxterms.typeJournal Article/Review
dc.relation.isPartOfBritish journal of cancer
pubs.issue2
pubs.notesNot known
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.organisational-group/ICR
pubs.organisational-group/ICR/Primary Group
pubs.organisational-group/ICR/Primary Group/ICR Divisions
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Closed research teams/Clinical Academic Radiotherapy (Dearnaley)
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Genetics and Epidemiology/Oncogenetics
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging
pubs.organisational-group/ICR/Primary Group/ICR Divisions/Radiotherapy and Imaging/Oncogenetics
pubs.publication-statusPublished
pubs.volume118
pubs.embargo.termsNot known
icr.researchteamClinical Academic Radiotherapy (Dearnaley)en_US
icr.researchteamOncogeneticsen_US
dc.contributor.icrauthorKote-Jarai, Zsofiaen
dc.contributor.icrauthorEeles, Rosalinden
dc.contributor.icrauthorDearnaley, Daviden


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