Prostate-specific antigen velocity in a prospective prostate cancer screening study of men with genetic predisposition.

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Date
2018-01-04Author
Mikropoulos, C
Selkirk, CGH
Saya, S
Bancroft, E
Vertosick, E
Dadaev, T
Brendler, C
Page, E
Dias, A
Evans, DG
Rothwell, J
Maehle, L
Axcrona, K
Richardson, K
Eccles, D
Jensen, T
Osther, PJ
van Asperen, CJ
Vasen, H
Kiemeney, LA
Ringelberg, J
Cybulski, C
Wokolorczyk, D
Hart, R
Glover, W
Lam, J
Taylor, L
Salinas, M
Feliubadaló, L
Oldenburg, R
Cremers, R
Verhaegh, G
van Zelst-Stams, WA
Oosterwijk, JC
Cook, J
Rosario, DJ
Buys, SS
Conner, T
Domchek, S
Powers, J
Ausems, MG
Teixeira, MR
Maia, S
Izatt, L
Schmutzler, R
Rhiem, K
Foulkes, WD
Boshari, T
Davidson, R
Ruijs, M
Helderman-van den Enden, AT
Andrews, L
Walker, L
Snape, K
Henderson, A
Jobson, I
Lindeman, GJ
Liljegren, A
Harris, M
Adank, MA
Kirk, J
Taylor, A
Susman, R
Chen-Shtoyerman, R
Pachter, N
Spigelman, A
Side, L
Zgajnar, J
Mora, J
Brewer, C
Gadea, N
Brady, AF
Gallagher, D
van Os, T
Donaldson, A
Stefansdottir, V
Barwell, J
James, PA
Murphy, D
Friedman, E
Nicolai, N
Greenhalgh, L
Obeid, E
Murthy, V
Copakova, L
McGrath, J
Teo, S-H
Strom, S
Kast, K
Leongamornlert, DA
Chamberlain, A
Pope, J
Newlin, AC
Aaronson, N
Ardern-Jones, A
Bangma, C
Castro, E
Dearnaley, D
Eyfjord, J
Falconer, A
Foster, CS
Gronberg, H
Hamdy, FC
Johannsson, O
Khoo, V
Lubinski, J
Grindedal, EM
McKinley, J
Shackleton, K
Mitra, AV
Moynihan, C
Rennert, G
Suri, M
Tricker, K
IMPACT study collaborators
Moss, S
Kote-Jarai, Z
Vickers, A
Lilja, H
Helfand, BT
Eeles, RA
Type
Journal Article
Metadata
Show full item recordAbstract
BACKGROUND:Prostate-specific antigen (PSA) and PSA-velocity (PSAV) have been used to identify men at risk of prostate cancer (PrCa). The IMPACT study is evaluating PSA screening in men with a known genetic predisposition to PrCa due to BRCA1/2 mutations. This analysis evaluates the utility of PSA and PSAV for identifying PrCa and high-grade disease in this cohort. METHODS:PSAV was calculated using logistic regression to determine if PSA or PSAV predicted the result of prostate biopsy (PB) in men with elevated PSA values. Cox regression was used to determine whether PSA or PSAV predicted PSA elevation in men with low PSAs. Interaction terms were included in the models to determine whether BRCA status influenced the predictiveness of PSA or PSAV. RESULTS:1634 participants had ⩾3 PSA readings of whom 174 underwent PB and 45 PrCas diagnosed. In men with PSA >3.0 ng ml-l, PSAV was not significantly associated with presence of cancer or high-grade disease. PSAV did not add to PSA for predicting time to an elevated PSA. When comparing BRCA1/2 carriers to non-carriers, we found a significant interaction between BRCA status and last PSA before biopsy (P=0.031) and BRCA2 status and PSAV (P=0.024). However, PSAV was not predictive of biopsy outcome in BRCA2 carriers. CONCLUSIONS:PSA is more strongly predictive of PrCa in BRCA carriers than non-carriers. We did not find evidence that PSAV aids decision-making for BRCA carriers over absolute PSA value alone.
Subject
IMPACT study collaborators
Humans
Prostatic Neoplasms
Genetic Predisposition to Disease
Kallikreins
Prostate-Specific Antigen
BRCA1 Protein
BRCA2 Protein
Logistic Models
Germ-Line Mutation
Adult
Aged
Middle Aged
Male
Early Detection of Cancer
Neoplasm Grading
Research team
Clinical Academic Radiotherapy (Dearnaley)
Oncogenetics
Language
eng
Date accepted
2017-11-06
License start date
2018-01-04
Citation
British journal of cancer, 2018, 118 (2), pp. 266 - 276