Browsing Other ICR Research by author "Marsden,"
Now showing items 1-19 of 19
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An exploratory analysis of alkaline phosphatase, lactate dehydrogenase, and prostate-specific antigen dynamics in the phase 3 ALSYMPCA trial with radium-223.
Sartor, O; Coleman, RE; Nilsson, S; Heinrich, D; Helle, SI; et al. (2017-05)Background Baseline clinical variables are prognostic for overall survival (OS) in patients with castration-resistant prostate cancer (CRPC). Their prognostic and predictive value with agents targeting bone metastases, ... -
Bilateral mammoplasty for cancer: Surgical, oncological and patient-reported outcomes.
Di Micco, R; O'Connell, RL; Barry, PA; Roche, N; MacNeill, FA; et al. (2017-01)Introduction Bilateral mammoplasty (BM) can optimise oncological safety and aesthetic outcomes in women with large or ptotic breasts whose tumour to breast volume ratio or tumour location pose a challenge to standard ... -
Caelyx-induced unilateral erythrodysesthaesia secondary to venous thromboembolism.
Merika, EE; Gore, M; Fearfield, LA (2017-06) -
Clinical Development of PD-1/PD-L1 Immunotherapy for Gastrointestinal Cancers: Facts and Hopes.
Chau, I (2017-10)Gastrointestinal (GI) cancers are among the most deadly malignancies. Although serial incremental survival benefits have been made with cytotoxic chemotherapy with metastatic disease, a plateau of achievement has been ... -
Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study.
Ahmed, HU; El-Shater Bosaily, A; Brown, LC; Gabe, R; Kaplan, R; et al. (2017-02)Background Men with high serum prostate specific antigen usually undergo transrectal ultrasound-guided prostate biopsy (TRUS-biopsy). TRUS-biopsy can cause side-effects including bleeding, pain, and infection. Multi-parametric ... -
Diagnostic accuracy of the PROMIS study - Authors' reply.
Ahmed, HU; Brown, LC; Kaplan, R; Parker, C; Emberton, M (2017-07) -
Effect of radium-223 dichloride (Ra-223) on hospitalisation: An analysis from the phase 3 randomised Alpharadin in Symptomatic Prostate Cancer Patients (ALSYMPCA) trial.
Parker, C; Zhan, L; Cislo, P; Reuning-Scherer, J; Vogelzang, NJ; et al. (2017-01)Symptomatic skeletal events (SSEs) commonly occur in patients with bone metastases, often leading to hospitalisations and decreased quality-of-life. In the ALSYMPCA trial, radium-223 significantly improved overall survival ... -
Hematologic Safety of Radium-223 Dichloride: Baseline Prognostic Factors Associated With Myelosuppression in the ALSYMPCA Trial.
Vogelzang, NJ; Coleman, RE; Michalski, JM; Nilsson, S; O'Sullivan, JM; et al. (2017-02)Background Myelosuppression is common in patients with progressive castration-resistant prostate cancer and bone metastases. Radium-223 prolongs overall survival in these patients but may cause myelosuppression; understanding ... -
Low-risk Prostate Cancer: Identification, Management, and Outcomes.
Moschini, M; Carroll, PR; Eggener, SE; Epstein, JI; Graefen, M; et al. (2017-08)Context The incidence of low-risk prostate cancer (PCa) has increased as a consequence of prostate-specific antigen testing.Objective In this collaborative review article, we examine recent literature regarding low-risk ... -
ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer.
Crabb, SJ; Birtle, AJ; Martin, K; Downs, N; Ratcliffe, I; et al. (2017-10)Background Docetaxel and prednisolone chemotherapy (DP) extends survival in metastatic castration resistant prostate cancer (mCRPC). However, emergent clinical resistance is almost inevitable. AKT pathway activation is ... -
Ramucirumab as Second-Line Treatment in Patients With Advanced Hepatocellular Carcinoma: Analysis of REACH Trial Results by Child-Pugh Score.
Zhu, AX; Baron, AD; Malfertheiner, P; Kudo, M; Kawazoe, S; et al. (2017-02)Importance REACH is the first phase 3 trial to provide information on hepatocellular cancer (HCC) in the second-line (postsorafenib) setting categorized by Child-Pugh score, a scoring system used to measure the severity ... -
Salvage Treatment After Radical Prostatectomy.
Parker, C; Sydes, MR (2018-02) -
Sorafenib dose escalation in treatment-naïve patients with metastatic renal cell carcinoma: a non-randomised, open-label, Phase 2b study.
Gore, ME; Jones, RJ; Ravaud, A; Kuczyk, M; Demkow, T; et al. (2017-06)Objective To assess the efficacy and safety of sorafenib dose escalation in metastatic renal cell carcinoma (mRCC).Patients and methods Intra-patient dose escalation may enhance the clinical benefit of targeted anticancer ... -
Standard wide local excision or bilateral reduction mammoplasty in large-breasted women with small tumours: Surgical and patient-reported outcomes.
Di Micco, R; O'Connell, RL; Barry, PA; Roche, N; MacNeill, FA; et al. (2017-04)Introduction Oncoplastic breast surgery is used to extend the role of breast-conserving surgery (BCS) to women with an unfavourable tumour to breast volume ratio. However, large-breasted women with a relatively small breast ... -
The histology of ovarian cancer: worldwide distribution and implications for international survival comparisons (CONCORD-2).
Matz, M; Coleman, MP; Sant, M; Chirlaque, MD; Visser, O; et al. (2017-02)Objective Ovarian cancers comprise several histologically distinct tumour groups with widely different prognosis. We aimed to describe the worldwide distribution of ovarian cancer histology and to understand what role this ... -
The use of ultrasound in the clinical re-staging of the axilla after neoadjuvant chemotherapy (NACT).
Peppe, A; Wilson, R; Pope, R; Downey, K; Rusby, J (2017-10)Introduction Ultrasound (US) is the imaging modality of choice for staging the axilla prior to surgery in patients with breast cancer (BC). High pathological complete response rates in the axilla after NACT mean a more ... -
Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance.
Guy, DE; Vandersluis, A; Klotz, LH; Fleshner, N; Kiss, A; et al. (2018-06)BACKGROUND:Research examining the association between physical activity (PA) and prostate cancer (PCa) has accumulated; however, few studies have examined this association in the context of active surveillance. The current ... -
When no treatment is the best treatment: Active surveillance strategies for low risk prostate cancers.
Stavrinides, V; Parker, CC; Moore, CM (2017-07)Although the incidence of prostate cancer is rising due to PSA screening and increased life expectancy, the metastatic potential of low-grade, organ-confined disease remains low. An increasing number of studies suggest ...