Browsing Other ICR Research by title
Now showing items 586-605 of 1211
-
L-serine in disease and development
(PORTLAND PRESS LTD, 2003-05-01)The amino acid L-serine, one of the so-called non-essential amino acids, plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides ... -
The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes.
(FRONTIERS MEDIA SA, 2022-03-18)Dopamine (DA) is critically involved in different functions of the central nervous system (CNS) including control of voluntary movement, affect, reward, sleep, and cognition. One of the key components of DA neurotransmission ... -
Landscape of somatic mutations in 560 breast cancer whole-genome sequences.
(NATURE PUBLISHING GROUP, 2016-06-02)We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding ... -
Landscape of transcriptomic interactions between breast cancer and its microenvironment.
(NATURE PUBLISHING GROUP, 2019-07-15)Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour's microenvironment. Despite this complexity, ... -
Large Interobserver Variation in the International MR-LINAC Oropharyngeal Carcinoma Delineation Study
(ELSEVIER SCIENCE INC, 2017-10-01) -
Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.
(NATURE PORTFOLIO, 2023-04-26)Viruses mimic host short linear motifs (SLiMs) to hijack and deregulate cellular functions. Studies of motif-mediated interactions therefore provide insight into virus-host dependencies, and reveal targets for therapeutic ... -
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
(WILEY, 2023-07-11)Phosphorylation is a ubiquitous post-translation modification that regulates protein function by promoting, inhibiting or modulating protein-protein interactions. Hundreds of thousands of phosphosites have been identified ... -
Laser-free pelvic alignment in an online adaptive radiotherapy environment.
(2020-03)The MR-Linac (MRL) provides a novel treatment modality that enables online adaptive treatments, but also creates new challenges for patient positioning in a laser-free environment. The accuracy and duration of prostate ... -
Latest developments in local treatment: radiotherapy for early breast cancer.
(OXFORD UNIV PRESS, 2005-01-01) -
Leukemic transformation by the APL fusion protein PRKAR1A-RAR alpha critically depends on recruitment of RXR alpha
(AMER SOC HEMATOLOGY, 2010-01-21)PRKAR1A (R1A)-retinoic acid receptor-alpha (R1A-RAR alpha) is the sixth RAR alpha-containing fusion protein in acute promyelocytic leukemia (APL). Using the murine bone-marrow retroviral transduction/transformation assay, ... -
Local therapeutic approaches for the management of recurrent gynaecological cancer
(Institute of Cancer Research (University Of London), 2022-02-28)Surgery, radiotherapy and chemotherapy combinations are used to treat recurrent gynaecological malignancy. Stereotactic body radiotherapy (SBRT) delivered to the involved surgical margin could improve clinical outcomes ... -
Long-range effects of retroviral insertion on c-myb: Overexpression may be obscured by silencing during tumor growth in vitro
(AMER SOC MICROBIOLOGY, 2003-01)The c-myb oncogene is a frequent target for retroviral activation in hemopoietic tumors of avian and mammalian species. While insertions can target the gene directly, numerous clusters of retroviral insertion sites have ... -
Long-term multicentre experience of adjuvant radiotherapy for pN3 squamous cell carcinoma of the penis.
(2020-11-29)Objective To present the long-term adjuvant radiotherapy outcomes of patients with pN3 squamous cell carcinoma of the penis (SCCp) treated at two UK centres.Patients and methods We conducted a retrospective audit of all ... -
Long-Term Response to Sunitinib Treatment in Metastatic Renal Cell Carcinoma: A Pooled Analysis of Clinical Trials.
(2017-06-20)Background We characterized clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) treated with sunitinib who were long-term responders (LTRs), defined as patients having progression-free survival (PFS) ... -
Long-term survival of patients with CLL after allogeneic transplantation: a report from the European Society for Blood and Marrow Transplantation
(Springer Science and Business Media LLC, 2017-03) -
"The Longest Way Round Is The Shortest Way Home": An Overhaul of Surgical Ward Rounds.
(SPRINGER, 2018-04-01)BACKGROUND: Ward rounds, a keystone of hospital surgical practice, have recently been under the spotlight. Poor-quality ward rounds can lead to a greater number of adverse events, thereby cascading to an increased financial ... -
Longitudinal cohort analysis of patients with metastatic penile cancer treated in a large quaternary academic centre
(SAGE PUBLICATIONS LTD, 2021-06-22) -
Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.
(PUBLIC LIBRARY SCIENCE, 2019-09-01)Bardet-Biedl syndrome (BBS), a ciliopathy, is a rare genetic condition characterised by retinal degeneration, obesity, kidney failure, and cognitive impairment. In spite of progress made in our general understanding of BBS ...
