Browsing Other ICR Research by title
Now showing items 572-591 of 1002
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National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection - recommendations from a UK consensus meeting.
(2018-07)OBJECTIVES:To identify areas of agreement and disagreement in the implementation of multi-parametric magnetic resonance imaging (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS:Fifteen UK experts ... -
National survey of fiducial marker insertion for prostate image guided radiotherapy.
Introduction In the United Kingdom fiducial marker IGRT is the second most common verification method employed in radical prostate radiotherapy yet little evidence exists to support centres introducing or developing this ... -
Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks
(2017-02)Evolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in ... -
Negative and positive regulation of HIF-1: A complex network
(ELSEVIER SCIENCE BV, 2005-07-25)Hypoxia inducible factor-1 (HIF-1) is as a key transcriptional mediator of the hypoxic response in eukaryotic cells, regulating the expression of a myriad of genes involved in oxygen transport, glucose uptake and glycolysis ... -
Network medicine
(Wiley-Blackwell, 2008-02-20)To more effectively target complex diseases like cancer, diabetes and schizophrenia, we may need to rethink our strategies for drug development and the selection of molecular targets for pharmacological treatments. Here, ... -
Network-based drugs and biomarkers.
(2010-01)The structure and dynamics of protein signalling networks governs cell decision processes and the formation of tissue boundaries. Complex diseases such as cancer and diabetes are diseases of such networks. Therefore ... -
NetworKIN: a resource for exploring cellular phosphorylation networks
(OXFORD UNIV PRESS, 2008-01)Protein kinases control cellular responses by phosphorylating specific substrates. Recent proteome-wide mapping of protein phosphorylation sites by mass spectrometry has discovered thousands of in vivo sites. Systematically ... -
Neuroblastoma in monozygotic twins - a case of probable twin to twin metastasis (vol 85, pg 493, 2001)
(NATURE PUBLISHING GROUP, 2002-05-20) -
Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project.
(2017-02)Background The incidence of second malignant neoplasm (SMN) within the first ten years of diagnosis in high-risk neuroblastoma patients treated with modern, intensive therapy is unknown. Further, the underlying germline ... -
New insights into the families of PLC enzymes: looking back and going forward
(Portland Press Limited, 2005)A study in this issue of the Biochemical Journal by Harden and colleagues, in association with one published in the Biochemical Journal very recently [Hwang, Oh, Shin, Kim, Ryu and Suh (2005) Biochem. J. 389, 181–186], ... -
New method for the preparation of 3 ‘- and 2 ‘-O-phosphoramidites of 2 ‘- and 3 ‘-difluoromethyluridine derivatives
(2002)Hydrogenation of 2-deoxy-2’-difluoromethylene-5’-O-dimethoxytrityluridine (1) and 3’-deoxy-3’-difluoromethylene-5’-O-dimethoxytrityluridine (7), gave the corresponding 2- and 3’-difluoromethyluridine derivatives 2a and 8a. ... -
New Model for Estimating Glomerular Filtration Rate in Patients With Cancer
(American Society of Clinical Oncology (ASCO), 2017-08-20)<jats:sec><jats:title>Purpose</jats:title><jats:p> The glomerular filtration rate (GFR) is essential for carboplatin chemotherapy dosing; however, the best method to estimate GFR in patients with cancer is unknown. We ... -
Nipple sparing versus skin sparing mastectomy: a systematic review protocol.
(2016-05-20)Introduction Breast cancer has a lifetime incidence of one in eight women. Over the past three decades there has been a move towards breast conservation and a focus on aesthetic outcomes while maintaining oncological safety. ... -
Nipple-sparing mastectomy in women at high risk of developing breast cancer.
(2018-06)Nipple-sparing mastectomy is a valuable addition to the options available for women at high risk of developing breast cancer. In this review, we summarize current knowledge about the high-risk genes, <i>BRCA1</i>, <i>BRCA2</i> ... -
Nivolumab Plus Ipilimumab for Treatment-Naïve Metastatic Uveal Melanoma: An Open-Label, Multicenter, Phase II Trial by the Spanish Multidisciplinary Melanoma Group (GEM-1402).
(2021-01-08)Purpose This study aimed to assess the efficacy of the combination of nivolumab (nivo) plus ipilimumab (ipi) as a first-line therapy with respect to the 12-month overall survival (OS) in patients with metastatic uveal ... -
Non-Mono-Exponential Analysis of Diffusion-Weighted Imaging for Treatment Monitoring in Prostate Cancer Bone Metastases.
(2017-07-19)Diffusion-weighted imaging quantified using the mono-exponential model has shown great promise for monitoring treatment response in prostate cancer bone metastases. The aim of this prospective study is to evaluate whether ... -
Novel approaches to polynuclear platinum pro-drugs. Selective release of cytotoxic platinum spermidine species through hydrolytic cleavage of carbamates
(AMER CHEMICAL SOC, 2001-11-19)BBR3464 is a novel trinuclear platinum drug currently in Phase II clinical trials. Polyamine-bridged dinuclear platinum compounds as represented by [trans-Pt(NH3)(2)Cl(2)-mu -spermidine-N-1,N-8]Cl-3 (1) are highly interesting ... -
Novel photoacid generators for photodirected oligonucleotide synthesis
(2003-01-29)Photodirected oligonucleotide synthesis uses either direct or indirect light-dependent 5’deprotection. Both have been reported to give lower stepwise synthetic yields than conventional methods. The deficiency appears to ... -
Nuclear envelope assembly is promoted by phosphoinositide-specific phospholipase C with selective recruitment of phosphatidylinositol-enriched membranes
(PORTLAND PRESS LTD, 2005-04-15)Nuclear envelope (NE) formation in a cell-free egg extract proceeds by precursor membrane vesicle binding to chromatin in an ATP-dependent manner, followed by a GTP-induced NE assembly step. The requirement for GTP in the ... -
Nuclear export of α-catenin: overlap between nuclear export signal sequences and the β-catenin binding site
(2004)Mutations in APC or in β-catenin, which are common in colon cancer, lead to constitutive activation of β-catenin/Tcf-dependent signaling. α-Catenin is also found in some colon cancer cell nuclei, and loss of its expression ...
